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  3. Ferric citrate

Ferric citrate (Synonyms: Iron(III) citrate; Zerenex)

Cat. No.: HY-N1428C Purity: ≥98.0%
Handling Instructions

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.

For research use only. We do not sell to patients.

Ferric citrate Chemical Structure

Ferric citrate Chemical Structure

CAS No. : 3522-50-7

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.

In Vitro

Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death[1].
Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Cardiomyocyte (CM) cells
Concentration: 1 mM
Incubation Time: 24 hours
Result: Significantly induced CM cell death.
In Vivo

Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival[3].
Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can increase transferrin saturation, serum ferritin, and hemoglobin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.94

Formula

C₆H₅FeO₇

CAS No.
SMILES

O=C(CC(C([O-])=O)(O)CC([O-])=O)[O-].[Fe+3]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (20.41 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0826 mL 20.4132 mL 40.8263 mL
5 mM 0.8165 mL 4.0826 mL 8.1653 mL
10 mM 0.4083 mL 2.0413 mL 4.0826 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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Keywords:

FerricIron(III) ZerenexReactive Oxygen SpecieshyperphosphatemiaironsupplementphosphatebinderFGF23 chronickidneydiseaseInhibitorinhibitorinhibit

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Ferric citrate
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HY-N1428C
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