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Art. -Nr.: HY-P2149A

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Concanavalin A (agarose)

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Concanavalin A (agarose) is composed of Concanavalin A (HY-P2149) conjugated with agarose. Concanavalin A (ConA) is a selective competitive binder targeting the specific carbohydrate structures of glucose and mannose, inducing mitosis, and exhibiting certain cytotoxicity, hepatotoxicity, and teratogenicity. Concanav in A (agarose) can be used for in vivo blood glucose monitoring in diabetes, and for "fishing out" specific glycoproteins or removing sugar impurities from complex samples.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 11028-71-0

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Concanavalin A (agarose) Chemical Structure

CAS. Nr.: 11028-71-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Concanavalin A (agarose) is primarily used for protein purification from complex samples, such as cytokines, membrane proteins, and serum glycoproteins; or for removing unwanted glycoprotein impurities from samples; or for studying the interaction strength between glycoproteins and ConA (e.g., under different elution conditions)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mouse spleen cells, human B lymphocytes, human T lymphocytes, murine T lymphocytes
Concentration:

3-6 μg/mL (optimal), 10 μg/mL, 25 μg/mL
Incubation Time:

72 h
Result:

Concanavalin A (agarose) directly stimulated B cells and T cells to synthesize DNA and proliferate, with the optimal concentration ranging from 3 to 6 μg/mL. The dose-response curve declined sharply when the concentration exceeded 10 μg/mL. It induced the production of interferon in spleen cells from C57BL/6 mice at 25 μg/mL. The mitogenic effect on lymphocytes was age-dependent, with impaired responses observed in lymphocytes from older individuals and murine T lymphocyte subsets.

In Vivo

Animal Model:

Rabbits (body weight 2 kg, 2.9 kg, 3.1 kg, 1.3 kg)^[1]
Dosage:

Rabbits: 1 mg, 2.4 mg, 4 mg, 7 mg, 15 mg
Administration:

intravenous injection
Result:

Caused no symptoms in rabbits.
Administration of 7 mg ConA to a 1.3 kg rabbit resulted in death within 2 days, while 15 mg ConA injected into a 2 kg rabbit induced intravascular erythrocyte agglutination and the rabbit was euthanized.

Chemical Information

CAS. Nr. 11028-71-0
Appearance Liquid (Density: 1.434±0.06 g/cm³)
Color Colorless to light yellow
SMILES

[Concanavalin A (agarose)]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ballerstadt R, et al. Concanavalin A for in vivo glucose sensing: a biotoxicity review. Biosens Bioelectron. 2006 Aug 15;22(2):275-84. [Content Brief]

[2]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6. [Content Brief]

[3]. Cantelli A, et al. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852. [Content Brief]

[4]. Zhou Y, et al. The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice. Gastroenterol Res Pract. 2015;2015:506390. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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