2. Apoptosis
  3. Apoptosis
  4. XL44

XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins.

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XL44 Chemical Structure

XL44 Chemical Structure

CAS No. : 2637949-91-6

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XL44 Related Antibodies

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Description

XL44, an hRpn13 binder, induces hRpn13-dependent apoptosis and also restricts cell viability by a PCLAF-dependent mechanism. XL44 induces ubiquitin-dependent loss of hRpn13Pru and ubiquitin-independent loss of select KEN box containing proteins[1].

In Vitro

XL44 (20 μM, 4-24 h, lysates from RPMI 8226 cells) induces apoptosis in an hRpn13-dependent manner and reduces hRpn13Pru levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XL44 Related Antibodies

Western Blot Analysis[1].

Cell Line: Lysates from RPMI 8226 cells.
Concentration: 20 μM.
Incubation Time: 4-24 h.
Result: Caused a reduction in hRpn13Pru levels in RPMI 8226 WT cells.
Molecular Weight

388.39

Formula

C23H17FN2O3
CAS No.
SMILES

O=C(C1=CC=C(OC)C=C1)NC2=CC=CC(/C=C3C(NC4=C\3C=C(F)C=C4)=O)=C2
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Purity & Documentation
References
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XL44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XL442637949-91-6XL 44XL-44ApoptosishRpn13PruKENapoptosisInhibitorinhibitorinhibit

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