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Cat. No.: HY-156746

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DBt-10

DBt-10 is a potent BTK PROTAC degrader (DC₅₀: 137 nM). Blue: DCAF1 binder (HY-149934); Black: linker; Pink: BTK ligand.
(Pink: Target protein ligand; Blue: Cereblon ligand (HY-149934); Black: linker).

For research use only. We do not sell to patients.

Formula: C₆₈H₈₆ClFN₁₆O₆
Molecular Weight:1277.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

DBt-10 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DBt-10 is a potent BTK PROTAC degrader (DC₅₀: 137 nM). Blue: DCAF1 binder (HY-149934); Black: linker; Pink: BTK ligand^[1]. (Pink: Target protein ligand; Blue: Cereblon ligand (HY-149934); Black: linker).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 1277.97
Formula C₆₈H₈₆ClFN₁₆O₆
SMILES

ClC(C=C1)=CC=C1C2(CCCCC2)C3=NC4=CC(N5CCN(C(CCCC(NCCN6CC7(CCN(C(CN8C=C(C9=CC(C(C%10=C(C)C(NC(N%11CC(CC(C)(C)C)(O)C%11)=O)=CC(F)=C%10)=NC=N%12)=C%12N9)C=N8)=O)CC7)OCC6)=O)=O)CC5)=CC=C4C(NCCN)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Martin Schröder, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15(1):275. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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