E3 ligase Ligand 23
Based on 1 Customer Validation
E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway.
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- Pureté : 98.39%
- CAS No.: 444287-56-3
- Formule: C20H17N3O4
- Masse moléculaire:363.37
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Cereblon |
Chemical Information
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CAS No. 444287-56-3
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Appearance Solid
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Masse moléculaire 363.37
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Formule C20H17N3O4
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Color Yellow to green
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC4=CC=CC=C4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (275.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7520 mL | 13.7601 mL | 27.5202 mL | 68.8004 mL |
| 5 mM | 0.5504 mL | 2.7520 mL | 5.5040 mL | 13.7601 mL | |
| 10 mM | 0.2752 mL | 1.3760 mL | 2.7520 mL | 6.8800 mL | |
| 15 mM | 0.1835 mL | 0.9173 mL | 1.8347 mL | 4.5867 mL | |
| 20 mM | 0.1376 mL | 0.6880 mL | 1.3760 mL | 3.4400 mL | |
| 25 mM | 0.1101 mL | 0.5504 mL | 1.1008 mL | 2.7520 mL | |
| 30 mM | 0.0917 mL | 0.4587 mL | 0.9173 mL | 2.2933 mL | |
| 40 mM | 0.0688 mL | 0.3440 mL | 0.6880 mL | 1.7200 mL | |
| 50 mM | 0.0550 mL | 0.2752 mL | 0.5504 mL | 1.3760 mL | |
| 60 mM | 0.0459 mL | 0.2293 mL | 0.4587 mL | 1.1467 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8600 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2752 mL | 0.6880 mL |
E3 ligase Ligand 23 Related Classifications
HY-144985 Related Classifications
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