Manninotriose
Based on 1 publication(s) in Google Scholar
Manninotriose is a natural functional trisaccharide composed of three mannose molecules. Manninotriose binds to dihydrofolate reductase via hydrogen bond formation with Arg28. Manninotriose binds to thymidylate synthase via hydrogen bond formation with Arg50. Manninotriose acts as a membrane protectant and helps improve stress tolerance. Manninotriose can be used in research related to acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 13382-86-0
- Formula: C18H32O16
- Molecular Weight:504.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Manninotriose
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Biological Activity
Manninotriose binds to human DHFR with a docking score of 129.7870 via a hydrogen bond interaction with the Arg28 residue[1].
Manninotriose binds to human TS with a docking score of 114.6030 via a hydrogen bond interaction with the Arg50 residue[1].
Manninotriose is degraded by α-galactosidase but is insensitive to invertase treatment[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13382-86-0
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Appearance Solid
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Molecular Weight 504.44
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Formula C18H32O16
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Color White to off-white
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SMILES
O[C@@H]([C@@H](O)[C@H](O)[C@@H](O)C=O)CO[C@H]([C@@H]([C@@H](O)[C@H]1O)O)O[C@@H]1CO[C@H]([C@@H]([C@@H](O)[C@H]2O)O)O[C@@H]2CO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Chromatogr B Analyt Technol Biomed Life Sci
Distinguishing native trisaccharides having differential monosaccharide composition and linkage using PGC-LC MS/MS. [Abstract]2025 Nov 15:1269:124849. PMID: 41270636
Solvent & Solubility
H2O : 125 mg/mL (247.80 mM; Need ultrasonic)
DMSO : 100 mg/mL (198.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (198.24 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
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- Español - ES (393 KB)
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- Italian - IT (393 KB)
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- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Hsiao YL, et al. Treatment of acute lymphoblastic leukemia from traditional chinese medicine. Evid Based Complement Alternat Med. 2014;2014:601064. [Content Brief]
[2]. dos Santos R, et al. Manninotriose is a major carbohydrate in red deadnettle (Lamium purpureum, Lamiaceae). Ann Bot. 2013;111(3):385-393. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.9824 mL | 9.9120 mL | 19.8240 mL | 49.5599 mL |
| 5 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL | 9.9120 mL | |
| 10 mM | 0.1982 mL | 0.9912 mL | 1.9824 mL | 4.9560 mL | |
| 15 mM | 0.1322 mL | 0.6608 mL | 1.3216 mL | 3.3040 mL | |
| 20 mM | 0.0991 mL | 0.4956 mL | 0.9912 mL | 2.4780 mL | |
| 25 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9824 mL | |
| 30 mM | 0.0661 mL | 0.3304 mL | 0.6608 mL | 1.6520 mL | |
| 40 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2390 mL | |
| 50 mM | 0.0396 mL | 0.1982 mL | 0.3965 mL | 0.9912 mL | |
| 60 mM | 0.0330 mL | 0.1652 mL | 0.3304 mL | 0.8260 mL | |
| 80 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6195 mL | |
| 100 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.4956 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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