2. Immunology/Inflammation
  3. LAG-3
  4. Z3071585108

Z3071585108 is a small molecule binder of the LAG-3 D1 domain with Kd values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3.

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Z3071585108

Z3071585108 Chemical Structure

CAS No. : 2249005-28-3

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Description

Z3071585108 is a small molecule binder of the LAG-3 D1 domain with Kd values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3[1].

Molecular Weight

304.35

Formula

C17H16N6
CAS No.
SMILES

N#CC(C=CN=N1)=C1N(C2)CCCC2C3=CNC4=NC=CC=C43
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Z3071585108 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z30715851082249005-28-3Z 3071585108Z-3071585108LAG-3Lymphocyte activation gene-3CD223immune checkpointcryptic pocketmolecular dynamicsvirtual screeningmicroscale thermophoresisHTRFsmall-molecule inhibitorInhibitorinhibitorinhibit

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