DBr-1
Based on 1 Customer Validation
DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352).
(Pink: BRD9 ligand (HY-100352); Blue: Cereblon ligand (HY-149934); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.87%
- Formula: C55H68ClN9O5
- Molecular Weight:970.64
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All PROTACs Isoforms
More
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 970.64
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Formula C55H68ClN9O5
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Color Off-white to light yellow
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SMILES
COC1=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C(OC)C(CN4CCC(OCCCCCC(N5CCN(C6=CC=C7C(N=C(C8(C9=CC=C(Cl)C=C9)CCCCC8)N=C7NCCN)=C6)CC5)=O)CC4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (103.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0302 mL | 5.1512 mL | 10.3025 mL | 25.7562 mL |
| 5 mM | 0.2060 mL | 1.0302 mL | 2.0605 mL | 5.1512 mL | |
| 10 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5756 mL | |
| 15 mM | 0.0687 mL | 0.3434 mL | 0.6868 mL | 1.7171 mL | |
| 20 mM | 0.0515 mL | 0.2576 mL | 0.5151 mL | 1.2878 mL | |
| 25 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0302 mL | |
| 30 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8585 mL | |
| 40 mM | 0.0258 mL | 0.1288 mL | 0.2576 mL | 0.6439 mL | |
| 50 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5151 mL | |
| 60 mM | 0.0172 mL | 0.0859 mL | 0.1717 mL | 0.4293 mL | |
| 80 mM | 0.0129 mL | 0.0644 mL | 0.1288 mL | 0.3220 mL | |
| 100 mM | 0.0103 mL | 0.0515 mL | 0.1030 mL | 0.2576 mL |
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