country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P11655

Copy Link Print Information

NOTA-TATE

Customer Review

Based on 1 Customer Validation

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours.

For research use only. We do not sell to patients.

Purity: 95.38%
CAS No.: 709043-21-0
Formula: C₆₁H₈₃N₁₃O₁₇S₂
Molecular Weight:1334.52

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

NOTA-TATE Chemical Structure

CAS No.: 709043-21-0

Size

Price

Stock

Quantity

Amount: USD 0.00

or

or

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours^[1].

All Somatostatin Receptor Isoforms :

In Vivo

⁶⁸Ga-NOTA-TATE (0.1 mCi/2.96 MBq; i.v.; single dose) demonstrates comparable tumour uptake to ⁶⁸Ga-DOTA-TATE in AR42J tumour-bearing nude mice within 1 h post-injection, with clear tumour visualization on micro-PET/CT^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (15-20 g; 2 females and 2 males per group for 15 min, 30 min, 1 h, 2 h time points; 3 females and 3 males for imaging; AR42J pancreatic tumour xenografts)^[1]
Dosage:

0.1 mCi (8.8 GBq/mg) (biodistribution); 2.96 MBq (0.08 mCi) (imaging)
Administration:

i.v.; single dose
Result:

Reached tumour uptake of 3.24 ± 1.03 %ID/g at 15 min, 3.97 ± 2.24 %ID/g at 30 min, 3.16 ± 1.92 %ID/g at 1 h, and 1.33 ± 0.96 %ID/g at 2 h post-injection; Showed clear tumour visualization on micro-PET/CT images at 30 min and 2 h post-injection; Displayed intense radioactivity in gallbladder on imaging.

Chemical Information

CAS No. 709043-21-0
Appearance Solid
Molecular Weight 1334.52
Formula C₆₁H₈₃N₁₃O₁₇S₂
Color White to off-white
Sequence

{dPhe-NOTA}-Cys-Tyr-dTrp-Lys-Thr-Cys-Thr (disulfide bridge:Cys2-Cys7)
Sequence Shortening

{dPhe-NOTA}-CY-dTrp-KTCT (disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. HY-P11655.pdf [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=

Concentration Concentration

×

Volume Volume

×

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References