NOTA-TATE
NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours.
For research use only. We do not sell to patients.
- CAS No.: 709043-21-0
- Formula: C61H83N13O17S2
- Molecular Weight:1334.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (15-20 g; 2 females and 2 males per group for 15 min, 30 min, 1 h, 2 h time points; 3 females and 3 males for imaging; AR42J pancreatic tumour xenografts)[1]
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Dosage:0.1 mCi (8.8 GBq/mg) (biodistribution); 2.96 MBq (0.08 mCi) (imaging)
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Administration:i.v.; single dose
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Result:Reached tumour uptake of 3.24 ± 1.03 %ID/g at 15 min, 3.97 ± 2.24 %ID/g at 30 min, 3.16 ± 1.92 %ID/g at 1 h, and 1.33 ± 0.96 %ID/g at 2 h post-injection; Showed clear tumour visualization on micro-PET/CT images at 30 min and 2 h post-injection; Displayed intense radioactivity in gallbladder on imaging.
Chemical Information
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CAS No. 709043-21-0
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Molecular Weight 1334.52
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Formula C61H83N13O17S2
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Sequence
{dPhe-NOTA}-Cys-Tyr-dTrp-Lys-Thr-Cys-Thr (disulfide bridge:Cys2-Cys7)
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Sequence Shortening
{dPhe-NOTA}-CY-dTrp-KTCT (disulfide bridge:Cys2-Cys7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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