2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. NOTA-TATE

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NOTA-TATE

NOTA-TATE Chemical Structure

CAS No. : 709043-21-0

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NOTA-TATE Related Antibodies

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Description

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours[1].

In Vivo

68Ga-NOTA-TATE (0.1 mCi/2.96 MBq; i.v.; single dose) demonstrates comparable tumour uptake to 68Ga-DOTA-TATE in AR42J tumour-bearing nude mice within 1 h post-injection, with clear tumour visualization on micro-PET/CT[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (15-20 g; 2 females and 2 males per group for 15 min, 30 min, 1 h, 2 h time points; 3 females and 3 males for imaging; AR42J pancreatic tumour xenografts)[1]
Dosage: 0.1 mCi (8.8 GBq/mg) (biodistribution); 2.96 MBq (0.08 mCi) (imaging)
Administration: i.v.; single dose
Result: Reached tumour uptake of 3.24 ± 1.03 %ID/g at 15 min, 3.97 ± 2.24 %ID/g at 30 min, 3.16 ± 1.92 %ID/g at 1 h, and 1.33 ± 0.96 %ID/g at 2 h post-injection; Showed clear tumour visualization on micro-PET/CT images at 30 min and 2 h post-injection; Displayed intense radioactivity in gallbladder on imaging.
Molecular Weight

1334.52

Formula

C61H83N13O17S2
CAS No.
Sequence

{dPhe-NOTA}-Cys-Tyr-dTrp-Lys-Thr-Cys-Thr (disulfide bridge:Cys2-Cys7)
Sequence Shortening

{dPhe-NOTA}-CY-dTrp-KTCT (disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOTA-TATE Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-TATE709043-21-0Somatostatin ReceptorSSTRsSSTRhuman serumSSTR2-positive tumour cellsSSTR2human plasmaKunming micePET imaging agentsomatostatin receptor 2AR42J tumour-bearing nude miceneuroendocrine tumoursInhibitorinhibitorinhibit

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