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Cat. No.: HY-152242

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YEATS4-IN-1

(Synonyms: PFI-8)

YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a K_i value of 33 nM.

For research use only. We do not sell to patients.

CAS No.: 3034365-92-6
Formula: C₂₄H₃₆N₄O₂
Molecular Weight:412.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

YEATS4-IN-1 Chemical Structure

CAS No.: 3034365-92-6

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a K_i value of 33 nM^[1].

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	IC₅₀	>50 μM Compound: 4d	Cytotoxicity against human Bone marrow cell assessed as reduction in cell viability measured after 7 days Cytotoxicity against human Bone marrow cell assessed as reduction in cell viability measured after 7 days	[PMID: 36562986]

In Vivo

The pharmacokinetic parameters of NAMPT degrader-3(4d)(p.o., 100 mg/kg) in mice

4d	T_1/2 (h)	AUC(ng*min/mL)	T_max (h)	C_mas (ng/mL)
	1.2	24700	0.5	9140

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034365-92-6
Molecular Weight 412.57
Formula C₂₄H₃₆N₄O₂
SMILES

OC1(CN2C[C@H](C)[C@@H](C3=C(C=CC(C(NCC)=O)=C4)N4N=C3C)CC2)CCCCC1
Synonyms

PFI-8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Allyn T Londregan, et al. Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J Med Chem. 2023 Jan 12;66(1):460-472. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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