PSMA-1-DOTA
PSMA-1-DOTA is a prostate-specific membrane antigen (PSMA) binder with high affinity, enables targeted radionuclide delivery for imaging and therapy. PSMA-1-DOTA acts as a tumor growth inhibitor that reduces growth of PSMA-expressing prostate cancer tumors.
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- CAS No.: 3024672-17-8
- 화학식: C62H100N14O27
- 분자량:1473.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
[177Lu]Lu-PSMA-1-DOTA (111 MBq total, 4 doses of 27.75 MBq over 2 days; 111 MBq single dose; i.v.) effectively inhibits tumor growth in PC3pip xenograft mice for 24 days[1].
[68Ga]Ga-PSMA-1-DOTA (7.4 MBq; i.v.) targets PC3pip tumors with minimal non-target uptake in kidneys and salivary glands in xenograft mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:athymic nude [Foxn1/nu/Foxn1/nu] (male, 6-8 weeks old, PC3pip subcutaneous xenograft model)[1]
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Dosage:111 MBq (3 mCi) total, 4 doses of 27.75 MBq each over 2 days; 111 MBq (3 mCi) single dose
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Administration:i.v.; 4 doses over 2 days (day 0); single dose (day 13)
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Result:Eliminated tumor growth for 24 days; achieved tumor inhibitory activity comparable to [¹⁷⁷Lu]Lu-PSMA-617 (positive control).
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Animal Model:athymic nude [Foxn1/nu/Foxn1/nu] (male, PC3pip subcutaneous xenograft model)[1]
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Dosage:7.4 MBq (200 μCi)
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Administration:i.v.
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Result:Showed significantly lower kidney and salivary gland uptake compared to [⁶⁸Ga]Ga-PSMA-11 and [⁶⁸Ga]Ga-PSMA I&T; reached tumor-to-left salivary gland ratio of 13.45 at 30 minutes and 27.43 at 1 hour post-injection.
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Animal Model:NMRI (male, 8 weeks old)[1]
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Dosage:1.4 mg/kg
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Administration:i.v.; single dose
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Result:Observed no mortality, significant body weight changes, or abnormal clinical signs; detected no significant changes in clinical chemistry parameters on day 2 or day 15; identified test item-related histopathological changes in spleen, bone marrow, and inguinal lymph nodes (present after 14-day recovery).
Chemical Information
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CAS No. 3024672-17-8
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분자량 1473.54
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화학식 C62H100N14O27
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SMILES
OC(CN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CCN1CC(NCCCC[C@@H](C(N)=O)NC([C@@H](CCC(O)=O)NC([C@@H](CCC(O)=O)NC([C@@H](CCC(O)=O)NC(CCCCCNC(C2CCC(CC2)CNC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA-1-DOTA Related Classifications
HY-185167 Related Classifications
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