cysteines

By Targets:	ADC Linker (4) Adrenergic Receptor (1) Amino Acid Derivatives (59) Amyloid-β (1) Antibiotic (3) Apoptosis (13) Aryl Hydrocarbon Receptor (1) ASCT (4) Atg4 (2) Autophagy (7) Bacterial (9) Beta-lactamase (2) Biochemical Assay Reagents (4) Btk (1) c-Myc (1) Calcium Channel (1) Cannabinoid Receptor (1) Caspase (2) Cathepsin (25) CCR (1) CDK (1) CXCR (1) Cytochrome P450 (2) Deubiquitinase (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (3) Dopamine Transporter (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (2) EAAT (2) EGFR (2) Elastase (1) Endogenous Metabolite (33) Epigenetic Reader Domain (2) Ferroptosis (4) Filovirus (1) Fluorescent Dye (18) Fungal (2) Glycosyltransferase (1) Glyoxalase (GLO) (1) HCV Protease (1) HDAC (1) Hedgehog (1) Hippo (MST) (1) Histamine Receptor (1) Histone Acetyltransferase (1) Histone Methyltransferase (1) HIV (1) HSV (2) ICMT (2) IFNAR (1) iGluR (3) IKK (1) Influenza Virus (5) Integrin (2) Interleukin Related (1) Isotope-Labeled Compounds (38) JAK (2) Keap1-Nrf2 (3) Kinesin (1) Legumain (1) mAChR (1) MDM-2/p53 (3) Microtubule/Tubulin (1) Mitophagy (1) Molecular Glues (1) Mps1 (1) NF-κB (4) NO Synthase (1) Opioid Receptor (1) Oxytocin Receptor (1) Parasite (7) Phosphodiesterase (PDE) (1) PKA (1) PKC (1) PROTAC Linkers (1) Proteasome (4) RAD51 (1) Ras (2) Reactive Oxygen Species (9) RGS Protein (1) SARS-CoV (11) Separase (1) Ser/Thr Protease (2) Smo (1) STAT (2) STING (2) TNF Receptor (1) TRP Channel (3) TrxR (1) Virus Protease (2) YAP (1)
By Research Areas:	Cancer (79) Cardiovascular Disease (3) Infection (37) Inflammation/Immunology (38) Metabolic Disease (31) Neurological Disease (26)
Click Chemistry:	TCO (1) Alkynes (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0078

DCIA

Fluorescent Dye Others

DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein .

DCIA	Fluorescent Dye	Others
DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein .

HY-134495

*N-Acetyl-L-cysteine* ethyl ester** 3 Publications Verification N-Acetylcysteine ethyl ester; NACET	Reactive Oxygen Species	Metabolic Disease
N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H₂S) and can be used as an H₂S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant .

HY-115890

Thiocysteine	Reactive Oxygen Species	Others
Thiocystine is the trisulfide analog of cysteine, it can modify cysteine in proteins. Thiocystine is an activator for aminolevulinate synthetase. Thiocystine can be used for cysteine metabolism research .

HY-135113

Lanthionine	Amino Acid Derivatives	Others
Lanthionine is a cysteine derivative. Lanthionine is linked by a disulfide bond formed by an oxidation reaction between two cysteine residues .

HY-115454

GB111-NH2

Cathepsin Metabolic Disease

GB111-NH2 is a cysteine cathepsin inhibitor and can be used in cancer research .

GB111-NH2	Cathepsin	Metabolic Disease
GB111-NH2 is a cysteine cathepsin inhibitor and can be used in cancer research .

HY-134517

Fmoc-HoCys(ACM)-OH	Amino Acid Derivatives	Others
Fmoc-HoCys(ACM)-OH, a homolog of cysteine, is synthesized from L-methionine. Fmoc-HoCys(ACM)-OH also can be used for the synthesis of solid phase peptide .

HY-W087027

Maleimide-NOTA

Others Cancer

Maleimide-NOTA is a chelator for the labeling of peptides and antibodies. Maleimide-NOTA can react with cysteine .

Maleimide-NOTA	Others	Cancer
Maleimide-NOTA is a chelator for the labeling of peptides and antibodies. Maleimide-NOTA can react with cysteine .

HY-Y0241

2-Cyanopyrimidine	Cathepsin	Metabolic Disease
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC₅₀ of 170 nM. 2-Cyanopyrimidine is used for osteoporos .

HY-B0393

Fudosteine 1 Publications Verification	Amino Acid Derivatives	Inflammation/Immunology
Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Endogenous Metabolite	Metabolic Disease
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-134222A

N-Acetylserine N-Acetyl-L-serine	Endogenous Metabolite	Others
N-Acetylserine (N-Acetyl-L-serine) can bind to CysB apoprotein. N-acetylserine is the physiological inducer of cysteine biosynthesis. N-Acetylserine can stimulate in vitro cysJIH transcription .

HY-157203

*Cholic acid-cysteine-cyanuric chloride complex*	Others	Others
Cholic acid-cysteine-cyanuric chloride complex is a hapten linker molecule comprising of the antigen, cholic acid and the reactive group for covalent attachment, cyanuric chloride .

HY-D0807

5-IAF 5-Iodoacetamidofluorescein	Fluorescent Dye	Cancer
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-115454A

GB111-NH2 hydrochloride

Cathepsin Others

GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor, and can be used for cancer study .

GB111-NH2 hydrochloride	Cathepsin	Others
GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor, and can be used for cancer study .

HY-D0152

Tetramethylrhodamine-6-maleimide	Fluorescent Dye	Others
Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time .

HY-105940

IQB-782	Amino Acid Derivatives	Cardiovascular Disease
IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an K_i(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity .

HY-P5071

EcAMP3	Bacterial	Infection
EcAMP3 is a hairpin-like peptide. EcAMP3 has antifungal and antibacterial activity. EcAMPs precursor family contains seven *identical cysteine* motifs**: C1XXXC2(11–13)C3XXXC4 .

HY-151505

CysOx2	Fluorescent Dye	Others
CysOx2 is a reaction-based fluorogenic probe for sulfenic acid (Ex/Em: 394/535 nm). CysOx2 can be used for detecting protein cysteine oxidation in living cells .

HY-W790014

Z-FG-NHO-BzOME

Cathepsin Infection

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-E70226

Cathepsin S, human CTSS	Others	Cardiovascular Disease Inflammation/Immunology Cancer
Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease .

HY-113402

Gamma-glutamylcysteine γ-Glu-Cys	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-143345

EN523

Others Cancer

EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1 .

EN523	Others	Cancer
EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1 .

HY-108137

Z-LVG-CHN2 2 Publications Verification	Cathepsin HSV SARS-CoV	Infection Inflammation/Immunology
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-14645

(-)-DHMEQ 25+ Cited Publications Dehydroxymethylepoxyquinomicin	NF-κB	Inflammation/Immunology Cancer
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity .

HY-121539

Supercinnamaldehyde	TRP Channel	Neurological Disease
Supercinnamaldehyde is a potent transient receptor potential ankyrin 1 (TRPA1) activator with an EC₅₀ value of 0.8 μM. Supercinnamaldehyde activates TRPA1 ion channels through covalent modification of cysteines .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Cathepsin	Others
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-149933

AM841	Cannabinoid Receptor	Neurological Disease
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility .

HY-151523

KRas G12R inhibitor 1	Ras	Cancer
KRas G12R inhibitor 1 (compound 3) is a KRas G12R selective covalent inhibitor that exploits the strong nucleophilicity of mutant cysteines and binds irreversibly in the Switch II region of K-Ras. KRas G12R inhibitor 1 can be used in cancer research .

HY-P4101

Cys(Npys)-TAT (47-57)	HIV	Infection
Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .

HY-148207

S-Benzylglutathione	Amino Acid Derivatives	Metabolic Disease
S-Benzylglutathione is a competitive glutathionase inhibitor. S-Benzylglutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-Benzylglutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system .

HY-130412

FlAsH-EDT2 1 Publications Verification	Fluorescent Dye	Others
FlAsH-EDT2 is a protein labeling reagent. FlAsH-EDT2 also is a membrane-permeant fluorogenic biarsenicals. FlAsH-EDT2 binds to CCXXCC motifs and non-specifically to endogenous cysteine-rich proteins. FlAsH-EDT2 can be useful only for labeling those recombinant proteins that express at a very high level .

HY-108137A

Z-L(D-Val)G-CHN2	Cathepsin HSV SARS-CoV	Infection
Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-W011618

N-(9-Acridinyl)maleimide	Fluorescent Dye	Others
N-(9-Acridinyl)maleimide is a maleimide type fluorescent thiol reagent. N-(9-Acridinyl)maleimide shows no substantial fluorescence but its coupling products with thiol compounds exhibit strong blue fluorescence. N-(9-Acridinyl)maleimide is used for fluorometrical analysis of cysteine and glutathione .

HY-147774

NAAA-IN-2	Others	Inflammation/Immunology
NAAA-IN-2 (Compound 9) is a potent and selective inhibitor of NAAA with an IC₅₀ of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-2 has the potential for the research of inflammation and pain .

HY-147773

NAAA-IN-1	Others	Inflammation/Immunology
NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC₅₀ of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-1 has the potential for the research of inflammation and pain .

HY-147775

NAAA-IN-3	Others	Inflammation/Immunology
NAAA-IN-3 (Compound 17a) is a potent and selective inhibitor of NAAA with an IC₅₀ of 50 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). NAAA-IN-3 has the potential for the research of inflammation and pain .

HY-119293

K777 1 Publications Verification	Cathepsin CCR Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Cancer
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

HY-143714

Cathepsin K inhibitor 2	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .

HY-148208

S-(p-Nitrobenzyl)glutathione	Amino Acid Derivatives	Metabolic Disease
S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system .

HY-P5681

Human α-Defensin 6	Bacterial	Infection Inflammation/Immunology
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .

HY-128971

LHVS	Cathepsin Parasite	Infection Neurological Disease
LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC₅₀ of 10 μM .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, *cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-18234A

Leupeptin hemisulfate 25+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, *cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N11085

Isophysalin A	NO Synthase IKK	Inflammation/Immunology
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-W002074

D-Cysteine hydrochloride

Amino Acid Derivatives Others

D-Cysteine hydrochloride is a cysteine derivative .
HY-W055811

D-Cysteine hydrochloride hydrate

Amino Acid Derivatives Others

D-Cysteine hydrochloride hydrate is a cysteine derivative .
HY-17541

Cysteine Protease inhibitor

3 Publications Verification

Cathepsin Others

Cysteine Protease inhibitor is an inhibitor of cysteine protease.
HY-17541A

Cysteine Protease inhibitor hydrochloride

3 Publications Verification

Cathepsin Others

Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease.
HY-Y1875

L-Cysteine ethyl ester HCl

Ethyl cysteinate hydrochloride
Amino Acid Derivatives Others

L-Cysteine ethyl ester HCl is a cysteine derivative .

*D-Cysteine* hydrochloride**	Amino Acid Derivatives	Others
D-Cysteine hydrochloride is a cysteine derivative .

Cat. No.	Product Name

HY-L153

Cysteine Targeted Covalent Library

4522 compounds

Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds.

To meet the development needs of covalent inhibitors targeting cysteine, MCE has designed a unique collection of 4522 compounds with different covalent warheads that target cysteine. The MCE Cysteine Targeted Covalent Library is designed using the following covalent warheads: Acrylamides, Propiolic acid ester, Dimethylamine functionalized acrylamides, Chloroacetamides, Acrylonitrile, 2-Cyanoacrylamide, Aziridine, Haloacetamide, etc.

HY-L154

Cysteine Targeted Covalent Fragment Library

3164 compounds

Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds.

To meet the development needs of covalent inhibitors targeting cysteine, MCE has designed a unique collection of 3164 fragments with different covalent warheads that target cysteine. The MCE Cysteine Targeted Covalent Fragment Library is designed using the following covalent warheads: Acrylamides, Propiolic acid ester, Dimethylamine functionalized acrylamides, Chloroacetamides, Acrylonitrile, 2-Cyanoacrylamide, Aziridine, Haloacetamide, etc. All fragments are pre-filtered with the Rule of Three restrictions which can be used for fragment-based covalent drug development.

HY-L175

Inflammasomes related Compound Library

67 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 67 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

HY-L081

Phosphatase Inhibitor Library

132 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 132 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Type

HY-D0078

DCIA

Fluorescent Dyes/Probes

DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein .

HY-D0807

5-IAF 5-Iodoacetamidofluorescein	Fluorescent Dyes/Probes
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .

HY-W011618

N-(9-Acridinyl)maleimide	Fluorescent Dyes/Probes
N-(9-Acridinyl)maleimide is a maleimide type fluorescent thiol reagent. N-(9-Acridinyl)maleimide shows no substantial fluorescence but its coupling products with thiol compounds exhibit strong blue fluorescence. N-(9-Acridinyl)maleimide is used for fluorometrical analysis of cysteine and glutathione .

HY-D1423

Dibromobimane

Fluorescent Dyes/Probes

Dibromobimane is a thiol-selective fluorescent imaging agent. Dibromobimane is used to crosslink cysteine- and homocysteine-containing peptides .

HY-D0152

Tetramethylrhodamine-6-maleimide	Fluorescent Dyes/Probes
Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time .

HY-P2065

Ac-VEID-AMC

Fluorescent Dyes/Probes

Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Dyes
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

HY-D1403

L-Biotin-NH-5MP	Protein Labeling
L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-135056

MitoTracker Green FM 3 Publications Verification	Fluorescent Dyes/Probes
Mito-Tracker Green is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm.

HY-D1406

L-Biotin-NH-5MP-Br	Protein Labeling
L-Biotin-NH-5MP-Br is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Fluorescent Dye
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

HY-D1363

BDP R6G maleimide

Fluorescent Dyes/Probes

BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

HY-D1404

5MP-Propargyl

Protein Labeling

5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1407

Br-5MP-Propargyl

Protein Labeling

Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Type

HY-138540

1-Dodecylimidazole 1 Publications Verification N-Dodecylimidazole	Cell Assay Reagents
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

HY-P2780

Cathepsin B	Biochemical Assay Reagents
Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) .

HY-W009356A

L-Cystine hydrochloride	Biochemical Assay Reagents
L-Cystine hydrochloride is an amino acid. L-Cystine is converted to L-Cysteine in the body. Moreover, L-Cystine/L-Cysteine conversion system is a channel on the cell membrane, which can maintain the internal REDOX homeostasis of E. coli .

HY-E70160

Protein O-Fucosyltransferase 1 EC:2.4.1.221; POFUT1	Enzyme Substrates
Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a Glycosyltransferase containing the cysteine-rich motifs as the acceptor sugar and GDP-fucose as the donor .

HY-118563

Farnesylthioacetic acid	Biochemical Assay Reagents
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine, which is a prenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase) competitive inhibitors. It also inhibits the methylation of farnesylated and geranylgeranylated substrates.

HY-148905

p-Aminophenylmercuric acetate

Biochemical Assay Reagents

p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Biochemical Assay Reagents
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

HY-E70018

Picornain 3C

Biochemical Assay Reagents

Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses .

Cat. No.	Product Name	Target	Research Area

HY-W790014

Z-FG-NHO-BzOME

Cathepsin Infection

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-135113

Lanthionine	Amino Acid Derivatives	Others
Lanthionine is a cysteine derivative. Lanthionine is linked by a disulfide bond formed by an oxidation reaction between two cysteine residues .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P5071

EcAMP3	Bacterial	Infection
EcAMP3 is a hairpin-like peptide. EcAMP3 has antifungal and antibacterial activity. EcAMPs precursor family contains seven *identical cysteine* motifs**: C1XXXC2(11–13)C3XXXC4 .

HY-P2780

Cathepsin B	Peptides	Others
Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) .

HY-P4101

Cys(Npys)-TAT (47-57)	HIV	Infection
Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .

HY-P5681

Human α-Defensin 6	Bacterial	Infection Inflammation/Immunology
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, *cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-W002074

D-Cysteine hydrochloride

Amino Acid Derivatives Others

D-Cysteine hydrochloride is a cysteine derivative .
HY-W055811

D-Cysteine hydrochloride hydrate

Amino Acid Derivatives Others

D-Cysteine hydrochloride hydrate is a cysteine derivative .
HY-Y1875

L-Cysteine ethyl ester HCl

Ethyl cysteinate hydrochloride
Amino Acid Derivatives Others

L-Cysteine ethyl ester HCl is a cysteine derivative .
HY-W009682

S-(Acetamidomethyl)-L-cysteine hydrochloride

Amino Acid Derivatives Others

S-(Acetamidomethyl)-L-cysteine hydrochloride is a cysteine derivative .
HY-W048286

S-Allyl-D-cysteine

Amino Acid Derivatives Others

S-Allyl-D-cysteine is a cysteine derivative .
HY-W141791

S-tert-Butylmercapto-L-cysteine

Amino Acid Derivatives Others

S-tert-Butylmercapto-L-cysteine is a cysteine derivative .
HY-W014238

S-tert-Butyl-L-cysteine hydrochloride

Amino Acid Derivatives Others

S-tert-Butyl-L-cysteine hydrochloride is a cysteine derivative .
HY-W129448

N-Boc-S-benzyl-D-cysteine

Amino Acid Derivatives Others

N-Boc-S-benzyl-D-cysteine is a cysteine derivative .
HY-W004153

S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine

Amino Acid Derivatives Others

S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine is a cysteine derivative .
HY-111592

S-(5′-Adenosyl)-L-cysteine

Amino Acid Derivatives Others

S-(5′-Adenosyl)-L-cysteine is a cysteine derivative .
HY-W048727

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-cysteine

Amino Acid Derivatives Others

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-cysteine is a cysteine derivative .

HY-W142140

N-Methyl-DL-valine N-Methylvaline	Amino Acid Derivatives	Others
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .

HY-W048708

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-methyl-L-cysteine

Amino Acid Derivatives Others

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-methyl-L-cysteine is a cysteine derivative .

HY-W009008

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butyl)-L-cysteine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butyl)-L-cysteine is a cysteine derivative .

HY-W023145

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butylthio)-L-cysteine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butylthio)-L-cysteine is a cysteine derivative .

HY-W036322

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-S-trityl-L-cysteine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-S-trityl-L-cysteine is a cysteine derivative .

HY-139093

Paracetamol-cysteine	Peptides	Others
Paracetamol-cysteine is a Paracetamol-cysteine Paracetamol protein adduct (PPA) and is formed when paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

HY-W141774

S-(2-Carboxyethyl)-L-cysteine S-Carboxyethylcysteine	Peptides	Metabolic Disease
S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine) is a non-protein (modified) sulfur amino acid. S-(2-Carboxyethyl)-L-cysteine is present in Acacia seed. S-(2-Carboxyethyl)-L-cysteine can affect the seed’s protein use in rats. S-(2-Carboxyethyl)-L-cysteine suppresses the methionine-induced growth rate, and has a negative effect on the plasma amino acid levels in rats .

HY-122526

Thialysine hydrochloride

Amino Acid Derivatives Others

Thialysine (hydrochloride) is a cysteine derivative .

HY-W037120

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-((4-methoxyphenyl)diphenylmethyl)-D-cysteine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-((4-methoxyphenyl)diphenylmethyl)-D-cysteine is a cysteine derivative .

HY-W013940

DL-Cystine

Amino Acid Derivatives Others

DL-Cystine is a cysteine derivative .
HY-W141770

DL-Phenylmercapturic Acid

Amino Acid Derivatives Others

DL-Phenylmercapturic Acid is a cysteine derivative .

HY-W018865

Methyl D-cysteinate hydrochloride (S)-Cysteine methyl ester hydrochloride; Methyl D-cysteinate hydrochloride	Amino Acid Derivatives	Others
Methyl D-cysteinate hydrochloride is a cysteine derivative .

HY-23174

Methyl acetyl-L-cysteinate

Amino Acid Derivatives Others

Methyl acetyl-L-cysteinate is a cysteine derivative .
HY-W013651

H-DL-Cys.HCl

Amino Acid Derivatives Others

H-DL-Cys.HCl is a cysteine derivative .

HY-W048681

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(4-(tert-butoxy)-4-oxobutyl)-L-cysteine	Amino Acid Derivatives	Others
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(4-(tert-butoxy)-4-oxobutyl)-L-cysteine is a cysteine derivative .

HY-134852

Fmoc-Cys(STmp)-OH

Amino Acid Derivatives Others

Fmoc-Cys(STmp)-OH is a cysteine derivative .
HY-W141779

Boc-Cys(Npys)-OH

Amino Acid Derivatives Others

Boc-Cys(Npys)-OH is a cysteine derivative .
HY-W141786

L-Glutamic acid hemimagnesium salt tetrahydrate

Amino Acid Derivatives Others

L-Glutamic acid hemimagnesium salt tetrahydrate is a cysteine derivative .
HY-W041857

Boc-Cys(tBu)-OH

Amino Acid Derivatives Others

Boc-Cys(tBu)-OH is a cysteine derivative .
HY-W041997

H-Cys(Z)-OH

Amino Acid Derivatives Others

H-Cys(Z)-OH is a cysteine derivative .
HY-W011773

H-Cys(Bzl)-OMe.HCl

Amino Acid Derivatives Others

H-Cys(Bzl)-OMe.HCl is a cysteine derivative .
HY-W012075

H-Cys(pMeOBzl)-OH

Amino Acid Derivatives Others

H-Cys(pMeOBzl)-OH is a cysteine derivative .
HY-W013118

Fmoc-Cys(pMeOBzl)-OH

Amino Acid Derivatives Others

Fmoc-Cys(pMeOBzl)-OH is a cysteine derivative .
HY-W013143

Fmoc-Cys(Acm)-OH

Amino Acid Derivatives Others

Fmoc-Cys(Acm)-OH is a cysteine derivative .
HY-W007798

Fmoc-Cys(Trt)-OH

Amino Acid Derivatives Others

Fmoc-Cys(Trt)-OH is a cysteine derivative .
HY-W014329

H-Cys(Bzl)-OH

Amino Acid Derivatives Others

H-Cys(Bzl)-OH is a cysteine derivative .

HY-113084

*L-Cysteine* S-sulfate**	iGluR Endogenous Metabolite	Neurological Disease
L-Cysteine S-sulfate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptor agonist. L-Cysteine S-sulfate is the substrate for cystine lyase, and can be used in mass spectrometry operations .

HY-43973

N-(tert-Butoxycarbonyl)-S-butylhomocysteine

Amino Acid Derivatives Others

N-(tert-Butoxycarbonyl)-S-butylhomocysteine is a cysteine derivative .
HY-W050803

H-D-Cys(Bzl)-OH

Amino Acid Derivatives Others

H-D-Cys(Bzl)-OH is a cysteine derivative .
HY-W053550

H-D-Cys(Trt)-OH

Amino Acid Derivatives Others

H-D-Cys(Trt)-OH is a cysteine derivative .
HY-W013734

N,N'-Di-BOC-L-cystine

Amino Acid Derivatives Others

N,N'-Di-BOC-L-cystine is a cysteine derivative .

Cat. No.	Product Name	Target	Research Area

HY-P990087

Zovostotug

Inhibitory Antibodies Inflammation/Immunology Cancer

Zovostotug is a human CD163 (scavenger receptor cysteine-rich (SRCR) type 1 M130) mAb .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-134222A

N-Acetylserine N-Acetyl-L-serine	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetylserine (N-Acetyl-L-serine) can bind to CysB apoprotein. N-acetylserine is the physiological inducer of cysteine biosynthesis. N-Acetylserine can stimulate in vitro cysJIH transcription .

HY-113402

Gamma-glutamylcysteine γ-Glu-Cys	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-18234A

Leupeptin hemisulfate 25+ Cited Publications	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, *cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-N11085

Isophysalin A	Structural Classification Natural Products Source classification Plants Solanaceae Alkekengi officinarum Moench	NO Synthase IKK
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-W018555

D-Cysteine	Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite Bacterial
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis* .

HY-111827

S-1-Propenyl-L-cysteine 3 Publications Verification	Cardiovascular Disease Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Allium sativum Linn. Plants Disease Research Fields	Others Histamine Receptor
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model . S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway . S-1-Propenyl-L-cysteine is orally active.

HY-W016715

*L-Cysteine* hydrochloride hydrate** 3 Publications Verification	Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans .

HY-45609

*L-Cysteine* S-sulfate sodium hydrate**	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate sodium hydrate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .

HY-113084

*L-Cysteine* S-sulfate**	Structural Classification Natural Products Immune System Disorder Neurological Disease Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptor agonist. L-Cysteine S-sulfate is the substrate for cystine lyase, and can be used in mass spectrometry operations .

HY-100787

*L-Cysteine* S-sulfate sodium**	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	iGluR Endogenous Metabolite
L-Cysteine S-sulfate sodium is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .

HY-N10123

Indolokine A5	Alkaloids Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Aryl Hydrocarbon Receptor
Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist .

HY-101409

O-Acetylserine O-Acetyl-L-serine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

HY-147065

γ-L-Glutamyl-S-allyl-L-cysteine	Liliaceae Ketones, Aldehydes, Acids Source classification Plants Amaryllidaceae A．Sativam L. var．Viviparum Regel	Others
γ-L-Glutamyl-S-allyl-L-cysteine is a naturally occurring organosulfur compound found in garlic .

HY-P1645

Papain 5+ Cited Publications	Carica papaya L. Structural Classification Natural Products Classification of Application Fields Source classification Caricaceae Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-111826

γ-Glutamyl-S-1-propenyl cysteine 1 Publications Verification	Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Allium sativum Linn. Plants Disease Research Fields	Others
γ-Glutamyl-S-1-propenyl cysteine is a compound isolated from garlic .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-100803

Hypotaurine 1 Publications Verification 2-Aminoethanesulfinic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant .

HY-W251393

S-(2-Carboxypropyl)-L-cysteine β-Isobuteine	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
S-(2-Carboxypropyl)-L-cysteine (β-Isobuteine) is a urine metabolite, a metabolic marker of leigh-like syndrome .

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Reactive Oxygen Species
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-111825A

(R)-1-PeCSO Isoalliin; trans-(+)-S-1-Propenyl-L-cysteine sulfoxide	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Allium cepa L. Plants Disease Research Fields	Others
(R)-1-PeCSO (trans-(+)-S-1-Propenyl-L-cysteine sulfoxide) is the most abundant flavor precursor in onions .

HY-W013573

S-Allyl-L-cysteine	Natural Products Liliaceae Classification of Application Fields Neurological Disease Anti-aging Source classification Metabolic Disease Allium sativum Linn. Plants Disease Research Fields Inflammation/Immunology Cancer	Apoptosis
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-130347

H2S Donor 5a	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H2S Donor 5a is a cysteine-activated H2S donor. H₂S plays important roles in biological systems. H2S Donor 5a is a useful tool in H₂S research .

HY-N9413

γ-Glutamyl-S-allylcysteine L-γ-Glutamyl-(S)-Allyl-Cysteine	Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Allium sativum Linn. Plants Disease Research Fields	Others
γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a naturally occurring organosulfur compound found in garlic. γ-Glutamyl-S-allylcysteine has antiglycative effect and shows radical-scavenging and metal-chelating capacities .

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-W017464

NAPQI	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-119970

Helenalin 4 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	Infection Andrographis paniculata (Burm. F.) Nees Classification of Application Fields Acanthaceae Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB SARS-CoV Influenza Virus Autophagy Parasite
Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-125773

β-cyano-L-Alanine Beta-cyano-l-alanine	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-cyano-L-Alanine (Beta-cyano-l-alanine), a nitrile of widespread occurrence in higher plants, is enzymatically produced by cyanoalanine synthase from cyanide and cysteine as substrates . β-cyano-L-Alanine abolishes the protective effect of ethanol on cerebral ischemia/reperfusion (I/R) injury .

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis
Stem bromelain (EC 3.4.22.32) is a cysteine proteinase, isolated from pineapple (Ananas comosus) stem. Stem bromelain is a major bromelain, which exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Stem bromelain has in vivo antitumoral and antileukemic activity, as well as antimetastatic action .

HY-B0215

Acetylcysteine Maximum Cited Publications 311 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities .

HY-N0005

Curcumin 60+ Cited Publications Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Food Research Microorganisms Sunscreen Phenols Polyphenols Pigments Cosmetic Research Curcuma longa Disease Research Fields Cancer Zingiberaceae	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

Cat. No.	Product Name	Chemical Structure

HY-Y0337S5

*L-Cysteine-d3*
L-Cysteine-d₃ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S6

*L-Cysteine-d2*
L-Cysteine-d₂ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S1

*L-Cysteine-15N*
L-Cysteine- ¹⁵N is the ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S4

*L-Cysteine-13C3*
L-Cysteine- ¹³C₃ is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S2

*L-Cysteine-3-13C*
L-Cysteine-3- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S3

*L-Cysteine-1-13C*
L-Cysteine-1- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S

*L-Cysteine-13C3,15N*
L-Cysteine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S7

*L-Cysteine-d3,15N*
L-Cysteine-d₃, ¹⁵N is the deuterium and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-144355S

N-Acetyl-S-propyl-L-cysteine-d7

N-Acetyl-S-propyl-L-cysteine-d₇ is the deuterium labeled N-Acetyl-S-propyl-L-cysteine.
HY-W101367S

N-Acetyl-S-benzyl-L-cysteine-d5

N-Acetyl-S-benzyl-L-cysteine-d₅ is the deuterium labeled N-Acetyl-S-benzyl-L-cysteine.
HY-139474S

N-Acetyl-S-(carbamoylethyl)-L-cysteine-d3

N-Acetyl-S-(carbamoylethyl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(carbamoylethyl)-L-cysteine[1].
HY-141718S

N-Acetyl-S-(trichlorovinyl)-L-cysteine-d3

N-Acetyl-S-(trichlorovinyl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(trichlorovinyl)-L-cysteine[1].
HY-139474S1

N-Acetyl-S-(carbamoylethyl)-L-cysteine-d4

N-Acetyl-S-(carbamoylethyl)-L-cysteine-d₄ is the deuterium labeled N-Acetyl-S-(carbamoylethyl)-L-cysteine[1].
HY-144414S

N-Acetyl-S-ethyl-L-cysteine-d5

N-Acetyl-S-ethyl-L-cysteine-d₅ is the deuterium labeled N-Acetyl-S-ethyl-L-cysteine[1].
HY-139491S

N-(Acetyl-d3)-S-benzyl-L-cysteine

N-(Acetyl-d₃)-S-benzyl-L-cysteine is the deuterium labeled N-(Acetyl)-S-benzyl-L-cysteine[1].
HY-144408S

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine-d3

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine[1].

HY-146716S

*N-Acetyl-S-(N-methyl-carbamoyl)-L-cysteine-d3 dicyclohexylamine*
N-Acetyl-S-(N-methyl-carbamoyl)-L-cysteine-d₃ (dicyclohexylamine) is the deuterium labeled N-Acetyl-S-(N-methyl-carbamoyl)-L-cysteine.

HY-146659S

S-Phenyl-DL-cysteine-3,3-d2

S-Phenyl-DL-cysteine-3,3-d₂ is the deuterium labeled S-Phenyl-DL-cysteine-3,3[1].
HY-151215S

S-Sulfo-DL-cysteine-2,3,3-d3-1

S-Sulfo-DL-cysteine-2,3,3-d₃-1 is the deuterium labeled S-Sulfo-DL-cysteine[1].
HY-146656S

S-Sulfo-DL-cysteine-2,3,3-d3

S-Sulfo-DL-cysteine-2,3,3-d₃ is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.

HY-146717S

*N-Acetyl-S-(3-hydroxypropyl)-L-cysteine-d6 dicyclohexylamine*
N-Acetyl-S-(3-hydroxypropyl)-L-cysteine-d₆ (dicyclohexylamine) is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl)-L-cysteine.

HY-144407S

N-Acetyl-S-(2-carboxyethyl)-L-cysteine-d3

N-Acetyl-S-(2-carboxyethyl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(2-carboxyethyl)-L-cysteine[1].
HY-144409S

N-Acetyl-S-(2-cyanoethyl)-L-cysteine-d3

N-Acetyl-S-(2-cyanoethyl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(2-cyanoethyl)-L-cysteine[1].
HY-151183S

N-Acetyl-S-phenyl-DL-cysteine-3,3-d2

N-Acetyl-S-phenyl-DL-cysteine-3,3-d₂ is the deuterium labeled N-Acetyl-S-phenyl-DL-cysteine[1].

HY-144406S

*N-Acetyl-S-(3-hydroxypropyl)cysteine-d3 dicyclohexylammonium*
N-Acetyl-S-(3-hydroxypropyl)cysteine-d₃ dicyclohexylammonium is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl)cysteine (dicyclohexylammonium) .

HY-144362S

N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine-d3

N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine[1].

HY-144365S

*N-Acetyl-S-(2-hydroxypropyl)cysteine-d3 dicyclohexylammonium*
N-Acetyl-S-(2-hydroxypropyl)cysteine-d₃ (dicyclohexylammonium) is the deuterium labeled N-Acetyl-S-(2-hydroxypropyl)cysteine (dicyclohexylammonium)[1].

HY-132805S

*N-Acetyl-S-(2-hydroxyethyl)-L-cysteine-d4 dicyclohexylamine salt*
N-Acetyl-S-(2-hydroxyethyl)-L-cysteine-d₄ (dicyclohexylamine) is the deuterium labeled N-Acetyl-S-(2-hydroxyethyl)-L-cysteine dicyclohexylamine salt[1].

HY-W766569

N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine-13C,d3

N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine- ¹³C,d₃ is ¹³C and deuterated labeled N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine.
HY-W012850S1

DL-Cysteine-d1

DL-Cysteine-d₁ is the deuterated labeled 2-Amino-3-mercaptopropanoic acid (HY-W012850). 2-Amino-3-mercaptopropanoic acid is a cysteine derivative .
HY-144364S

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d3

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d₃ is the deuterium labeled N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine[1].
HY-114976S

N-Acetyl-S-allyl-L-cysteine-d3

N-Acetyl-S-allyl-L-cysteine-d₃ is the deuterium labeled Fluometuron[1].
HY-W010209S

DL-Histidine-13C6,15N3

DL-Histidine- ¹³C₆, ¹⁵N₃ N-Acetyl-S-allyl-L-cysteine
HY-B0035S2

Sulfamethazine-13C6

Sulfamethazine- ¹³C₆ is a ¹³C-labeled n-Acetyl-s-methyl-l-cysteine[1].
HY-W587731S

N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-d7

N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-d₇ is a deuterium labeled compound.
HY-W214059S

N-Acetyl-S-methyl-L-cysteine-d3

N-Acetyl-S-methyl-L-cysteine-d₃ is the deuterium labeled C18:1-Ceramide[1].
HY-W007798S1

Fmoc-Cys(Trt)-OH-d2

Fmoc-Cys(Trt)-OH-d₂ is the deuterium labeled Fmoc-Cys(Trt)-OH. Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative[1].

HY-N0771S6

*L-Cysteine-13C3,15N,d3*
L-Cysteine- ¹³C₃, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

HY-34477S1

2-Iodoacetamide-d4
2-Iodoacetamide-d₄ is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].

HY-W141772S

N-Acetyl-S-benzyl-2,3,4,5,6-d5-DL-cysteine

N-Acetyl-S-benzyl-2,3,4,5,6-d₅-DL-cysteine is the deuterium labeled N-Acetyl-S-benzyl-2,3,4,5,6-d5-DL-cyste[1].

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

HY-19528S

SAH-d4
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-144354S

*S-Benzyl-DL-cysteine-2,3,3-d3*
S-Benzyl-DL-cysteine-2,3,3-d₃ is a deuterium labeled Benzylcysteine. Benzylcysteine is an ASCT2 inhibitor that binds to ASCT2 with an apparent Ki of 780 μM. Benzylcysteine inhibit ASCT2 function based on a competitive mechanism, indicating that Benzylcysteine binds to the substrate-binding site of ASCT2[1].

HY-19528S1

SAH-13C5
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S2

SAH-13C10
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

Cat. No.	Product Name		Classification

HY-136205

IA-Alkyne Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide		Alkynes
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative *cysteine-reactivity* profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

HY-120330

Nek2-IN-5		Alkynes
Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior . Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151696

TCO-PEG3-maleimide		TCO
TCO-PEG3-maleimide (TCO-PEG3-NEM) is a click chemistry reagent. TCO-PEG3-maleimide efficiently binds TCO (trans-cyclooctene) moiety to thiol-containing molecules (such as antibodies, cysteine-containing peptides) .

HY-D1404

5MP-Propargyl		Alkynes
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1407

Br-5MP-Propargyl		Alkynes
Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115715A

EN219-alkyne		Alkynes
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

cysteines

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products