1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Optovin

Optovin 

Cat. No.: HY-12809 Purity: 99.28%
Handling Instructions

Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues.

For research use only. We do not sell to patients.

Optovin Chemical Structure

Optovin Chemical Structure

CAS No. : 348575-88-2

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10 mM * 1 mL in DMSO USD 106 In-stock
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10 mg USD 132 In-stock
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50 mg USD 456 In-stock
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Description

Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues[1].

In Vitro

Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM[1].
Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons[1].
Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Optovin (1-10 μM) causes light-dependent motor excitation in vivo[1].
Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice[1].
Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

315.41

Formula

C₁₅H₁₃N₃OS₂

CAS No.

348575-88-2

SMILES

O=C1NC(S/C1=C\C2=C(C)N(C3=CC=CN=C3)C(C)=C2)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (117.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1705 mL 15.8524 mL 31.7048 mL
5 mM 0.6341 mL 3.1705 mL 6.3410 mL
10 mM 0.3170 mL 1.5852 mL 3.1705 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.28%

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Keywords:

OptovinTRP ChannelTransient receptor potential channelsphotoactivatedTRPA1light-mediatedneuronalexcitationInhibitorinhibitorinhibit

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