Zovostotug
Based on 1 Customer Validation
Zovostotug (OR-2805) is a fully human IgG1 antibody that binds to CD163. Zovostotug binds to CD163 expressed on TAMs and M2-like macrophages. Zovostotug does not bind to other hematopoietic cells nor to a panel of human primary non-immune cells. Zovostotug canbe used for the study of lung cancer.
For research use only. We do not sell to patients.
- Purity: 98.726%
- CAS No.: 2756228-84-7
- Molecular Weight:149.111 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
CD163
Zovostotug (OR-2805) treatment reduces expression of cell-surface markers associated with tumor-promoting M2c-like macrophages. In co-culture assays, Zovostotug relieves the suppressive effect of M2 macrophages and results in increased T-cell activation and proliferation, upregulation of T-cell activation markers, and enhanced T-cell-mediated tumor cell killing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q86VB7-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized CD163 Protein, Human (HEK293, His-Avi, HY-P77884) can bind Zovostotug. The EC50 for this effect is 201 ng/mL. -
Flow cytometric analysis of 1X106 THP-1 cells with Zovostotug (HY-P990087, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2756228-84-7
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Appearance Liquid
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Molecular Weight 149.111 kDa
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Color Colorless to light yellow
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SMILES
[Zovostotug]
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Synonyms
OR-2805
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)