Zovostotug
Based on 1 Customer Validation
Zovostotug (OR-2805) is a fully human IgG1 antibody that binds to CD163. Zovostotug binds to CD163 expressed on TAMs and M2-like macrophages. Zovostotug does not bind to other hematopoietic cells nor to a panel of human primary non-immune cells. Zovostotug canbe used for the study of lung cancer.
For research use only. We do not sell to patients.
- Purity : 98.726%
- CAS No.: 2756228-84-7
- Molecular Weight:149.111 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD163
In Vitro
Zovostotug (OR-2805) treatment reduces expression of cell-surface markers associated with tumor-promoting M2c-like macrophages. In co-culture assays, Zovostotug relieves the suppressive effect of M2 macrophages and results in increased T-cell activation and proliferation, upregulation of T-cell activation markers, and enhanced T-cell-mediated tumor cell killing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Q86VB7-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized CD163 Protein, Human (HEK293, His-Avi, HY-P77884) can bind Zovostotug. The EC50 for this effect is 201 ng/mL. -
Flow cytometric analysis of 1X106 THP-1 cells with Zovostotug (HY-P990087, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2756228-84-7
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Appearance Liquid
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Molecular Weight 149.111 kDa
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Color Colorless to light yellow
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SMILES
[Zovostotug]
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Synonyms
OR-2805
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)