CD163 - CD163 molecule Gene

Also Known as M130; MM130; SCARI1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9332

About CD163

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,470,811-7,503,777 (from NCBI)

This gene has 11 transcripts (splice variants), 169 orthologues and 15 paralogues. Broad expression in appendix (RPKM 85.9), spleen (RPKM 66.5) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of Hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

CD163 Products (4)

mRNA	Protein	Name
NM_001370145.1	NP_001357074.1	scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor
NM_001370146.1	NP_001357075.1	scavenger receptor cysteine-rich type 1 protein M130 isoform c
NM_004244.6	NP_004235.4	scavenger receptor cysteine-rich type 1 protein M130 isoform a precursor
NM_203416.4	NP_981961.2	scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15479433	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	23555801	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	24942581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD163 Protein Structure

SRCR

0
200
400
600
800
1000
1156 a.a.

Protein Preferred Names	Protein Names
scavenger receptor cysteine-rich type 1 protein M130	hemoglobin scavenger receptor

CD163 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD163	Q86VB7	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	CD163	Q86VB7	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD163 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P77884	CD163 Protein, Human (HEK293, His-Avi)	Q86VB7-1 (S42-S1045)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700668	CD163 Protein, Human (Biotinylated, HEK293, His-Avi)	Q86VB7-1 (S42-S1045)	≥ 95%, as determined by reducing SDS-PAGE.

CD163 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81177	CD163 Antibody	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse
HY-P84660	CD163 Antibody (YA4357)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P84660A	CD163 Antibody (YA4357)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P86099	CD163 Antibody (YA5791)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Histiocytic Sarcoma	Malignant Histiocytosis
Necrobiosis Lipoidica	Oppenheim-Urbach Disease Necrobiosis Lipoidica Diabeticorum
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Spondylarthropathy	Spondylarthropathies
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Synovitis
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Granulomatous Dermatitis
Macrophage Activation Syndrome
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Chorioamnionitis
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Parovarian Cyst	Cyst, Fimbrial Embryonic Fimbrial Cyst
Reticulohistiocytic Granuloma	Reticulohistiocytoma Solitary Reticulohistiocytoma Solitary Histiocytoma Solitary Reticulohistiocytosis
Verruciform Xanthoma Of Skin	Verruciform Xanthoma Cutaneous Verruciform Xanthoma
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Pigmented Villonodular Synovitis	Diffuse Giant Cell Tumor Of Tenosynovium Villous Tenosynovitis Diffuse Pigmented Villonodular Synovitis Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Localized Pigmented Villonodular Synovitis Tgct Tsgct Tenosynovial Giant Cell Tumor Tenosynovial Giant Cell Tumors Synovitis Pigmented Villonodular Synovitis, Pigmented Villonodular Fibrous Histiocytoma Of Tendon Sheath Testicular Germ Cell Tumor Chronic Haemorrhagic Villous Synovitis Pvns - [Pigmented Villonodular Synovitis] Villonodular Synovitis
Interdigitating Dendritic Cell Sarcoma	Interdigitating Cell Sarcoma Dendritic Cell Sarcoma, Interdigitating Reticulum Cell Sarcoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Bone Benign Neoplasm
Liver Leiomyosarcoma	Leiomyosarcoma Of The Liver
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Lymphoproliferative Syndrome 1	LPFS1 Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 Combined Immunodeficiency Due To Itk Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Itk Deficiency Itk Deficiency
Balloon Cell Malignant Melanoma
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Atrial Septal Defect 8	ASD8 Atrial Heart Septal Defect 8 Septal Defect, Atrial, Type 8
Diabetes Mellitus	Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990087	Zovostotug		98.726%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-147089	PRRSV/CD163-IN-1	Inhibitor	98.28%	Unkown
HY-178945	KOR agonist 7		/	Unkown
HY-RS02192	CD163 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02193	CD163L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16958	Cd163 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23401	Cd163 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990349	Anti-CD19 Antibody	Inhibitor	99.91%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD163	VGNC	VGNC:70752
Mus musculus	CD163	MGD	MGI:2135946
Canis familiaris	CD163	VGNC	VGNC:38931
Rattus norvegicus	CD163	RGD	RGD:1310382
Felis catus	CD163	VGNC	VGNC:60586
Others	CD163	NCBI