L-Cysteine methyl ester hydrochloride
Based on 1 Customer Validation
L-Cysteine methyl ester hydrochloride is an antitussive, phlegmolytic agent used to relieve breathing difficulties caused by large amounts of phlegm. L-Cysteine methyl ester hydrochloride is a copper corrosion inhibitor used in various industrial studies.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 18598-63-5
- Formula: C4H10ClNO2S
- Molecular Weight:171.65
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
L-Cysteine methyl ester hydrochloride (100 nM-100 μM) stimulates the secretory activity of trachea secretory cells, while high concentration stimulates the synthesis of mucinous glycoprotein in submucosal glands. It has an obvious viscosity-reducing effect on secretory cell mucous[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley rat model[3]
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Dosage:500 μmol/kg
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Administration:10 mg/kg morphine i.v.,15 min later,500 μmol/kg L-CYSme and repeat after 15 min later.
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Result:Overcome the adverse effects of morphine on breathing, A-a gradient, and ABG chemistry in unanesthetized rats.
Chemical Information
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CAS No. 18598-63-5
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Appearance Solid
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Molecular Weight 171.65
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Formula C4H10ClNO2S
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Color White to off-white
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SMILES
N[C@@H](CS)C(OC)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (582.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Yanaura S, et al. Behavior of mucus glycoproteins of tracheal secretory cells following L-cysteine methyl ester treatment. J Pharmacobiodyn. 1982 Aug;5(8):603-10. [Content Brief]
[3]. Getsy PM, et al. L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats. Front Pharmacol. 2022 Sep 28;13:968378. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.8258 mL | 29.1290 mL | 58.2581 mL | 145.6452 mL |
| 5 mM | 1.1652 mL | 5.8258 mL | 11.6516 mL | 29.1290 mL | |
| 10 mM | 0.5826 mL | 2.9129 mL | 5.8258 mL | 14.5645 mL | |
| 15 mM | 0.3884 mL | 1.9419 mL | 3.8839 mL | 9.7097 mL | |
| 20 mM | 0.2913 mL | 1.4565 mL | 2.9129 mL | 7.2823 mL | |
| 25 mM | 0.2330 mL | 1.1652 mL | 2.3303 mL | 5.8258 mL | |
| 30 mM | 0.1942 mL | 0.9710 mL | 1.9419 mL | 4.8548 mL | |
| 40 mM | 0.1456 mL | 0.7282 mL | 1.4565 mL | 3.6411 mL | |
| 50 mM | 0.1165 mL | 0.5826 mL | 1.1652 mL | 2.9129 mL | |
| 60 mM | 0.0971 mL | 0.4855 mL | 0.9710 mL | 2.4274 mL | |
| 80 mM | 0.0728 mL | 0.3641 mL | 0.7282 mL | 1.8206 mL | |
| 100 mM | 0.0583 mL | 0.2913 mL | 0.5826 mL | 1.4565 mL |
L-Cysteine methyl ester hydrochloride Related Classifications
HY-B1038 Related Classifications
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