1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Maleimido-tri(ethylene glycol)-propionic acid

Maleimido-tri(ethylene glycol)-propionic acid (Synonyms: Mal-PEG3-acid)

Cat. No.: HY-130426
Handling Instructions

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation.

For research use only. We do not sell to patients.

Maleimido-tri(ethylene glycol)-propionic acid Chemical Structure

Maleimido-tri(ethylene glycol)-propionic acid Chemical Structure

CAS No. : 518044-40-1

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Description

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1].

IC50 & Target

Cleavable

 

In Vitro

Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].
ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].
ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1].
ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1].

Molecular Weight

301.29

Formula

C₁₃H₁₉NO₇

CAS No.

518044-40-1

SMILES

O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Maleimido-tri(ethylene glycol)-propionic acidMal-PEG3-acidADC LinkerAntibody-drug conjugates linkertrastuzumabADCneolymphostinlinkeranti-tumorInhibitorinhibitorinhibit

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Maleimido-tri(ethylene glycol)-propionic acid
Cat. No.:
HY-130426
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