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Cat. No.: HY-146649

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LmCPB-IN-1

LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7.

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CAS No.: 2151025-98-6
Formule: C₁₈H₃₀N₆O₂
Masse moléculaire:362.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

LmCPB-IN-1 Chemical Structure

CAS No.: 2151025-98-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7^[1].

IC₅₀ & Target

pKi: 9.7 (Leishmania mexicana cysteine protease B)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
LLC-MK2	CC₅₀	26.9 μM Compound: Neq0690	Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34095840]
U2OS	CC₅₀	26.9 μM Compound: Neq0690	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34095840]

Chemical Information

CAS No. 2151025-98-6
Masse moléculaire 362.47
Formule C₁₈H₃₀N₆O₂
SMILES

CC(C[C@@H](C(N(N(C#N)C)C)=O)NC(C1=CC(C(C)(C)C)=NN1C)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jean F R Ribeiro, et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorg Med Chem. 2020 Nov 15;28(22):115743. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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LmCPB-IN-1

Voir tous les produits spécifiques à Isoform Parasite

Voir tous les produits spécifiques à Isoform Cathepsin

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LmCPB-IN-1 Related Classifications

HY-146649 Related Classifications

Bioz

Keywords

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