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Cat. No.: HY-146649

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LmCPB-IN-1

LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7.

For research use only. We do not sell to patients.

CAS No.: 2151025-98-6
Formula: C₁₈H₃₀N₆O₂
Molecular Weight:362.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

LmCPB-IN-1 Chemical Structure

CAS No.: 2151025-98-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pK_i of 9.7^[1].

IC₅₀ & Target

pKi: 9.7 (Leishmania mexicana cysteine protease B)^[1]

All Parasite Isoforms :

All Cathepsin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
LLC-MK2	CC₅₀	26.9 μM Compound: Neq0690	Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34095840]
U2OS	CC₅₀	26.9 μM Compound: Neq0690	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34095840]

Chemical Information

CAS No. 2151025-98-6
Molecular Weight 362.47
Formula C₁₈H₃₀N₆O₂
SMILES

CC(C[C@@H](C(N(N(C#N)C)C)=O)NC(C1=CC(C(C)(C)C)=NN1C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jean F R Ribeiro, et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorg Med Chem. 2020 Nov 15;28(22):115743. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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LmCPB-IN-1

All Parasite Isoforms

All Cathepsin Isoforms