1. Autophagy
    Membrane Transporter/Ion Channel
  2. Autophagy
    Proton Pump
  3. EN6

EN6 

Cat. No.: HY-128892
Handling Instructions

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner.

For research use only. We do not sell to patients.

EN6 Chemical Structure

EN6 Chemical Structure

CAS No. : 1808714-73-9

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Description

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].

Molecular Weight

368.34

Formula

C₁₉H₁₄F₂N₄O₂

CAS No.

1808714-73-9

SMILES

O=C(C1=CN(C2=CC=CC=C2F)N=C1)NC3=CC=C(F)C(NC(C=C)=O)=C3

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