1. Autophagy
    Membrane Transporter/Ion Channel
  2. Autophagy
    Proton Pump
  3. EN6

EN6 

Cat. No.: HY-128892 Purity: 99.58%
Handling Instructions

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner.

For research use only. We do not sell to patients.

EN6 Chemical Structure

EN6 Chemical Structure

CAS No. : 1808714-73-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 340 In-stock
Estimated Time of Arrival: December 31
100 mg USD 510 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].

Molecular Weight

368.34

Formula

C₁₉H₁₄F₂N₄O₂

CAS No.

1808714-73-9

SMILES

O=C(C1=CN(C2=CC=CC=C2F)N=C1)NC3=CC=C(F)C(NC(C=C)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7149 mL 13.5744 mL 27.1488 mL
5 mM 0.5430 mL 2.7149 mL 5.4298 mL
10 mM 0.2715 mL 1.3574 mL 2.7149 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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EN6
Cat. No.:
HY-128892
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