1. Antibody-drug Conjugate/ADC Related
    Cytoskeleton
    Cell Cycle/DNA Damage
  2. Drug-Linker Conjugates for ADC
    Microtubule/Tubulin
  3. DM4-SPDP

DM4-SPDP 

Cat. No.: HY-126493
Handling Instructions

DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

For research use only. We do not sell to patients.

DM4-SPDP Chemical Structure

DM4-SPDP Chemical Structure

CAS No. : 2245698-48-8

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Description

DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate[1]. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

IC50 & Target[1]

Maytansinoids

 

Molecular Weight

981.57

Formula

C₄₅H₆₁ClN₄O₁₄S₂

CAS No.

2245698-48-8

SMILES

COC1=CC(C/C(C)=C/C=C/[[email protected]@H](OC)[[email protected]]2(O)NC(OC([[email protected]@H](C)[[email protected]]3[[email protected]](O3)(C)[[email protected]@H](OC([[email protected]](C)N(C(CCC(C)(C)SSCCC(ON4C(CCC4=O)=O)=O)=O)C)=O)CC5=O)C2)=O)=CC(N5C)=C1Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DM4-SPDPDrug-Linker Conjugates for ADCMicrotubule/TubulinInhibitorinhibitorinhibit

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DM4-SPDP
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