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Cat. No.: HY-126493A

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(R)-DM4-SPDP

(R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates.

For research use only. We do not sell to patients.

CAS No.: 2245698-48-8
Formula: C₄₅H₆₁ClN₄O₁₄S₂
Molecular Weight:981.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(R)-DM4-SPDP Chemical Structure

CAS No.: 2245698-48-8

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Biological Activity

Description

(R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates^[1].

All Drug-Linker Conjugates for ADC Isoforms :

Chemical Information

CAS No. 2245698-48-8
Molecular Weight 981.57
Formula C₄₅H₆₁ClN₄O₁₄S₂
SMILES

C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@@H](C)N(C)C(CCC(C)(C)SSCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@@]([C@@H]([C@](OC5=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N5)O)C)([H])O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Silvana T Tivadar, et al. Monoclonal Antibody Targeting Sialyl-di-Lewisa-Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential. Mol Cancer Ther. 2020 Mar;19(3):790-801. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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(R)-DM4-SPDP

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(R)-DM4-SPDP Related Classifications

HY-126493A Related Classifications