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Oxothiazolidinecarboxylic acid 

Cat. No.: HY-133105 Purity: >98.0%
Handling Instructions

Oxothiazolidinecarboxylic acid, an antioxidant, is a prodrug of cysteine that is inert until metabolized to cysteine intracellulary, thus stimulating glutathione synthesis.

For research use only. We do not sell to patients.

Oxothiazolidinecarboxylic acid Chemical Structure

Oxothiazolidinecarboxylic acid Chemical Structure

CAS No. : 19771-63-2

Size Price Stock Quantity
250 mg USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 95 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Oxothiazolidinecarboxylic acid, an antioxidant, is a prodrug of cysteine that is inert until metabolized to cysteine intracellulary, thus stimulating glutathione synthesis[1].

In Vivo

Oxothiazolidinecarboxylic acid treatment attenuates plantaris atrophy, restored glutathione levels, and increased catalase, Cu/Zn-SOD1, and Mn-SOD2 mRNA expression, but did not reduce other markers of oxidant stress or levels of these catabolic factors[1].

Animal Model: Male Sprague-Dawley rats (200-250 g, n= 6-7 rats/group)[1].
Dosage: 0.35% (w/v).
Administration: Added to their diets at a concentration of 0.35% (w/v) for the final 12 wk.
Result: Increased fiber CSAs compared to the non-supplemented, alcohol-fed group.
Molecular Weight

147.15

Formula

C₄H₅NO₃S

CAS No.

19771-63-2

SMILES

O=C([[email protected]]1NC(SC1)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1698.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7958 mL 33.9789 mL 67.9579 mL
5 mM 1.3592 mL 6.7958 mL 13.5916 mL
10 mM 0.6796 mL 3.3979 mL 6.7958 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (14.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (14.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (14.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Oxothiazolidinecarboxylic acidOthersInhibitorinhibitorinhibit

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Product name:
Oxothiazolidinecarboxylic acid
Cat. No.:
HY-133105
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