1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. CL2A

CL2A 

Cat. No.: HY-128945
Handling Instructions

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

For research use only. We do not sell to patients.

CL2A Chemical Structure

CL2A Chemical Structure

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Description

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].

IC50 & Target[1]

Cleavable

 

Molecular Weight

1062.21

Formula

C₅₀H₇₉N₉O₁₆

SMILES

O=C(NC1=CC=C(CO)C=C1)[[email protected]](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

CL2AADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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