N-Acetyl-D-cysteine

Name: N-Acetyl-D-cysteine
Brand: MedChemExpress
SKU: HY-136386
Rating: 4.5 (2 reviews)

Cat. No.: HY-136386 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway.

For research use only. We do not sell to patients.

N-Acetyl-D-cysteine Chemical Structure

CAS No. : 26117-28-2

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 83	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 83	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE N-Acetyl-D-cysteine

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Biological Activity
Purity & Documentation
References
Customer Review

Description

N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway^[1].

In Vitro

N-Acetyl-D-cysteine (20 mM; 1 hour pretreatment; 12 hours) does not increase intracellular GSH levels, but GSH monoester does. D-NAC can not enhance hypoxic apoptosis. This demonstrate that GSH rather than D-NAC or NAC is responsible for enhancing hypoxic apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

163.19

Formula

C₅H₉NO₃S

CAS No.

26117-28-2

Appearance

Solid

Color

White to off-white

SMILES

SC[C@H](C(O)=O)NC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1531.96 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1278 mL	30.6391 mL	61.2783 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (612.78 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB) HNMR (235 KB) MS (176 KB)

Handling Instructions (2659 KB)

References

[1]. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37. [Content Brief]

[2]. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol [Content Brief]

[3]. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.1278 mL	30.6391 mL	61.2783 mL	153.1957 mL
	5 mM	1.2256 mL	6.1278 mL	12.2557 mL	30.6391 mL
	10 mM	0.6128 mL	3.0639 mL	6.1278 mL	15.3196 mL
	15 mM	0.4085 mL	2.0426 mL	4.0852 mL	10.2130 mL
	20 mM	0.3064 mL	1.5320 mL	3.0639 mL	7.6598 mL
	25 mM	0.2451 mL	1.2256 mL	2.4511 mL	6.1278 mL
	30 mM	0.2043 mL	1.0213 mL	2.0426 mL	5.1065 mL
	40 mM	0.1532 mL	0.7660 mL	1.5320 mL	3.8299 mL
	50 mM	0.1226 mL	0.6128 mL	1.2256 mL	3.0639 mL
	60 mM	0.1021 mL	0.5107 mL	1.0213 mL	2.5533 mL
	80 mM	0.0766 mL	0.3830 mL	0.7660 mL	1.9149 mL
	100 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.5320 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.