1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    Drug-Linker Conjugates for ADC

McMMAF (Synonyms: Maleimidocaproyl monomethylauristatin F)

Cat. No.: HY-15578 Purity: 99.47%
Handling Instructions

Mc-MMAF is a protective group-conjugated MMAF.

For research use only. We do not sell to patients.

McMMAF Chemical Structure

McMMAF Chemical Structure

CAS No. : 863971-19-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1832 In-stock
Estimated Time of Arrival: December 31
1 mg USD 660 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1176 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Mc-MMAF is a protective group-conjugated MMAF. MMAF is a more potent drug than Monomethyl auristatin E (MMAE), but is charged and relatively membrane-impermeable, is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Target: MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0809 mL 5.4045 mL 10.8089 mL
5 mM 0.2162 mL 1.0809 mL 2.1618 mL
10 mM 0.1081 mL 0.5404 mL 1.0809 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    McMMAF is dissolved in DMSO and then diluted with 0.9% NaCl[2].

Molecular Weight







O=C([[email protected]](C)[[email protected]]([[email protected]]1([H])CCCN1C(C[[email protected]@H](OC)[[email protected]@]([H])(N(C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C)C(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C)[[email protected]@H](C)CC)=O)OC)N[[email protected]](C(O)=O)CC3=CC=CC=C3


4°C, stored under nitrogen


Room temperature in continental US; may vary elsewhere

Purity: 99.47%

  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Cat. No.: HY-15578