1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
  2. Drug-Linker Conjugates for ADC
  3. McMMAF

McMMAF (Synonyms: Maleimidocaproyl monomethylauristatin F)

Cat. No.: HY-15578 Purity: 99.58%
Handling Instructions

McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.

For research use only. We do not sell to patients.

McMMAF Chemical Structure

McMMAF Chemical Structure

CAS No. : 863971-19-1

Size Price Stock Quantity
1 mg USD 500 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.

IC50 & Target



In Vitro

MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





O=C([[email protected]](C)[[email protected]]([[email protected]]1([H])CCCN1C(C[[email protected]@H](OC)[[email protected]@]([H])(N(C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C)C(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C)[[email protected]@H](C)CC)=O)OC)N[[email protected]](C(O)=O)CC3=CC=CC=C3


Room temperature in continental US; may vary elsewhere.


-20°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (108.09 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0809 mL 5.4045 mL 10.8089 mL
5 mM 0.2162 mL 1.0809 mL 2.1618 mL
10 mM 0.1081 mL 0.5404 mL 1.0809 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (5.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (5.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  1% DMSO    99% saline

    Solubility: ≥ 0.5 mg/mL (0.54 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 99.58%

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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


McMMAFMaleimidocaproyl monomethylauristatin FDrug-Linker Conjugates for ADCMicrotubule/TubulinInhibitorinhibitorinhibit

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