1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    Drug-Linker Conjugates for ADC

McMMAF (Synonyms: Maleimidocaproyl monomethylauristatin F)

Cat. No.: HY-15578 Purity: >99.0%
Data Sheet SDS Handling Instructions

Mc-MMAF is a protective group-conjugated MMAF.

For research use only. We do not sell to patients.
McMMAF Chemical Structure

McMMAF Chemical Structure

CAS No. : 863971-19-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1832 In-stock
1 mg USD 660 In-stock
5 mg USD 1176 In-stock
10 mg USD 1800 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Mc-MMAF is a protective group-conjugated MMAF. MMAF is a more potent drug than Monomethyl auristatin E (MMAE), but is charged and relatively membrane-impermeable, is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. Target: MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.0809 mL 5.4045 mL 10.8089 mL
5 mM 0.2162 mL 1.0809 mL 2.1618 mL
10 mM 0.1081 mL 0.5404 mL 1.0809 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

925.16

Formula

C₄₉H₇₆N₆O₁₁

CAS No.

863971-19-1

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

McMMAF is dissolved in DMSO and then diluted with 0.9% NaCl[2].

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

References

Purity: >99.0%

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Product Name:
McMMAF
Cat. No.:
HY-15578
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