1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. JPM-OEt

JPM-OEt 

Cat. No.: HY-102087
Handling Instructions

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity.

For research use only. We do not sell to patients.

JPM-OEt Chemical Structure

JPM-OEt Chemical Structure

CAS No. : 262381-84-0

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Description

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2].

In Vivo

JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly[1].
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis[2].
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment[3].

Animal Model: Female mice of a transgenic mouse[3]
Dosage: 50 mg/kg
Administration: i.p.; daily from 63 to 98 days
Result: Caused a significant delay in the increase of tumour burden during the first 2 weeks of treatment. However, on days 84, 91 and 98 no significant differences between both groups could be detected.
Molecular Weight

392.45

Formula

C₂₀H₂₈N₂O₆

CAS No.

262381-84-0

SMILES

O=C([[email protected]]1O[[email protected]@H]1C(N[[email protected]](C(NCCC2=CC=C(O)C=C2)=O)CC(C)C)=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JPM-OEtCathepsintumorcathepsinBactivitybreastcancermetastasisregressionInhibitorinhibitorinhibit

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JPM-OEt
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