1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. JPM-OEt

JPM-OEt 

Cat. No.: HY-102087 Purity: 98.61%
Handling Instructions

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity.

For research use only. We do not sell to patients.

JPM-OEt Chemical Structure

JPM-OEt Chemical Structure

CAS No. : 262381-84-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 638 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 638 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2].

In Vivo

JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly[1].
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis[2].
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mice of a transgenic mouse[3]
Dosage: 50 mg/kg
Administration: i.p.; daily from 63 to 98 days
Result: Caused a significant delay in the increase of tumour burden during the first 2 weeks of treatment. However, on days 84, 91 and 98 no significant differences between both groups could be detected.
Molecular Weight

392.45

Formula

C₂₀H₂₈N₂O₆

CAS No.
SMILES

O=C([[email protected]]1O[[email protected]@H]1C(N[[email protected]](C(NCCC2=CC=C(O)C=C2)=O)CC(C)C)=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (318.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5481 mL 12.7405 mL 25.4810 mL
5 mM 0.5096 mL 2.5481 mL 5.0962 mL
10 mM 0.2548 mL 1.2740 mL 2.5481 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (15.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (15.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (15.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

JPM-OEtCathepsintumorcathepsinBactivitybreastcancermetastasisregressionInhibitorinhibitorinhibit

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Product Name:
JPM-OEt
Cat. No.:
HY-102087
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