1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. IA-Alkyne

IA-Alkyne (Synonyms: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide)

Cat. No.: HY-136205
Handling Instructions

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling.

For research use only. We do not sell to patients.

IA-Alkyne Chemical Structure

IA-Alkyne Chemical Structure

CAS No. : 930800-38-7

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Description

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2].

IC50 & Target

IC50: TRPC[1]

In Vitro

IA-alkyne (2.5-10 μM; 1 hour) can react with cysteines. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag through CuAAC, and analyzed by SDS-PAGE. In-gel fluorescence imaging reveals that IA-alkyne has a strong fluorescent intensity[2].

Molecular Weight

265.09

Formula

C₈H₁₂INO

CAS No.

930800-38-7

SMILES

O=C(NCCCCC#C)CI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IA-AlkyneIodoacetamide-alkyneN-Hex-5-ynyl-2-iodo-acetamideTRP ChannelTransient receptor potential channelsasthmachronic bronchitisemphysemachronicobstructivecystic fibrosisbronchiectasisFluorescencegelimagingcysteineInhibitorinhibitorinhibit

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