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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Bacterial membrane

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (221) Acetyl-CoA Carboxylase (1) Acyltransferase (1) Akt (4) AMPK (1) Antibiotic (25) Apoptosis (14) ASCT (1) Autophagy (4) Bcl-2 Family (2) Biochemical Assay Reagents (8) Carnitine Palmitoyltransferase (CPT) (1) Caspase (3) CDK (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (6) Drug Derivative (2) Endogenous Metabolite (10) Environmental Pollutants (7) ERK (4) Estrogen Receptor/ERR (6) Farnesyl Transferase (2) Fatty Acid Synthase (FASN) (1) FGFR (1) Fluorescent Dye (10) Formyl Peptide Receptor (FPR) (2) Fungal (15) GLUT (1) Glutathione Peroxidase (6) Glycosidase (1) HIV (1) HSV (1) Interleukin Related (6) Isotope-Labeled Compounds (9) JNK (3) Lactate Dehydrogenase (1) Mitochondrial Metabolism (5) MMP (1) mTOR (2) Na+/K+ ATPase (2) NADH Dehydrogenase (1) Necroptosis (2) NF-κB (4) Nuclear Factor of activated T Cells (NFAT) (1) P-glycoprotein (1) p38 MAPK (2) Parasite (8) PARP (1) PDI (1) Penicillin-binding protein (PBP) (1) Phosphatase (6) Photosensitizer (1) PI3K (4) PKA (1) Potassium Channel (1) PPAR (1) Ras (2) Reactive Oxygen Species (ROS) (38) Reference Standards (9) SARS-CoV (6) Sodium Channel (2) Squalene Monooxygenase (1) TNF Receptor (3) Toll-like Receptor (TLR) (3) Topoisomerase (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (11) Endocrinology (1) Infection (223) Inflammation/Immunology (33) Metabolic Disease (9) Neurological Disease (15)
Oligonucleotides:	Phospholipids (1)

244

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Bacterial PSMA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17362

Vancomycin hydrochloride Maximum Cited Publications 94 Publications Verification	Bacterial Autophagy Antibiotic	Infection Cancer
Vancomycin hydrochloride is an antibiotic for the treatment of *bacterial* infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

HY-W012669

Phthalaldehyde Phthaldialdehyde	Environmental Pollutants Biochemical Assay Reagents	Infection
Phthalaldehyde (Phthaldialdehyde) reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Antibiotic PDI	Infection
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N8332

Bile extract Ox bile extract	Bacterial DNA/RNA Synthesis	Infection
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .

HY-B1597

Cetalkonium chloride Benzyldimethylhexadecylammonium chloride	Bacterial	Infection Inflammation/Immunology
Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death .

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection Cancer
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-P0311

LAH4	Bacterial	Infection
LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-N1136

(+)-Totarol	Bacterial	Infection
(+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections .

HY-P5255

Oligopeptide-10	Bacterial	Infection Inflammation/Immunology
Oligopeptide-10 is a bioactive peptide with antimicrobial activity. Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive *bacteria* including Propionibacterium acnes and Staphylococcus aureus. Oligopeptide-10 targets lipoteichoic acid (LTA) on the surface of bacterial cell membranes, induces bacterial osmotic imbalance by disrupting the integrity of bacterial membranes, and reduces the release of pro-inflammatory cytokines induced by bacteria. Oligopeptide-10 possesses skin-protective activity. Oligopeptide-10 can be applied in research related to acne vulgaris, dandruff, seborrheic dermatitis, and tinea pedis .

HY-127032

Polyquaternium-1 Polidronium chloride	Biochemical Assay Reagents	Infection
Polyquaternium-1 (Polidronium chloride; PQ-1) is an antimicrobial preservative and an activator of NF-κB. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001% and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops (Travoprost preparations containing PQ-1), artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride (HY-B2232) .

HY-156004

Ziapin 2	Bacterial	Others
Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the *bacterial* plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties .

HY-P10233A

SAAP 148 TFA	Bacterial	Infection
SAAP 148 TFA is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 TFA kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 TFA retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 TFA can be used in infection-related research .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-121219

(-)-Lupinine	Bacterial	Infection
(-)-Lupinine is an alkaloid and membrane fusion inhibitor. (-)-Lupinine does not affect the synthesis of proinflammatory cytokines during the host response to Serratia proteamaculans infection. (-)-Lupinine can enhance the expression of the bacterial surface protein OmpX. (-)-Lupinine can be used for research on bacterial infections .

HY-W008884

25-NBD Cholesterol	Bacterial	Others
25-NBD Cholesterol is a fluorescently labeled form of cholesterol that facilitates the distinction between exogenous and endogenous cholesterol within bacterial cell membranes, emitting green fluorescence signals.

HY-P0311A

LAH4 TFA	Bacterial	Infection
LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-P3328A

MDP1 acetate	Bacterial	Infection
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .

HY-P11430

UBI (31-38)	Biochemical Assay Reagents	Infection
UBI (31-38) is a Ubiquicidin-derived octapeptide and anti-bacterial agent. UBI (31-38) selectively interacts with anionic phospholipid membranes and restricts lipid lateral motion. UBI (31-38) induces anionic vesicle aggregation via electrostatic repulsion screening, and undergoes conformational changes in membrane-mimicking environments. UBI (31-38) can be used for the research of infection imaging probes .

HY-103658

Myramistin Miramistin	Bacterial	Infection
Myramistin (Miramistin) is an antibacterial agent targeting *bacterial* cell membrane. Myramistin can bind to the negatively charged surface of bacteria through its cationic properties, disrupt the integrity of the bacterial cell membrane, inhibit bacterial metabolism and growth, and induce cell death, thus exerting antibacterial activity .

HY-149734

MA220607	Bacterial	Infection
MA220607 is a FtsZ protein inhibitor with activity against both Gram-positive and Gram-negative bacteria. MA220607 inhibits bacterial growth and shows low bacterial resistance frequency. MA220607 increases bacterial membrane permeability and alters proton gradients. MA220607 blocks the formation of bacterial biofilms. MA220607 can be used in studies of bacterial infections .

HY-P10233

SAAP 148	Bacterial	Infection
SAAP 148 is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 can be used in infection-related research .

HY-P10696

C16G2	Bacterial	Infection
C16G2 is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. C16G2 exhibits higher selectivity and efficacy against Streptococcus mutans, unlike broad-spectrum antimicrobial peptides .

HY-143643

Antibacterial agent 72	Bacterial	Infection
Antibacterial agent 72 displays the antibacterial activities by targeting the **bacterial membrane**.

HY-P10519

Brevicidine	Bacterial Reactive Oxygen Species (ROS)	Infection
Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics .

HY-P10980

Citrocin	DNA/RNA Synthesis Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

HY-P11442

Lytx-Pa2a Lycotoxin-Pa2a; TBIU041425	Bacterial Toll-like Receptor (TLR)	Inflammation/Immunology
Lytx-Pa2a (Lycotoxin-Pa2a) is a peptide inhibitor against **bacterial membranes and TLR4 receptor*. Lytx-Pa2a exerts antimicrobial effects via non-competitive disruption of outer/cytoplasmic membranes* and suppression of LPS-induced TLR4/NF-κB signaling. Lytx-Pa2a is promising for research of bacterial infection and inflammation-related disease (e.g., sepsis) .

HY-178952

Anti-infective agent 12	Bacterial	Infection
Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC₅₀ of 4.475 μM and a K_d of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models .

HY-W154333

H-Arg-OtBu dihydrochloride	Bacterial	Infection
H-Arg-OtBu (dihydrochloride) is a membrane-targeting antimicrobial. H-Arg-OtBu (dihydrochloride) targets the negatively charged *bacterial* membrane via a combination of electrostatic and hydrophobic interactions. H-Arg-OtBu (dihydrochloride) can be used for bacterial infections diseases research .

HY-179396

T-1228	Bacterial	Infection
T-1228 is a highly selective LpxC inhibitor. T-1228 can effectively block the synthesis of LPS (HY-D1056), causing defects in the bacterial outer membrane structure, increasing membrane permeability, and ultimately leading to bacterial cell death. T-1228 can be used for the study of Gram-negative bacterial infections .

HY-P10907

Zaloganan	Bacterial	Infection
Zaloganan exhibits board-spectrum antibacterial activity through disruption of bacterial membranes .

HY-175301

TH16	Bacterial Reactive Oxygen Species (ROS)	Infection
TH16 is an antibacterial agent (MIC=2 μg/mL against methicillin-resistant Staphylococcus aureus, MRSA). TH16 disrupts bacterial cytoplasmic membrane integrity, elevating intracellular reactive oxygen species (ROS) levels to induce bacterial death. TH16 is promising for research of bacterial infection .

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-P10696A

C16G2 TFA	Bacterial	Infection
C16G2 TFA is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 TFA specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. C16G2 TFA exhibits higher selectivity and efficacy against Streptococcus mutans, unlike broad-spectrum antimicrobial peptides .

HY-170991

C12-rrw-NH2	Bacterial Reactive Oxygen Species (ROS)	Infection
C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides .

HY-158881

DDG	Biochemical Assay Reagents	Inflammation/Immunology
DDG is a type of detergent that can dissolve membrane proteins (MPs) in bacterial membranes, insect cells, and Madin Darby Canine Kidney (MDCK) cells .

HY-144823

Anti-MRSA agent 3	Bacterial	Infection
Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against *Methicillin-resistant Staphylococcus aureus* (MRSA) with MIC** of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA .

HY-161689

Antibacterial agent 220	Bacterial	Infection
Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains .

HY-144822

Anti-MRSA agent 2	Bacterial	Infection
Anti-MRSA agent 2 (compound 14) has highly inhibitory activity against *Methicillin-resistant Staphylococcus aureus* (MRSA) with MIC** of 0.098 μg/ml, and relatively low cytotoxicity in normal cells. Anti-MRSA agent 2 has strong ability to destroy bacterial membrane and bind to genomic DNA .

HY-P5680

SpHistin	Bacterial	Inflammation/Immunology
SpHistin is an antimicrobial peptide (AMP). SpHistin can bind to LPS (HY-D1056) and permeabilize the bacterial membrane. SpHistin combined with Rifampicin (HY-B0272) and Azithromycin (HY-17506) promotes the intracellular uptake of the antibiotics and subsequently enhances the bactericidal activity of both agents against P. aeruginosa .

HY-162672

Antibacterial agent 231	Bacterial	Infection
Antibacterial agent 231 (derivative 8) is an antimicrobial agent against multidrug-resistant Helicobacter pylori (H. pylori) with a minimum inhibitory concentration of 0.25–0.5 μg/mL. Antibacterial agent 231 directly targets the protein transposase subunit SecA and the outer membrane protein assembly factor BamD to inhibit the trafficking and assembly of bacterial outer membrane proteins (OMPs). Antibacterial agent 231 can be used to study the effects of antibiotic treatment on intestinal microbial balance .

HY-168881

Antibacterial agent 262	Bacterial	Infection
Antibacterial agent 262 (compound A23) is a potent antibacterial agent. Antibacterial agent 262 inhibits Xanthomonas oryzae pv oryzae activity. Antibacterial agent 262 inhibits the formation of Xanthomonas oryzae pv oryzae biofilms, disrupting the integrity of bacterial cell membranes .

HY-161364

Antibacterial agent 200	Bacterial	Inflammation/Immunology
Antibacterial agent 200 (pyridyl HH 7), a unique hydrazyl hydroxycoumarin (HH), has strong antibacterial efficacy and broad antibacterial spectrum with MIC values ranging from 0.5 to 32 μg/mL for Gram-positive and Gram-negative bacteria. Antibacterial agent 200 exhibits a good inhibition against Pseudomonas aeruginosa 27853 with a low MIC value of 0.5 μg/mL. Antibacterial agent 200 can eradicate the integrity of bacterial membrane, result in the leakage of intracellular proteins, and interact with bacterial DNA gyrase via non-covalent binding .

HY-147546

Antibacterial agent 107	Bacterial	Infection
Antibacterial agent 107 (compound 14) is a potent antibacterial agent. Antibacterial agent 107 shows potent antibacterial activity against Gram-positive bacteria, with a MIC of 1.56 μg/mL (MRSA). Antibacterial agent 107 exhibits low hemolytic activity, high membrane selectivity, and rapid bactericidal activity. Antibacterial agent 107 shows effective in vivo efficacy in the murine model of bacterial keratitis caused by Staphylococcus aureus ATCC29213 .

HY-P11220

Hs02	Bacterial Interleukin Related	Infection
Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 μM, and the MBC is 2-4 μM. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research .

HY-168204

3-Acetyl-28-N-(3-guanidinobutoxy)-oleanolic acid	Bacterial Fungal	Infection
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .

HY-P10970

RT2	Bacterial	Infection
RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide, with main targets including lipopolysaccharide (LPS) on the bacterial surface and intracellular DNA. RT2 binds to bacterial surface LPS, and interacts with cytoplasmic membrane phospholipids, enabling it to rapidly penetrate the bacterial cell membrane and enter the cell, and then bind to components such as DNA in the cytoplasmic membrane, thereby exerting antibacterial effects. RT2 is promising for research of acute and chronic infections caused by planktonic bacteria .

HY-P991273

MP196	Antibiotic Bacterial	Infection
MP196 is a cationic hexapeptide antibiotic targeting the bacterial cytoplasmic membrane, which exerts rapid bactericidal activity by disrupting membrane integrity, inhibiting cell respiration and cell wall synthesis. MP196 is promising for research of drug-resistant bacterial infections .

HY-174158

Antibacterial agent 270	Bacterial	Infection
Antibacterial agent 270 (Compound 3e) is an antibacterial agent that acts on bacterial membrane components phosphatidylglycerol (PG), cardiolipin (CL), and bacterial DNA. Antibacterial agent 270 disrupts bacterial membrane structure and binds to DNA to interfere with genetic information transmission. Antibacterial agent 270 is promising for research of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) .

Cat. No.	Product Name

HY-L067

Antibiotics Library

752 compounds

Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents.

MCE supplies a unique collection of 752 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.

Cat. No.	Product Name	Type

HY-111391

Resazurin sodium

5 Publications Verification

Diazoresorcinol sodium

Fluorescent Dyes

Resazurin sodium (Diazoresorcinol sodium) is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-D2908

SYTO9

Fluorescent Dyes

SYTO9 is a green fluorescent nucleic acid dye (Ex = 485 nm, Em = 498 nm (DNA)/501 nm (RNA)). SYTO9 can penetrate the intact cell membrane of viable bacteria. When the cell membrane is damaged (cell death), its rate of entry into cells increases, and it competes with propidium iodide (PI) (HY-D0815), another membrane-impermeable dye, for nucleic acid binding sites. SYTO9 is widely used in fluorescence microscopy, flow cytometry, and fluorometric assays in microbiology for bacterial counting, viability assessment, and cell imaging .

HY-D2919

DMN-Tre

Fluorescent Dyes

DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .

HY-118540

Resazurin

Diazoresorcinol

Fluorescent Dyes

Resazurin (Diazoresorcinol) is a water-soluble, non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-DY1051

Resazurin sodium (solution)

Fluorescent Dyes

Resazurin sodium (Diazoresorcinol sodium) (solution) is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .
Solvent and Concentration: Sterile water: 10 mM

HY-D2986

TBD–anchor	Fluorescent Dyes
TBD–anchor is a water-soluble, positively charged AIE photosensitizer. TBD–anchor can specifically bind to *bacterial* membranes and efficiently produce ¹O₂. TBD–anchor has bactericidal activity against various bacteria and good biocompatibility. TBD–anchor can be used for research on bacterial infections .

HY-D1737

RADA

Fluorescent Dyes

RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

Cat. No.	Product Name	Type

HY-111391A

Resazurin sodium, indicator

Diazoresorcinol sodium, indicator

Biochemical Assay Reagents

Resazurin (Diazoresorcinol) sodium, indicator is a non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin sodium, indicator is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin sodium, indicator can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-W012669

Phthalaldehyde

Phthaldialdehyde

Biochemical Assay Reagents

Phthalaldehyde (Phthaldialdehyde) reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria .

HY-N8332

Bile extract Ox bile extract	Biochemical Assay Reagents
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .

HY-W015551

trans-2-Decenal

(E)-Dec-2-enal

Biochemical Assay Reagents

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-141633

Sucrose monolaurate

Biochemical Assay Reagents

Sucrose monolaurate is a glycolipid surfactant . Sucrose monolaurate interacts with bacterial DNA, disrupts cell membrane permeability, and exerts excellent inhibitory and bactericidal effects against a variety of foodborne pathogens (especially Gram-positive bacteria). Sucrose monolaurate significantly reduces liquid surface tension, and acts as a synergist for chlorine-based disinfectants in food cleaning and disinfection to improve the removal efficiency of pathogens on the surface of agricultural products .

HY-W250308A

ε-Poly-L-lysine hydrochloride (MV 2000-5000)

Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)

Biochemical Assay Reagents

ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections .

HY-158082B

TRITC-dextran, MW 40000

Tetramethyl rhodamine isothiocyanate glucan, MW 40000

Biochemical Assay Reagents

TRITC-dextran (Tetramethyl rhodamine isothiocyanate glucan), MW 40000 is a TRITC (HY-D0791)-labeled neutral 40 kDa fluorescent polysaccharide probe. TRITC-dextran, MW 40000 forms a membrane layer on the surface of protocells composed of protamine/folate condensates, and is used to assess membrane fluidity via fluorescence recovery after photobleaching. TRITC-dextran, MW 40000 can also be used to evaluate the anti-bacterial invasion ability and colloidal stability of coated condensates, as well as analyze the permeability of vascular and lymphatic endothelial cell layers .

HY-W016473

Adamantane-carboxylic acid

Biochemical Assay Reagents

Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

HY-W015551R

trans-2-Decenal (Standard)

(E)-Dec-2-enal (Standard)

Biochemical Assay Reagents

trans-2-Decenal ((E)-Dec-2-enal)) Standard is the analytical standard of trans-2-Decenal (HY-W015551). This product is intended for research and analytical applications. trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

Cat. No.	Product Name	Target	Research Area

HY-17362

Vancomycin hydrochloride Maximum Cited Publications 94 Publications Verification	Bacterial Autophagy Antibiotic	Infection Cancer
Vancomycin hydrochloride is an antibiotic for the treatment of *bacterial* infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

HY-P4744

LL-37 amide 2 Publications Verification	Formyl Peptide Receptor (FPR) Bacterial	Infection Cancer
LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection Cancer
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-P0311

LAH4	Bacterial	Infection
LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P5255

Oligopeptide-10	Bacterial	Infection Inflammation/Immunology
Oligopeptide-10 is a bioactive peptide with antimicrobial activity. Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive *bacteria* including Propionibacterium acnes and Staphylococcus aureus. Oligopeptide-10 targets lipoteichoic acid (LTA) on the surface of bacterial cell membranes, induces bacterial osmotic imbalance by disrupting the integrity of bacterial membranes, and reduces the release of pro-inflammatory cytokines induced by bacteria. Oligopeptide-10 possesses skin-protective activity. Oligopeptide-10 can be applied in research related to acne vulgaris, dandruff, seborrheic dermatitis, and tinea pedis .

HY-P2460

SMAP-29	Bacterial Fungal Interleukin Related TNF Receptor	Infection Inflammation/Immunology
SMAP‑29 is a cathelicidin antimicrobial peptide with LPS‑binding and anti‑inflammatory properties. SMAP‑29 exerts broad‑spectrum antimicrobial activity against *bacteria, fungi* and multidrug‑resistant isolates. SMAP‑29 kills pathogens by permeabilizing bacterial membranes, inducing depolarization and cell lysis, and also inhibits inflammatory cytokines while reducing lethality in septic shock and pneumonia models. SMAP-29 can be used for research on bacterial infections, drug-resistant infections, septic shock .

HY-P1116

PBP10 1 Publications Verification	Bacterial Reactive Oxygen Species (ROS) Interleukin Related	Infection Inflammation/Immunology
PBP10 is a decapeptide. PBP10 selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP₂). PBP10 penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis .

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P10233A

SAAP 148 TFA	Bacterial	Infection
SAAP 148 TFA is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 TFA kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 TFA retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 TFA can be used in infection-related research .

HY-A0248B

Polymyxin B2	Antibiotic Bacterial	Infection
Polymyxin B2 is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 can be used in antibiotic development and treatment of drug-resistant strains .

HY-P4809

Polybia-MP1	Bacterial Fungal	Infection Cancer
Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers .

HY-P5557

TP4 (Nile tilapia piscidin)	Bacterial Necroptosis	Infection Inflammation/Immunology
TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields .

HY-P0311A

LAH4 TFA	Bacterial	Infection
LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .

HY-P4744A

LL-37 amide TFA 2 Publications Verification	Formyl Peptide Receptor (FPR) Bacterial	Infection Cancer
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .

HY-P3328A

MDP1 acetate	Bacterial	Infection
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P5203

Enterocin K1 EntK1	Bacterial	Infection
Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets *Enterococcus faecalis* via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .

HY-P10281

RW3	Bacterial	Infection Cardiovascular Disease
RW3 (MP196) is a small cationic antimicrobial hexapeptide. RW3 targets the bacterial cytoplasmic membrane and inhibits cellular respiration and cell wall synthesis. RW3 exhibits high bioactivity against Gram-positive bacteria such as Bacillus subtilis 168 (MIC of 2 µg/mL). RW3 causes shrinking of murine erythrocytes. RW3 can be used in antimicrobial and antifungal research .

HY-P2302

Defensin HNP-3 human	Antibiotic Bacterial Fungal	Infection Inflammation/Immunology Cancer
Defensin HNP-3 human is an α-defensin stored in the azurophilic granules of human neutrophils. Defensin HNP-3 human exerts broad-spectrum bactericidal, antifungal and antiviral activities mainly by forming bacterial membrane pores, and acts as a chemoattractant for monocytes and T cells. Defensin HNP-3 human maintains epithelial integrity to support periodontal tissue homeostasis, and exerts concentration-dependent effects on epithelial cell proliferation, adhesion and bacterial adhesion. Defensin HNP-3 human targets solid tumors and leukemia by inducing single-strand DNA breaks and membrane permeabilization in tumor cells via electrostatic binding and pore formation. Defensin HNP-3 human is abundant in human tongue squamous cell carcinoma and neutrophils infiltrating oral squamous cell carcinoma. Defensin HNP-3 human can be applied to research related to periodontitis and human tongue squamous cell carcinoma .

HY-P1116A

PBP10 TFA 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
PBP10 TFA is a decapeptide. PBP10 TFA selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP₂). PBP10 TFA penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 TFA is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis .

HY-P11430

UBI (31-38)	Biochemical Assay Reagents	Infection
UBI (31-38) is a Ubiquicidin-derived octapeptide and anti-bacterial agent. UBI (31-38) selectively interacts with anionic phospholipid membranes and restricts lipid lateral motion. UBI (31-38) induces anionic vesicle aggregation via electrostatic repulsion screening, and undergoes conformational changes in membrane-mimicking environments. UBI (31-38) can be used for the research of infection imaging probes .

HY-P10233

SAAP 148	Bacterial	Infection
SAAP 148 is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 can be used in infection-related research .

HY-P10696

C16G2	Bacterial	Infection
C16G2 is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. C16G2 exhibits higher selectivity and efficacy against Streptococcus mutans, unlike broad-spectrum antimicrobial peptides .

HY-P5641

Pleurocidin 1 Publications Verification	Bacterial p38 MAPK NF-κB NADH Dehydrogenase Antibiotic	Infection Inflammation/Immunology
Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections .

HY-P5057A

5-FAM-LL-37 TFA	Fluorescent Dye Bacterial	Infection
5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .

HY-P5640

Tritrpticin	Bacterial Parasite	Infection
Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against Trichomonas vaginalis, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia .

HY-P10519

Brevicidine	Bacterial Reactive Oxygen Species (ROS)	Infection
Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics .

HY-P10980

Citrocin	DNA/RNA Synthesis Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

HY-P11074

Sakacin P	Bacterial	Infection
Sakacin P is an antimicrobial peptide that targets Gram-positive bacteria (such as Listeria monocytogenes) and belongs to Class IIa bacteriocin. Sakacin P has almost no antimicrobial activity against Gram-negative bacteria. Sakacin P exerts its antimicrobial activity by interacting with bacterial cell membranes and destroying membrane integrity. Sakacin P can be used for the study of Listeria contamination and antimicrobial drugs in the food industry.

HY-P11165

DRGN-1	Bacterial	Infection
DRGN-1 is an antimicrobial peptide. DRGN-1 exhibits potent antimicrobial and anti-biofilm activities, inhibiting both Gram-negative and Gram-positive bacteria, with an EC₅₀ range of 0.50-4.62 μM. DRGN-1 exerts its antimicrobial effect by disrupting bacterial membrane permeability and slightly depolarizing the membrane potential. DRGN-1 inhibits the formation of biofilms of single bacterial species and mixed species of Pseudomonas aeruginosa and Staphylococcus aureus. DRGN-1 can significantly promote the healing of uninfected and mixed biofilm-infected mouse wounds. DRGN-1 can be used for the study of infections .

HY-W012572A

D-Histidine hydrochloride hydrate	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-P11442

Lytx-Pa2a Lycotoxin-Pa2a; TBIU041425	Bacterial Toll-like Receptor (TLR)	Inflammation/Immunology
Lytx-Pa2a (Lycotoxin-Pa2a) is a peptide inhibitor against **bacterial membranes and TLR4 receptor*. Lytx-Pa2a exerts antimicrobial effects via non-competitive disruption of outer/cytoplasmic membranes* and suppression of LPS-induced TLR4/NF-κB signaling. Lytx-Pa2a is promising for research of bacterial infection and inflammation-related disease (e.g., sepsis) .

HY-P10907

Zaloganan	Bacterial	Infection
Zaloganan exhibits board-spectrum antibacterial activity through disruption of bacterial membranes .

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-P10696A

C16G2 TFA	Bacterial	Infection
C16G2 TFA is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 TFA specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. C16G2 TFA exhibits higher selectivity and efficacy against Streptococcus mutans, unlike broad-spectrum antimicrobial peptides .

HY-105048A

Omiganan pentahydrochloride	Bacterial	Infection
Omiganan pentahydrochloride is a cationic peptide compound with a broad antibacterial profile. Omiganan pentahydrochloride is capable of inhibiting a variety of bacteria, including yeast, and is active against both gram-positive and gram-negative bacteria. Omiganan pentahydrochloride is able to interact with the bacterial cell membrane, causing the destruction of the cell membrane and the death of the bacteria. Omiganan pentahydrochloride can be used for the study of antimicrobial activity against pathogens commonly associated with catheter-associated infections, including strains with drug-resistant phenotypes .

HY-P10556

(KFF)3K	Bacterial	Infection
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P5680

SpHistin	Bacterial	Inflammation/Immunology
SpHistin is an antimicrobial peptide (AMP). SpHistin can bind to LPS (HY-D1056) and permeabilize the bacterial membrane. SpHistin combined with Rifampicin (HY-B0272) and Azithromycin (HY-17506) promotes the intracellular uptake of the antibiotics and subsequently enhances the bactericidal activity of both agents against P. aeruginosa .

HY-P11220

Hs02	Bacterial Interleukin Related	Infection
Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 μM, and the MBC is 2-4 μM. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research .

HY-P10970

RT2	Bacterial	Infection
RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide, with main targets including lipopolysaccharide (LPS) on the bacterial surface and intracellular DNA. RT2 binds to bacterial surface LPS, and interacts with cytoplasmic membrane phospholipids, enabling it to rapidly penetrate the bacterial cell membrane and enter the cell, and then bind to components such as DNA in the cytoplasmic membrane, thereby exerting antibacterial effects. RT2 is promising for research of acute and chronic infections caused by planktonic bacteria .

HY-P10682

PuroA	Bacterial	Infection
PuroA is a tryptophan-rich domain of Puroindoline a that exerts antibacterial activity through interaction with bacterial membranes .

HY-P5932

Maculatin 1.1 TFA	Bacterial	Infection
Maculatin 1.1 TFA is an antimicrobial peptide with an MIC against Staphylococcus aureus of 7 μM. Maculatin 1.1 TFA can perforate the bacterial membrane of Staphylococcus aureus, causing bacterial death .

HY-P5949

AMPR-22	Bacterial	Infection
AMPR-22 is an antimicrobial peptide. AMPR-22 can bind to the bacterial membrane and induces membrane permeabilization. AMPR-22 is effective against murine model of sepsis induced by MDR strains

HY-P10362

Temporin-GHd	Bacterial	Infection
Temporin-GHd exhibits antibacterial activity against Streptococcus mutans (MIC=13.1 μM; MBC=26 μM). Temporin-GHd increases the permeability of the bacterial cell membrane, causing membrane damage and leakage of cellular contents. Temporin-GHd disrupts preformed biofilms at high concentrations. Temporin-GHd can bind to bacterial DNA, inhibiting DNA migration .

HY-P11251

RI-18	Bacterial	Infection
RI-18 is an antimicrobial peptide. RI-18 exhibits high affinity for bacterial plasma membranes, inducing rapid membrane permeabilization and rupture. RI-18 exhibits potent antimicrobial activity against bacteria in planktonic and biofilmforms .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991273

MP196	Antibiotic Bacterial	Infection
MP196 is a cationic hexapeptide antibiotic targeting the bacterial cytoplasmic membrane, which exerts rapid bactericidal activity by disrupting membrane integrity, inhibiting cell respiration and cell wall synthesis. MP196 is promising for research of drug-resistant bacterial infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17362

Vancomycin hydrochloride Maximum Cited Publications 94 Publications Verification	Plant Cell Culture Microorganisms Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Bacterial Autophagy Antibiotic
Vancomycin hydrochloride is an antibiotic for the treatment of *bacterial* infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

HY-N0570

Hydroxytyrosol 5+ Cited Publications DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol	Infection Structural Classification Canarium album (Lour.) Rauesch. Classification of Application Fields Phenols Polyphenols Plants Endogenous metabolite Burseraceae Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR
Hydroxytyrosol (DOPET; 3,4-Dihydroxyphenethyl alcohol) is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and *bacterial* translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-129555

Surfactin 5+ Cited Publications	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Bacterial HSV Antibiotic
Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .

HY-B1228

Ribostamycin sulfate 1 Publications Verification Vistamycin sulfate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic PDI
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant K_D of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections .

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-135416

Streptolysin O 2 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-I1070

D-Isoleucine (R)-Isoleucine	Microorganisms Source Classification	ASCT
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].

HY-W015551

trans-2-Decenal (E)-Dec-2-enal	Structural Classification Natural Products Vaccinium vitis-idaea L. Ericaceae Plants Source Classification	Bacterial Reactive Oxygen Species (ROS)
trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-105088

Pexiganan MSI 78 free base	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-P0270

Magainin 2 Magainin II	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Antibiotic Fungal
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-N9459

2-Amino-2-deoxyglucose hydrochloride D-Glucosamine Hydrochloride	Structural Classification Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	GLUT
2-Amino-2-deoxyglucose hydrochloride (D-Glucosamine Hydrochloride) is a glucose analog that is specifically recognized and transported by the cell membrane GLUT1. 2-Amino-2-deoxyglucose hydrochloride acts as a tumor-targeting ligand and a guiding molecule for the synthesis of prodrug conjugates, thus delivering drugs precisely to tumor cells. 2-Amino-2-deoxyglucose hydrochloride is applicable to diagnostic imaging and therapeutic efficacy monitoring of solid tumors and various cancers (e.g., breast cancer, glioblastoma). 2-Amino-2-deoxyglucose hydrochloride also helps bacteria resist lysozyme digestion by integrating into the non-N-acetylated residues of Streptococcus pneumoniae peptidoglycan. 2-Amino-2-deoxyglucose hydrochloride is used in studies on tumor metabolism and the exploration of bacterial drug resistance mechanisms .

HY-N1136

(+)-Totarol	Infection Animals Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Source Classification	Bacterial
(+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections .

HY-N6043

Hydroxytyrosol acetate	Structural Classification Canarium album (Lour.) Rauesch. Classification of Application Fields Phenols Polyphenols Plants Burseraceae Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV Estrogen Receptor/ERR
Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-N5112A

β,β-Dimethylacrylalkannin 3 Publications Verification Arnebin 1	Quinones Structural Classification other families Classification of Application Fields Other Diseases Plants Naphthalene Quinones Pteris livida Mett. Disease Research Fields	FGFR Necroptosis Apoptosis CDK JNK
β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC₅₀=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .

HY-17362R

Vancomycin hydrochloride (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Phenols Polyphenols Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Autophagy Antibiotic
Vancomycin (hydrochloride) (Standard) is the analytical standard of Vancomycin (hydrochloride). This product is intended for research and analytical applications. Vancomycin hydrochloride is an antibiotic for the treatment of *bacterial* infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

HY-W012572

D-Histidine	Microorganisms Source Classification	Mitochondrial Metabolism Bacterial
D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-135416A

Streptolysin O (≥1000000 units/mg) 1 Publications Verification	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Other Diseases Alismataceae Plants Disease Research Fields Source Classification	AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy
Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis .

HY-N0570R

Hydroxytyrosol (Standard) DOPET (Standard); 3,4-Dihydroxyphenethyl alcohol (Standard); 3-Hydroxytyrosol (Standard)	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Endogenous metabolite Burseraceae Source Classification	Reference Standards Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR
Hydroxytyrosol (Standard) (DOPET (Standard)) is the analytical standard of Hydroxytyrosol (HY-N0570). This product is intended for research and analytical applications. Hydroxytyrosol is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N11546

Sapindoside B	Structural Classification Eleutherococcus sieboldianus Makino Terpenoids Diterpenoids Plants Araliaceae Source Classification	Cytochrome P450 Bacterial Fungal
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases *bacterial* adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-105088A

Pexiganan acetate MSI 78	Structural Classification Natural Products Animals Source Classification	Bacterial
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-108191

Paldimycin A Antibiotic 273a1α	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Fields Source Classification	Bacterial Antibiotic
Paldimycin A (Antibiotic 273a1α) is an antibiotic derived from Streptomyces paulus, primarily targeting Gram-positive bacteria. Paldimycin A exerts its antibacterial effects by interfering with bacterial protein synthesis and cell membrane function .

HY-N7188

CJ-21,058	Natural Products Microorganisms Source Classification	Bacterial
CJ-21,058 is a potent SecA inhibitor with an IC₅₀ value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .

HY-W012572R

D-Histidine (Standard)	Microorganisms Source Classification	Reference Standards Mitochondrial Metabolism Bacterial
D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-161935

6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid	Lysimachia tengyuehensis Hand.-Mazz. Antibiotics Plants Primulaceae Other Antibiotics Source Classification	Bacterial
6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid (Compound 2) exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin enterococci (VRE). 6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid interfers with the integrity and function of the bacterial cell membrane, and affects metabolism in MRSA. 6-(12-Tridecene-1-yl)-2,4-Dihydroxy benzoic acid exhibits anti-inflammatory and anti-infective efficacy, and promotes angiogenesis in mice .

HY-W015551R

trans-2-Decenal (Standard) (E)-Dec-2-enal (Standard)	Structural Classification Natural Products Vaccinium vitis-idaea L. Ericaceae Plants Source Classification	Biochemical Assay Reagents Reference Standards
trans-2-Decenal ((E)-Dec-2-enal)) Standard is the analytical standard of trans-2-Decenal (HY-W015551). This product is intended for research and analytical applications. trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici.

HY-N6043R

Hydroxytyrosol acetate (Standard)	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Reference Standards Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR
Hydroxytyrosol acetate (Standard) is the analytical standard of Hydroxytyrosol (HY-N0570). This product is intended for research and analytical applications. Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-N18435

Komaroidine	Structural Classification Alkaloids Nitraria schoberi L. Nitrariaceae Plants Indole Alkaloids Source Classification	Bacterial Reactive Oxygen Species (ROS)
Komaroidine is a bactericidal agent. Komaroidine induces reactive oxygen species (ROS) bursts in bacterial cells, disrupts antioxidant enzyme function and redox homeostasis, increases membrane permeability, and triggers bacterial apoptosis. Komaroidine suppresses bacterial burden within infected plant tissues.Komaroidine exhibits broad-spectrum antibacterial activity against phytopathogenic bacteria including Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Pseudomonas syringae pv. actinidiae. Komaroidine can be used for the research of rice bacterial leaf blight .

HY-N10342

Cajanol	Structural Classification Flavonoids Leguminosae Phenols Polyphenols Plants Isoflavones Cajanus cajan (L.) Millsp. Source Classification	Apoptosis Bcl-2 Family Caspase PARP Reactive Oxygen Species (ROS) Bacterial PI3K Akt NF-κB P-glycoprotein
Cajanol is an isoflavanone that can be isolated from the roots of Cajanus cajan (L.) Millsp. . Cajanol inhibits cancer cell proliferation and induces cancer cell apoptosis. Cajanol promotes the expression of Bax, inhibits the expression of Bcl-2, activates caspase-9 and caspase-3, induces PARP cleavage, arrests the cell cycle at the G2/M phase, generates ROS, disrupts mitochondrial membrane potential and triggers cytochrome c release. Cajanol induces *bacterial* DNA damage, disrupts bacterial cell membranes, and exerts antibacterial activity in vitro. Cajanol reduces the expression of PI3K, inhibits the phosphorylation of Akt and NF-κB, downregulates the expression and transport function of P-gp, restores the sensitivity of drug-resistant cancer cells to Paclitaxel, and inhibits the growth of Paclitaxel-resistant metastatic ovarian tumors. Cajanol is applicable to research related to breast cancer, ovarian cancer and bacterial infections .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-180427

Viscosin	Structural Classification Microorganisms Cyclopeptides Source Classification	Bacterial Endogenous Metabolite
Viscosin is a cyclic lipopeptide compound produced by the Pseudomonas genus. Viscosin exerts its antibacterial effect through two mechanisms: membrane permeabilization and interference with cell wall synthesis. Viscosin shows significant antibacterial activity against various Gram-positive bacteria, but has no inhibitory effect on fungi. Viscosin can be used for the study of bacterial infections .

HY-N19782

Striatisporolide A	Athyriaceae Structural Classification Ketones, Aldehydes, Acids Athyrium multidentatum (Döll) Ching Plants Source Classification	Bacterial Apoptosis Reactive Oxygen Species (ROS)
Striatisporolide A is an antibacterial agent. Striatisporolide A exhibits antibacterial activity against Escherichia coli in vitro. Striatisporolide A damages the cell wall and cell membrane of Escherichia coli, and induces changes in protein levels and morphology. Striatisporolide A reduces the level of apoptosis (apoptosis) in HUVECs, inhibits excessive production of ROS, and possesses pro-proliferative and mild cytoprotective effects. Striatisporolide A can be used in studies related to *bacterial* infections and degenerative diseases .

HY-N16699

4'-O-Methyl-8-prenylnaringenin	Structural Classification Flavonoids Animals Flavonones Source Classification	Bacterial
4'-O-Methyl-8-prenylnaringenin is a prenylated flavonoid compound with antibacterial activity, which can be isolated from propolis of the Solomon Islands. 4'-O-Methyl-8-prenylnaringenin exerts its antibacterial activity by enhancing cell penetration and damaging bacterial cell membranes or cell walls. The minimum inhibitory concentrations (MICs) against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa are 32 μg/mL, 32 μg/mL, and 128 μg/mL, respectively .

HY-N16448

Xanthoascin	Monophenols Microorganisms Phenols Source Classification	Bacterial
Xanthoascin (Compound 1) is a natural phenolic metabolite with strong anti plant pathogen activity. Xanthoascin can be extracted from the solid fermentation product of endophytic fungus Aspergillus sp. IFB-YXS isolated from Ginkgo biloba leaves. Xanthoascin has a MIC of 0.3125 µg/mL against Clavibacter michiganense subsp. Sepedonicus and moderate inhibitory activity against other pathogens (MIC = 5-20 µg/mL). Xanthoascin can disrupt the permeability of bacterial cell membranes, leading to nucleic acid leakage .

Cat. No.	Product Name	Chemical Structure

HY-B0671S

Vancomycin-d12 TFA
Vancomycin-d₁₂ TFA is a deuterium labeled Vancomycin (HY-B0671). Vancomycin is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis .

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N0570S

Hydroxytyrosol-d4

Hydroxytyrosol-d₄ (DOPET-d₄) is the deuterium labeled Hydroxytyrosol (HY-N0570). Hydroxytyrosol is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-N0570S1

Hydroxytyrosol-d5

Hydroxytyrosol-d₅ (DOPET-d5) is the deuterium labeled Hydroxytyrosol (HY-N0570). Hydroxytyrosol is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .

HY-W774926

Permethrin-d6

Permethrin-d₆ (NRDC-143-d₆) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) .

HY-W015551S

trans-2-Decenal-d2

trans-2-Decenal-d₂ ((E)-Dec-2-enal-d₂) is deuterated labeled trans-2-Decenal (HY-W015551). trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-W724344

Cetalkonium-d5 chloride

Cetalkonium-d₅ chloride (Benzyldimethylhexadecylammonium-d₅ chloride) is the deuterium labeled Cetalkonium chloride (HY-B1597). Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death .

HY-W012669S

Phthalaldehyde-d4

Phthalaldehyde-d₄ (Phthaldialdehyde-d₄) is the deuterium labeled Phthalaldehyde (HY-W012669). Phthalaldehyde reacts with proteins containing primary amines and blocked amino-terminal peptides of amino acids. Phthalaldehyde stabilizes bacterial outer membranes and cell walls, increases the optical density of bacterial cell suspensions, and inhibits bacterial lysis induced by ethylenediaminetetraacetic acid and sodium dodecyl sulfate. Phthalaldehyde exhibits bactericidal activity against Gram-negative vegetative bacteria.

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name		Classification

HY-157618

18:0-18:1 PG sodium		Phospholipids
18:0-18:1 PG sodium is a hydrogenated phospholipid that contributes to the stability of photosystem I and II protein complexes and plays a role in bacterial defense mechanisms, featuring two extra methylene groups in its saturated sn-1 chain, and is present in the thylakoid membranes of higher plants and cyanobacteria.

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