Antibacterial agent 341
Antibacterial agent 341 is an anti-bacterial agent. Antibacterial agent 341 shows broad-spectrum Gram-positive antibacterial activity. Antibacterial agent 341 targets phosphatidylglycerol (PG) and cardiolipin (CL) in bacterial cell membranes, induces sustained depolarization of membranes, and disrupts the cell membrane integrity. Antibacterial agent 341 exhibits anti-infection activity against S. aureus-induced subcutaneous abscesses in mice.
For research use only. We do not sell to patients.
- CAS No.: 3023862-30-5
- Formula: C38H56N2O4
- Molecular Weight:604.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 341 (Compound I-9)(two-fold serial dilutions; 16-18 h) exhibits Gram-positive-selective antibacterial activity, potently inhibiting S. aureus with an MIC of 2 μg/mL and demonstrating broad-spectrum activity against clinically relevant Gram-positive pathogens[1].
Antibacterial agent 341 (1 h) has extremely low hemolytic toxicity against sheep red blood cells, with an HC50 >1280 μg/mL[1].
Antibacterial agent 341 (8 μg/mL; 8 h) rapidly kills S. aureus, eliminating all detectable bacteria within 2 h[1].
Antibacterial agent 341 (8-32 μg/mL; 22 min) induces rapid, sustained depolarization of S. aureus cell membrane, confirming its membrane-targeted mechanism of action[1].
Antibacterial agent 341 (16 μg/mL; 2 h) induces significant nucleic acid leakage from S. aureus cells, indicating potent membrane-disrupting activity[1].
Antibacterial agent 341 (8-16 μg/mL; 20 min) disrupts the cell membrane integrity of S. aureus, allowing PI to enter and label bacterial nucleic acids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus
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Concentration:8, 16 μg/mL
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Incubation Time:20 min
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Result:Increased intracellular PI fluorescence intensity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice with Staphylococcus aureus infection (female, 6-8 weeks old, 29-33 g, subcutaneous abscess model)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:s.c.; single injection
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Result:Reduced bacterial survival rate in skin lesions to 0.485% at 5 mg/kg.
Reduced bacterial survival rate in skin lesions to 0.156% at 10 mg/kg.
Showed superior efficacy to 5 mg/kg vancomycin (HY-B0671) (bacterial survival rate 2.559%) at 5 mg/kg.
Markedly alleviated abscess symptoms, with only mild abscess formation observed at both doses.
Chemical Information
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CAS No. 3023862-30-5
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Molecular Weight 604.86
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Formula C38H56N2O4
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SMILES
O=C(C1=CC=C(OCCCCCCCCCCOC2=CC=C(C(CCN3CCCCC3)=O)C=C2)C=C1)CCN4CCCCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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