2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 341

Antibacterial agent 341 is an anti-bacterial agent. Antibacterial agent 341 shows broad-spectrum Gram-positive antibacterial activity. Antibacterial agent 341 targets phosphatidylglycerol (PG) and cardiolipin (CL) in bacterial cell membranes, induces sustained depolarization of membranes, and disrupts the cell membrane integrity. Antibacterial agent 341 exhibits anti-infection activity against S. aureus-induced subcutaneous abscesses in mice.

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Antibacterial agent 341

Antibacterial agent 341 Chemical Structure

CAS No. : 3023862-30-5

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Antibacterial agent 341 Related Antibodies

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Description

Antibacterial agent 341 is an anti-bacterial agent. Antibacterial agent 341 shows broad-spectrum Gram-positive antibacterial activity. Antibacterial agent 341 targets phosphatidylglycerol (PG) and cardiolipin (CL) in bacterial cell membranes, induces sustained depolarization of membranes, and disrupts the cell membrane integrity. Antibacterial agent 341 exhibits anti-infection activity against S. aureus-induced subcutaneous abscesses in mice[1].

In Vitro

Antibacterial agent 341 (Compound I-9)(two-fold serial dilutions; 16-18 h) exhibits Gram-positive-selective antibacterial activity, potently inhibiting S. aureus with an MIC of 2 μg/mL and demonstrating broad-spectrum activity against clinically relevant Gram-positive pathogens[1].
Antibacterial agent 341 (1 h) has extremely low hemolytic toxicity against sheep red blood cells, with an HC50 >1280 μg/mL[1].
Antibacterial agent 341 (8 μg/mL; 8 h) rapidly kills S. aureus, eliminating all detectable bacteria within 2 h[1].
Antibacterial agent 341 (8-32 μg/mL; 22 min) induces rapid, sustained depolarization of S. aureus cell membrane, confirming its membrane-targeted mechanism of action[1].
Antibacterial agent 341 (16 μg/mL; 2 h) induces significant nucleic acid leakage from S. aureus cells, indicating potent membrane-disrupting activity[1].
Antibacterial agent 341 (8-16 μg/mL; 20 min) disrupts the cell membrane integrity of S. aureus, allowing PI to enter and label bacterial nucleic acids[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 341 Related Antibodies

Immunofluorescence[1]

Cell Line: S. aureus
Concentration: 8, 16 μg/mL
Incubation Time: 20 min
Result: Increased intracellular PI fluorescence intensity.
In Vivo

Antibacterial agent 341 (Compound I-9) (5-10 mg/kg; s.c.; single injection) exhibits potent inhibitory efficacy against S. aureus-induced subcutaneous abscesses in mice, with 10 mg/kg reducing bacterial survival to 0.156%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice with Staphylococcus aureus infection (female, 6-8 weeks old, 29-33 g, subcutaneous abscess model)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: s.c.; single injection
Result: Reduced bacterial survival rate in skin lesions to 0.485% at 5 mg/kg.
Reduced bacterial survival rate in skin lesions to 0.156% at 10 mg/kg.
Showed superior efficacy to 5 mg/kg vancomycin (HY-B0671) (bacterial survival rate 2.559%) at 5 mg/kg.
Markedly alleviated abscess symptoms, with only mild abscess formation observed at both doses.
Molecular Weight

604.86

Formula

C38H56N2O4
CAS No.
SMILES

O=C(C1=CC=C(OCCCCCCCCCCOC2=CC=C(C(CCN3CCCCC3)=O)C=C2)C=C1)CCN4CCCCC4
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Room temperature in continental US; may vary elsewhere.
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References
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Antibacterial agent 341 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 3413023862-30-5Antibacterial agent341Antibacterial agent-341Bacterialphosphatidylglycerolcell membrane integrityred blood cellsGram-positive pathogensbacterial cell membranessubcutaneous abscessnucleic acid leakagecardiolipinS. aureusInhibitorinhibitorinhibit

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