1. Anti-infection
  2. Bacterial
  3. SPR206 acetate

SPR206 acetate 

Cat. No.: HY-128780B
Handling Instructions

SPR206 acetate, a polymyxin analogue, and shows antibiotic activity against multidrug resistant Gram-negative pathogen. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L.

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SPR206 acetate Chemical Structure

SPR206 acetate Chemical Structure

CAS No. : 2408422-41-1

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Description

SPR206 acetate, a polymyxin analogue, and shows antibiotic activity against multidrug resistant Gram-negative pathogen. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L[1][2].

IC50 & Target

MIC: 0.125 mg/L (Pseudomonas aeruginosa Pa14) and 0.125 mg/L (Acinetobacter baumannii NCTC13301[1][2]

In Vitro

SPR206 exhibits strong anti-microbial properties against Gram-negative bacteria. The MIC values of SPR206 against E. coli IHMA558090, E. coli ATCC 25922, K. pneumonia ATCC 13882, P. aeruginosa ATCC 27853, A. baumannii NCTC13424 and A. baumannii ATCC 19003 are 8 mg/L, 0.125 mg/L, 0.125 mg/L, 0.25 mg/L, 0.06 mg/L and 0.125 mg/L, respectively, together with lower cytotoxicity [1].

In Vivo

SPR206 (0.125-30 mg/kg; intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours; neutropenic mice) treatment reduces the burden of Pa14 and NCTC13301 in lung tissue and in the thigh model[2].

Animal Model: Neutropenic mice infected Pa14 or NCTC13301[2]
Dosage: 3 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg (intravenous injection); 0.125 mg/kg, 0.5 mg/kg, 1 mg/kg, 4 mg/kg (subcutaneous injection)
Administration: Intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours
Result: In lung tissue, reduced the burden of Pa14 and NCTC13301 by 1.5 and 3.6 log10 CFU/mL. In the thigh model, reduced the burden of Ab13301 by 3.4 and 4.3 log10 CFU/g.
Formula

C₅₂H₈₂ClN₁₅O₁₂.xC₂H₄O₂

CAS No.

2408422-41-1

SMILES

O=C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCN)C(N[[email protected]@H](CCN)C(N1)=O)=O)=O)[[email protected]](NC([[email protected]](CCN)NC([[email protected]](CCNC([[email protected]@H]1[[email protected]](O)C)=O)NC([[email protected]](CN)NC([[email protected]@H](NC(C[[email protected]@H](C2=CC=CC(Cl)=C2)CN)=O)[[email protected]](O)C)=O)=O)=O)=O)CC3=CC=CC=C3.CC(O)=O.[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

SPR206SPR 206SPR-206BacterialGram-negativepolymyxinantibioticInhibitorinhibitorinhibit

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