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Cat. No.: HY-P11583

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N2W2

N2W2 is a tryptophan- and lysine-rich β-hairpin antimicrobial peptide. N2W2 exhibits potent antimicrobial activity but also high toxicity. N2W2 is highly susceptible to trypsin or chymotrypsin. N2W2 can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

Formula: C₉₀H₁₁₁N₂₁O₁₀
Molecular Weight:1646.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N2W2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

N2W2 (2-256 μM; 18 h) exhibits potent antimicrobial activity against S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, K. pneumoniae ATCC 700603, E. coli ATCC 25922, and P. aeruginosa ATCC 27853 with a geometric mean of the MIC of 6.3 μM^[1].
N2W2 (16-2048 μM; 1 h) exhibits high hemolytic activity against Kunming mouse blood cells with an MHC of 70.8 μM^[1].
N2W2 (1 h) exhibits significant cytotoxicity against NRK-52E and GES-1 cells with CC₅₀ values of 10.1 μM and 4.3 μM, respectively^[1].
N2W2 is highly susceptible to trypsin or
chymotrypsin and nearly lost their antimicrobial activity after incubation with trypsin or chymotrypsin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1646.98
Formula C₉₀H₁₁₁N₂₁O₁₀
Sequence

Trp-Lys-Trp-Lys-Trp-Trp-Lys-Trp-Lys-Trp-NH2
Sequence Shortening

WKWKWWKWKW-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li B, et al. Leucine/Isoleucine Substitution Scanning of Tryptophan Residues to Reduce the Toxicity of β-Hairpin Peptide N2W2. J Med Chem. 2025;68(13):13772-13792. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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