1. Anti-infection
  2. Bacterial
  3. Antibacterial agent 139

Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane.

For research use only. We do not sell to patients.

Antibacterial agent 139 Chemical Structure

Antibacterial agent 139 Chemical Structure

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Description

Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane[1].

In Vitro

Antibacterial agent 139 (Compound 44) (18 h) inhibits the growth of biofilm-forming S. aureus and S. epidermidis strains, with MIC values less than 12.5 μg/mL[1].
Antibacterial agent 139 (24 h) shows citotoxicity against lung and skin fibroblast cell lines (MCR-5 and BJ), with IC50s of 12.5 and >25 μg/mL[1].
Antibacterial agent 139 (60 min) is metabolically stable in rat liver microsomes, displaying a low Clearance value (8.94 μL/min/mg)[1].
Antibacterial agent 139 depolarizes the bacterial cell membrane[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MSSA, MSSE, SP, MRSA, VISA, LRSE
Concentration: 0-12.5 μg/mL
Incubation Time: 18 h
Result: MIC values : 3.125, 3.125, 6.25, 0.78, 3.125, 3.125 μg/mL respectively.
Molecular Weight

532.00

Formula

C28H29ClF3N3O2

SMILES

O=C(NC1CCN(CC1)CCC(C2=CC=CC=C2)OC3=CC=CC(C(F)(F)F)=C3)NC4=CC=CC(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antibacterial agent 139 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antibacterial agent 139
Cat. No.:
HY-149095
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