MDP1
MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa.
For research use only. We do not sell to patients.
- Formula: C111H202N34O28
- Molecular Weight:2461.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MDP1 exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa. Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL). Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2461.00
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Formula C111H202N34O28
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Sequence Shortening
GIGAVLKVLTTGLPALIKRKRQQ
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDP1 Related Classifications
HY-P3328 Related Classifications
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