1. Anti-infection
  2. Bacterial
  3. MDP1

MDP1 

Cat. No.: HY-P3328
Handling Instructions

MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MDP1 Chemical Structure

MDP1 Chemical Structure

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Description

MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1].

In Vitro

MDP1 exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa. Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL). Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2461.00

Formula

C₁₁₁H₂₀₂N₃₄O₂₈

Sequence Shortening

GIGAVLKVLTTGLPALIKRKRQQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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MDP1
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