2-Amino-2-deoxyglucose hydrochloride
Based on 1 Customer Validation
2-Amino-2-deoxyglucose hydrochloride (D-Glucosamine Hydrochloride) is a glucose analog that is specifically recognized and transported by the cell membrane GLUT1. 2-Amino-2-deoxyglucose hydrochloride acts as a tumor-targeting ligand and a guiding molecule for the synthesis of prodrug conjugates, thus delivering drugs precisely to tumor cells. 2-Amino-2-deoxyglucose hydrochloride is applicable to diagnostic imaging and therapeutic efficacy monitoring of solid tumors and various cancers (e.g., breast cancer, glioblastoma). 2-Amino-2-deoxyglucose hydrochloride also helps bacteria resist lysozyme digestion by integrating into the non-N-acetylated residues of Streptococcus pneumoniae peptidoglycan. 2-Amino-2-deoxyglucose hydrochloride is used in studies on tumor metabolism and the exploration of bacterial drug resistance mechanisms.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1078691-95-8
- Formula: C6H14ClNO5
- Molecular Weight:215.63
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GLUT1 |
2-Amino-2-deoxyglucose hydrochloride (25-50 mM; 30 min) significantly inhibits GLUT1-mediated cellular uptake of 2DG-SUC-ADM and 2DG-ICG-Der-01 in HepG2 cells[1].
2-Amino-2-deoxyglucose hydrochloride does not reduce the viability of MDA-MB-231, HepG2, MCF-7, MCF-7/ADR cancer cells or HELF normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:25 mM, 50 mM
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Incubation Time:30 min
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Result:Significantly inhibits GLUT1-mediated cellular uptake of 2DG-SUC-ADM and 2DG-ICG-Der-01 in HepG2 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice; Kunming mice (Charles River Laboratories)[1]
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Dosage:50 mg/kg
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Administration:i.v.; single dose
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Result:Reduced the tumor/normal tissue ratio of 2DG-ICG-Der-01 from 3.8 to 1.72.
Chemical Information
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CAS No. 1078691-95-8
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Appearance Solid
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Molecular Weight 215.63
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Formula C6H14ClNO5
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Color White to off-white
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SMILES
OC1[C@H](N)[C@H]([C@@H]([C@@H](CO)O1)O)O.[H]Cl
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Synonyms
D-Glucosamine Hydrochloride
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Structure Classification
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Initial Source
Vibrio
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (463.76 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (463.76 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6376 mL | 23.1879 mL | 46.3757 mL | 115.9393 mL |
| 5 mM | 0.9275 mL | 4.6376 mL | 9.2751 mL | 23.1879 mL | |
| 10 mM | 0.4638 mL | 2.3188 mL | 4.6376 mL | 11.5939 mL | |
| 15 mM | 0.3092 mL | 1.5459 mL | 3.0917 mL | 7.7293 mL | |
| 20 mM | 0.2319 mL | 1.1594 mL | 2.3188 mL | 5.7970 mL | |
| 25 mM | 0.1855 mL | 0.9275 mL | 1.8550 mL | 4.6376 mL | |
| 30 mM | 0.1546 mL | 0.7729 mL | 1.5459 mL | 3.8646 mL | |
| 40 mM | 0.1159 mL | 0.5797 mL | 1.1594 mL | 2.8985 mL | |
| 50 mM | 0.0928 mL | 0.4638 mL | 0.9275 mL | 2.3188 mL | |
| 60 mM | 0.0773 mL | 0.3865 mL | 0.7729 mL | 1.9323 mL | |
| 80 mM | 0.0580 mL | 0.2898 mL | 0.5797 mL | 1.4492 mL | |
| 100 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1594 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Amino-2-deoxyglucose hydrochloride Related Classifications
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