1078691-95-8
Chemical Structure
2-Amino-2-deoxyglucose hydrochloride
Synonym(s): D-Glucosamine Hydrochloride
- CAS No.: 1078691-95-8
- Formula:C6H14ClNO5
- Molecular Weight:215.63
IUPAC Name: (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol hydrochloride
InChIKey: QKPLRMLTKYXDST-NSEZLWDYSA-N
SMILES: OC1[C@H](N)[C@H]([C@@H]([C@@H](CO)O1)O)O.[H]Cl
Biological Activity:
2-Amino-2-deoxyglucose hydrochloride (D-Glucosamine Hydrochloride) is a glucose analog that is specifically recognized and transported by the cell membrane GLUT1. 2-Amino-2-deoxyglucose hydrochloride acts as a tumor-targeting ligand and a guiding molecule for the synthesis of prodrug conjugates, thus delivering drugs precisely to tumor cells. 2-Amino-2-deoxyglucose hydrochloride is applicable to diagnostic imaging and therapeutic efficacy monitoring of solid tumors and various cancers (e.g., breast cancer, glioblastoma). 2-Amino-2-deoxyglucose hydrochloride also helps bacteria resist lysozyme digestion by integrating into the non-N-acetylated residues of Streptococcus pneumoniae peptidoglycan. 2-Amino-2-deoxyglucose hydrochloride is used in studies on tumor metabolism and the exploration of bacterial drug resistance mechanisms[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Amino-2-deoxyglucose hydrochloride | 98.0% | 2-Amino-2-deoxyglucose hydrochloride (D-Glucosamine Hydrochloride) is a glucose analog that is specifically recognized and transported by the cell membrane GLUT1. 2-Amino-2-deoxyglucose hydrochloride acts as a tumor-targeting ligand and a guiding molecule for the synthesis of prodrug conjugates, thus delivering drugs precisely to tumor cells. 2-Amino-2-deoxyglucose hydrochloride is applicable to diagnostic imaging and therapeutic efficacy monitoring of solid tumors and various cancers (e.g., breast cancer, glioblastoma). 2-Amino-2-deoxyglucose hydrochloride also helps bacteria resist lysozyme digestion by integrating into the non-N-acetylated residues of Streptococcus pneumoniae peptidoglycan. 2-Amino-2-deoxyglucose hydrochloride is used in studies on tumor metabolism and the exploration of bacterial drug resistance mechanisms. |
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2-Amino-2-deoxyglucose hydrochloride (Standard) | ≥98% | 2-Amino-2-deoxyglucose (hydrochloride) (Standard) is (D-Glucosamine Hydrochloride (Standard)) the analytical standard of 2-Amino-2-deoxyglucose (hydrochloride) (HY-N9459). This product is intended for research and analytical applications. 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc. | ||||||||||||||||||||
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2-Amino-2-deoxyglucose hydrochloride-13C2 | 2-Amino-2-deoxyglucose hydrochloride-13C2 (D-Glucosamine Hydrochloride-1,2-13C2) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc. | |||||||||||||||||||||
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2-Amino-2-deoxyglucose hydrochloride-13C6 | 2-Amino-2-deoxyglucose hydrochloride-13C6 (D-Glucosamine Hydrochloride-13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc. | |||||||||||||||||||||
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References
- [1]. Cao J, et al. Targeted cancer therapy with a 2-deoxyglucose-based adriamycin complex. Cancer Res. 2013;73(4):1362-1373. [Content Brief]
- [2]. Ohno N, Yadomae T, Miyazaki T. Identification of 2-amino-2-deoxyglucose residues in the peptidoglucan of Streptococcus pneumoniae[J]. Carbohydrate research, 1982, 107(1): 152-155.
