Sucrose monolaurate

Sucrose monolaurate (1.25-80 mM; 24 h) exhibits potent antibacterial activity against Gram-positive L. monocytogenes (MIC = 2.5 mM, MBC = 20 mM), B. subtilis (MIC = 2.5 mM, MBC = 20 mM), and S. aureus (MIC = 10 mM, MBC = 40 mM), with weak activity against Gram-negative E. coli (MIC = 40 mM)^[1].
Sucrose monolaurate (1-4× MIC; 0-48 h) exerts rapid concentration-dependent bactericidal activity against Gram-positive L. monocytogenes, B. subtilis, and S. aureus, with complete viability loss within 2-4 h at 1× MIC, while E. coli shows only partial, transient inhibition at 1× MIC^[1].
Sucrose monolaurate (1× MIC; 20 h) causes severe morphological damage, including pore formation and cell collapse, in Gram-positive L. monocytogenes, B. subtilis, and S. aureus, but only minor surface changes in Gram-negative E. coli^[1].
Sucrose monolaurate (10 mM; 1 h) induces membrane depolarization (less negative zeta potential) in L. monocytogenes and E. coli, with a more pronounced and distinct effect on Gram-positive L. monocytogenes^[1].
Sucrose monolaurate (5-10 mM; 10 min) interacts with L. monocytogenes genomic DNA to alter its structure and conformation, but does not cause significant DNA damage^[1].
Sucrose monolaurate (1/8-1/2 MIC; 48 h) potently inhibits biofilm formation by L. monocytogenes, B. subtilis, and E. coli, but stimulates biofilm formation by S. aureus^[1].
Sucrose monolaurate (100-10,000 ppm; 3 min) alone removes Escherichia coli O157:H7 from inoculated baby spinach leaves in a concentration-dependent manner, achieving a maximum reduction of ~1.9 log CFU/leaf at 10,000 ppm and 4 °C, and ~1.6 log CFU/leaf at 10,000 ppm and 20 °C^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.