Lug-15 

Lug-15 is a rapid bactericidal agent. Lug-15 exhibits strong antibacterial activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. Lug-15 rapidly kills bacteria primarily through membrane disruption and had a very low propensity to induce bacterial resistance. Lug-15 demonstrates low hemolytic toxicity and significant therapeutic potential in various infection models. Lug-15 can be used for research on combating infections caused by multi-drug resistant bacteria^[1].

Lug-15 exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria tested with MICs of 3.13 μg/mL (S. aureus and Methicillin-resistant S. aureus (MRSA)), 6.25 μg/mL (E. gallinarum) and 12.5 μg/mL (P. aeruginosa, baumannii and E. coli)^[1].
Lug-15 (2 × MIC, 0-12 h) reduces the S. aureus and E. coli count from 10^5.5 CFU/mL to 0 within 4 hours^[1].
Lug-15 (× MIC, 0.5-1 h) disrupted the integrity of the bacterial outer membrane/membrane of S. aureus and E. coli and damaged the inner membrane of E. coli, causing irreversible damage to the cell membrane^[1].
Lug-15 (0.5-4 × MIC, 4 h) significantly reduces the ATP content within bacterial cells and causes a concentration-dependent significant increase in ROS levels in S. aureus^[1].
Lug-15 (0.5 MIC, passaged for 21 times) is extremely difficult to induce S. aureus to develop resistance^[1].
Lug-15 (6.25-200 μg/mL, 1 h) exhibits the hemolysis rate in rat red blood cells was below 10% at the effective antibacterial concentration^[1].
Lug-15 (0-48 h) has good stability in mammalian serum and can maintain its antibacterial activity in complex physiological environments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lug-15 (1 mg/mL, eye drops, multiple times) is effective in treating MRSA or P. aeruginosa infections in the eyes in mice^[1].
Lug-15 (5-15 mg/kg, i.p. or local use of hydrogel, single dose or 2-4 doses) demonstrates strong efficacy in models of MRSA infections in the thigh, lungs, and wounds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1120.42

C₅₆H₈₁N₁₇O₆S

O=C(N[C@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]1CCCNC(N)=N)=O)=O)[C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H]2CSC([C@H](C(C)C)NC1=O)N2)=O)=O)CC(C3=C4C=CC=C3)=CN4CC5=CC=C(C6=CC=CC=C6)C=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. He Y, et al. Expanding the antimicrobial spectrum of lugdunin: Discovery of multi-cationic derivatives of lugdunin with antimicrobial activity against gram-positive and gram-negative bacteria. Eur J Med Chem. 2025 Dec 5;299:118078.  [Content Brief]