Lug-15
Lug-15 is a rapid bactericidal agent. Lug-15 exhibits strong antibacterial activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. Lug-15 rapidly kills bacteria primarily through membrane disruption and had a very low propensity to induce bacterial resistance. Lug-15 demonstrates low hemolytic toxicity and significant therapeutic potential in various infection models. Lug-15 can be used for research on combating infections caused by multi-drug resistant bacteria.
For research use only. We do not sell to patients.
- Formula: C56H81N17O6S
- Molecular Weight:1120.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Lug-15 exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria tested with MICs of 3.13 μg/mL (S. aureus and Methicillin-resistant S. aureus (MRSA)), 6.25 μg/mL (E. gallinarum) and 12.5 μg/mL (P. aeruginosa, baumannii and E. coli)[1].
Lug-15 (2 × MIC, 0-12 h) reduces the S. aureus and E. coli count from 10^5.5 CFU/mL to 0 within 4 hours[1].
Lug-15 (× MIC, 0.5-1 h) disrupted the integrity of the bacterial outer membrane/membrane of S. aureus and E. coli and damaged the inner membrane of E. coli, causing irreversible damage to the cell membrane[1].
Lug-15 (0.5-4 × MIC, 4 h) significantly reduces the ATP content within bacterial cells and causes a concentration-dependent significant increase in ROS levels in S. aureus[1].
Lug-15 (0.5 MIC, passaged for 21 times) is extremely difficult to induce S. aureus to develop resistance[1].
Lug-15 (6.25-200 μg/mL, 1 h) exhibits the hemolysis rate in rat red blood cells was below 10% at the effective antibacterial concentration[1].
Lug-15 (0-48 h) has good stability in mammalian serum and can maintain its antibacterial activity in complex physiological environments[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lug-15 (5-15 mg/kg, i.p. or local use of hydrogel, single dose or 2-4 doses) demonstrates strong efficacy in models of MRSA infections in the thigh, lungs, and wounds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Keratitis Model infected with MRSA or P. aeruginosa established in six-week-old female Kunming mice (weighing 20-22 g)[1]
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Dosage:1 mg/mL
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Administration:Eye drops, multiple times
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Result:Reduced the bacterial load in the eyes, and the appearance of the eyeball becomed clearer.
Significantly reduced the infiltration of inflammatory cells.
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Animal Model:Neutropenic thigh infection model and pneumonia model established in six-week-old female Kunming mice (weighing 20-22 g)[1]
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Dosage:15 (Neutropenic thigh infection) and 5 mg/kg (pneumonia infection)
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Administration:Intraperitoneal injection (i.p.), 4 doses (Neutropenic thigh infection) and 2 doses (pneumonia infection)
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Result:Significantly inhibited the spread of infection, and the bacterial load in the thigh tissue was significantly reduced.
Reduced pulmonary congestion and the bacterial load in the lungs, and lowered the levels of inflammatory factors and pathological damage.
Chemical Information
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Molecular Weight 1120.42
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Formula C56H81N17O6S
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SMILES
O=C(N[C@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]1CCCNC(N)=N)=O)=O)[C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H]2CSC([C@H](C(C)C)NC1=O)N2)=O)=O)CC(C3=C4C=CC=C3)=CN4CC5=CC=C(C6=CC=CC=C6)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lug-15 Related Classifications
HY-178504 Related Classifications
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