Antibacterial agent 220
Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains.
For research use only. We do not sell to patients.
- Formula: C37H54N8O8S
- Molecular Weight:770.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
| L929 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
Antibacterial agent 220 (compound 43), which has a longer hydrophobic chain, exhibited potent antibacterial activity against both Gram-positive bacteria (MICs of 0.78-1.56 μg/mL) and Gram-negative bacteria (MIC of 6.25 μg/mL) and poor hemolytic activity (HC50 > 200 μg/mL). Antibacterial agent 220 shows MIC values of 1.56 μg/mL, 0.78 μg/mL, 0.78 μg/mL, and 6.25 μg/mL for S. aureus ATCC29213, MRSA N315, MRSA NCTC10442, and E. coli ATCC25922, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks old mice (C57BL6) bearing bacterial cells (S. aureus ATCC29213)[1]
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Dosage:0.5%
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Administration:Applied topically to the infected murine corneas; four times, with an interval of about 2 h; for three consecutive days
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Result:Exhibited a strong in vivo antibacterial efficacy.
Chemical Information
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Molecular Weight 770.94
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Formula C37H54N8O8S
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SMILES
O=S(C1=CC=C(OC/C=C(CC/C=C(C)/C)/C)C=C1)(C2=CC=C(OCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(OC)=O)CCCNC(N)=N)=O)=O)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 220 Related Classifications
HY-161689 Related Classifications
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