Antibacterial agent 220
Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C37H54N8O8S
- Molecular Weight:770.94
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
| L929 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
In Vitro
Antibacterial agent 220 (compound 43), which has a longer hydrophobic chain, exhibited potent antibacterial activity against both Gram-positive bacteria (MICs of 0.78-1.56 μg/mL) and Gram-negative bacteria (MIC of 6.25 μg/mL) and poor hemolytic activity (HC50 > 200 μg/mL). Antibacterial agent 220 shows MIC values of 1.56 μg/mL, 0.78 μg/mL, 0.78 μg/mL, and 6.25 μg/mL for S. aureus ATCC29213, MRSA N315, MRSA NCTC10442, and E. coli ATCC25922, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks old mice (C57BL6) bearing bacterial cells (S. aureus ATCC29213)[1]
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Dosage:0.5%
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Administration:Applied topically to the infected murine corneas; four times, with an interval of about 2 h; for three consecutive days
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Result:Exhibited a strong in vivo antibacterial efficacy.
Chemical Information
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Molecular Weight 770.94
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Formel C37H54N8O8S
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SMILES
O=S(C1=CC=C(OC/C=C(CC/C=C(C)/C)/C)C=C1)(C2=CC=C(OCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(OC)=O)CCCNC(N)=N)=O)=O)C=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antibacterial agent 220 Related Classifications
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