Antibacterial agent 220
Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C37H54N8O8S
- 分子量:770.94
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against HEK293 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
| L929 | CC50 |
>100 μg/mL
Compound: 43
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Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
Cytotoxicity against mouse NCTC clone 929 cells assessed reduction in cell viability incubated for 24 hrs by CCK-8 assay
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[PMID: 38850855] |
体外実験
Antibacterial agent 220 (compound 43), which has a longer hydrophobic chain, exhibited potent antibacterial activity against both Gram-positive bacteria (MICs of 0.78-1.56 μg/mL) and Gram-negative bacteria (MIC of 6.25 μg/mL) and poor hemolytic activity (HC50 > 200 μg/mL). Antibacterial agent 220 shows MIC values of 1.56 μg/mL, 0.78 μg/mL, 0.78 μg/mL, and 6.25 μg/mL for S. aureus ATCC29213, MRSA N315, MRSA NCTC10442, and E. coli ATCC25922, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks old mice (C57BL6) bearing bacterial cells (S. aureus ATCC29213)[1]
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Dosage:0.5%
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Administration:Applied topically to the infected murine corneas; four times, with an interval of about 2 h; for three consecutive days
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Result:Exhibited a strong in vivo antibacterial efficacy.
化学情報
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分子量 770.94
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分子式 C37H54N8O8S
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SMILES
O=S(C1=CC=C(OC/C=C(CC/C=C(C)/C)/C)C=C1)(C2=CC=C(OCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(OC)=O)CCCNC(N)=N)=O)=O)C=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antibacterial agent 220 関連分類
HY-161689 関連分類
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