Bromochloro-5,5-dimethylhydantoin  (Synonyms: BCDMH)

Bromochloro-5,5-dimethylhydantoin is a bactericidal agent and membrane-disrupting agent. Bromochloro-5,5-dimethylhydantoin disrupts bacterial cell membranes, alters membrane structure and permeability, and induces leakage of soluble proteins and ions from bacterial cells. Bromochloro-5,5-dimethylhydoin exhibits bactericidal activity against bacteria^[1].

Bromochloro-5,5-dimethylhydantoin (5-25 mg/L; 3 min) induces potent bactericidal activity against Escherichia coli 8099, resulting in 6.56 and 6.99 log₁₀ reductions in viable counts after 3 min of exposure at 20 mg/L and 25 mg/L respectively, while lower concentrations induce less or no bactericidal effect^[1].
Bromochloro-5,5-dimethylhydantoin (20 mg/L; 3 min) induces elongation of Escherichia coli 8099 cells, suggesting an SOS response, while causing less visible membrane surface damage compared to other treatments^[1].
Bromochloro-5,5-dimethylhydantoin (20 mg/L; 1, 3, 5, 10, 20 min post-exposure) induces minimal leakage of potassium and magnesium ions from Escherichia coli 8099 cells, with ion leakage remaining near baseline levels over 20 min of exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

241.47

C₅H₆BrClN₂O₂

16079-88-2

Solid

O=C1N(Cl)C(=O)C(N1Br)(C)C

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Huai W, et al. Enhanced killing of Escherichia coli using a combination of polyhexamethylene biguanide hydrochloride and 1-bromo-3-chloro-5,5- dimethylimidazolidine-2,4-dione. FEMS Microbiol Lett. 2017;364(21):10.1093/femsle/fnx210.