2. Anti-infection
  3. Bacterial
  4. Ziapin 2

Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the bacterial plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties.

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Ziapin 2

Ziapin 2 Chemical Structure

CAS No. : 2399497-60-8

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Based on 1 publication(s) in Google Scholar

Ziapin 2 Related Antibodies

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Description

Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the bacterial plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties[1][2].

In Vitro

Ziapin 2 (0-80 μg/mL) binds to the cell surface of Bacillus subtilis, penetrates its cell membrane, and undergoes light-induced isomerization after embedding into the membrane. It depolarizes the resting membrane potential of wild-type Bacillus subtilis cells under dark conditions and induces reproducible light-induced hyperpolarization in wild-type Bacillus subtilis cells[1].
Ziapin 2 (5-25 μM; 283-310 K) globally softens the bilayer membrane of POPC liposomes and restores their dynamic flexibility at 283, 300, and 310 K[2].
Ziapin 2 (25 μM; 7 min at 37 °C) restores the membrane dynamics of intact HEK293 cells inhibited by DMSO at 300 K[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziapin 2 Related Antibodies
Molecular Weight

778.70

Formula

C40H54Br2N6
CAS No.
Appearance

Solid

Color

Green to dark green

SMILES

N(CCCCCC[N+]1=CC=CC=C1)(C2=CC=C(C=C2)/N=N/C3=CC=C(N4CCCCCC4)C=C3)CCCCCC[N+]5=CC=CC=C5.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (64.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2842 mL 6.4210 mL 12.8419 mL
5 mM 0.2568 mL 1.2842 mL 2.5684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2842 mL 6.4210 mL 12.8419 mL 32.1048 mL
5 mM 0.2568 mL 1.2842 mL 2.5684 mL 6.4210 mL
10 mM 0.1284 mL 0.6421 mL 1.2842 mL 3.2105 mL
15 mM 0.0856 mL 0.4281 mL 0.8561 mL 2.1403 mL
20 mM 0.0642 mL 0.3210 mL 0.6421 mL 1.6052 mL
25 mM 0.0514 mL 0.2568 mL 0.5137 mL 1.2842 mL
30 mM 0.0428 mL 0.2140 mL 0.4281 mL 1.0702 mL
40 mM 0.0321 mL 0.1605 mL 0.3210 mL 0.8026 mL
50 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6421 mL
60 mM 0.0214 mL 0.1070 mL 0.2140 mL 0.5351 mL
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Ziapin 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziapin 22399497-60-8Ziapin2Ziapin-2BacterialMembrane potential modulatorsintramembrane photoactuatorsBacillus subtilisHEK293 cellsInhibitorinhibitorinhibit

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