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Results for "

non-covalent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Antibiotic (1) Apolipoprotein (1) Apoptosis (15) Arginase (2) AUTACs (1) Autophagy (2) Bacterial (16) Bcl-2 Family (2) Beta-lactamase (1) Biochemical Assay Reagents (31) Btk (15) ByeTAC (1) Calcium Channel (2) Caspase (2) Cathepsin (6) CDK (9) Ceramidase (1) CHIKV (2) Cholinesterase (ChE) (1) ClpP (1) Collagen (2) COX (2) CRFR (2) CRM1 (3) Cyclophilin (1) Cytochrome P450 (1) Dengue Virus (1) Deubiquitinase (4) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (3) DNA Methyltransferase (6) DNA Stain (1) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Intermediate (2) E1/E2/E3 Enzyme (1) EGFR (5) Endogenous Metabolite (4) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (4) FAAH (1) Ferroptosis (4) Flavivirus (1) FLT3 (1) Fluorescent Dye (6) Fungal (2) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (1) GHR (1) GHSR (1) Glutathione Peroxidase (1) Glycosidase (1) GnRH Receptor (1) HCV (2) HCV Protease (4) HDAC (1) Histone Demethylase (5) Histone Methyltransferase (2) HIV (3) HSP (2) IDE (1) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Itk (1) Keap1-Nrf2 (2) Lactate Dehydrogenase (1) LDLR (1) mAChR (1) Macrophage migration inhibitory factor (MIF) (1) MAGL (2) MDM-2/p53 (1) MEK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (3) Mitophagy (2) Mixed Lineage Kinase (1) MNK (1) Monoamine Oxidase (1) Na+/K+ ATPase (1) Necroptosis (1) NEDD8-activating Enzyme (4) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (1) Notch (4) Opioid Receptor (3) Orthopoxvirus (1) p38 MAPK (2) Parasite (3) PARP (2) PCSK9 (2) PERK (2) Phosphatase (4) Phosphoglycerate Dehydrogenase (PHGDH) (1) Phospholipase (4) Phytohormone (1) PI3K (3) PKA (1) PPAR (1) Prostaglandin Receptor (1) PROTACs (2) Proteasome (3) Protein Arginine Deiminase (1) Ras (11) Reactive Oxygen Species (ROS) (2) Reference Standards (7) Renin (1) RGS Protein (1) RIP kinase (2) RNA MTase (1) SARS-CoV (28) Sodium Channel (1) SOS1 (2) Src (1) STING (2) TGF-beta/Smad (2) Topoisomerase (2) TrxR (1) Virus Protease (11) Wnt (1) YAP (2)
By Research Areas:	Cancer (106) Cardiovascular Disease (13) Endocrinology (7) Infection (59) Inflammation/Immunology (22) Metabolic Disease (15) Neurological Disease (19)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pegylated Lipids (5)

248

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3152

Streptavidin 5 Publications Verification	Biochemical Assay Reagents	Others
Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a K_D ~0.01 pM . Streptavidin has an immunosuppressive role . This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

HY-114299

Salcaprozate sodium 4 Publications Verification SNAC	Biochemical Assay Reagents	Others
Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-135146

GSK-3484862 20+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-152857

Muvalaplin LY3473329	LDLR	Cardiovascular Disease
Muvalaplin (LY3473329) is an orally active, selective small molecule inhibitor of lipoprotein (a) (Lp (a)) that disrupts the initial non-covalent interaction between apo(a) and apoB100, preventing the disulphide bond and Lp(a) formation. Muvalaplin reduces the levels of Lp (a) in transgenic mice and in cynomolgus monkeys .

HY-129589

Thailanstatin A 2 Publications Verification	ADC Payload	Cancer
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC₅₀=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC₅₀s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .

HY-143216

Ensitrelvir 10+ Cited Publications S-217622	SARS-CoV Virus Protease	Infection
Ensitrelvir (S-217622) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC₅₀=13 nM) .

HY-112215

Nemtabrutinib 4 Publications Verification ARQ-531; MK-1026	Btk	Inflammation/Immunology Cancer
Nemtabrutinib (ARQ 531) is a reversible non-covalent and orally active inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC₅₀s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

HY-110275

RA839	Keap1-Nrf2 NO Synthase	Infection Inflammation/Immunology
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (K_d is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .

HY-112937

GNE-6640 5+ Cited Publications	Deubiquitinase	Cancer
GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC₅₀ values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively .

HY-W095670

2,4,7-Trichloro-8-fluoropyrido[4,3-d]pyrimidine	Drug Intermediate	Others
2,4,7-Trichloro-8-fluoropyridopyrimidine is a pyridopyrimidine synthetic intermediate of MRTX1133 (HY-134813), which can be used for the synthesis of non-covalent KRAS ^G12D inhibitors .

HY-109198

Zandelisib ME-401; PWT-143	PI3K Akt	Cancer
Zandelisib (ME-401) is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma .

HY-139535

Luxeptinib 1 Publications Verification CG-806	FLT3 Btk Apoptosis	Cancer
Luxeptinib (CG-806) is an orally active, reversible, first-in-class, non-covalent and potent pan-FLT3/pan-BTK inhibitor. Luxeptinib induces cell cycle arrest, apoptosis or autophagy in acute myeloid leukemia cells .

HY-143216A

Ensitrelvir fumarate 10+ Cited Publications S-217622 fumarate	SARS-CoV Virus Protease	Infection
Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC₅₀=13 nM) .

HY-136430

JCN037 JGK037	EGFR	Cancer
JCN037 (JGK037) is non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC₅₀ values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively .

HY-153450

JBI-589	Protein Arginine Deiminase	Cancer
JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors. JBI-589 can be used in cancer research .

HY-133130

JNJ-42226314 1 Publications Verification	MAGL	Neurological Disease
JNJ-42226314, a chemical probe, is a competitive, highly selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and inflammatory pain .

HY-136298A

X77	SARS-CoV	Infection
X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-141514

MSA-2 dimer 1 Publications Verification	STING	Inflammation/Immunology Cancer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

HY-156820

HLDA-221	Epigenetic Reader Domain	Cancer
HLDA-221 is a non-covalent regulated induced proximity targeting chimeras (RIPTAC). The binding of HLDA-221 to BRD4-BD1 is significantly increased after pre-incubation with FKBP. HLDA-221 can be used in cancer research .

HY-160167

Birelentinib DZD8586	Src Btk	Inflammation/Immunology Cancer
Birelentinib (DZD8586) is an orally effective, selective, non-covalent inhibitor targeting LYN tyrosine kinase and BTK tyrosine kinase, capable of penetrating the blood-brain barrier. Birelentinib exhibits concentration-dependent antiproliferative effects in RI-1 cells and diffuse large B-cell lymphoma (DLBCL) cell lines carrying BTK resistance mutations (such as C481X, V416L, etc.). Birelentinib blocks both BTK-dependent and independent signaling of the B-cell receptor (BCR), thereby inhibiting tumor cell proliferation and inducing cell death. Birelentinib can be used in research to overcome resistance to existing covalent and non-covalent BTK inhibitors in B-cell non-Hodgkin lymphoma (B-NHL) .

HY-117203A

CDK12-IN-E9 1 Publications Verification	CDK	Cancer
CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and a non-covalent CDK9 inhibitor, while avoiding ABC transporter-mediated efflux. CDK12-IN-E9 has weak binding ability to CDK7/CyclinH complex with an IC₅₀> 1 μM .

HY-114299S

Salcaprozate-d4 sodium SNAC-d4 sodium	Isotope-Labeled Compounds	Others
Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-135146A

(Rac)-GSK-3484862	DNA Methyltransferase	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-169422A

GSK4418959 (enantiomer) IDE275 (enantiomer)	DNA/RNA Synthesis	Cancer
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-114299R

Salcaprozate sodium (Standard) SNAC (Standard)	Biochemical Assay Reagents Reference Standards	Others
Salcaprozate (sodium) (Standard) is the analytical standard of Salcaprozate (sodium). This product is intended for research and analytical applications. Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-10243

Vaniprevir MK-7009	HCV HCV Protease	Infection
Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.

HY-19415

SB-435495	Phospholipase	Metabolic Disease
SB-435495 is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM .

HY-103462

TC-F2	FAAH	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
TC-F2 is a reversible non-covalent binding inhibitor of fatty acid amide hydrolase (FAAH) with an IC₅₀ of 28 nM. FAAH is involved in many human diseases, particularly cancer, pain and inflammation as well as neurological, metabolic and cardiovascular disorders .

HY-W000854

3-Methoxybenzeneboronic acid 3-Methoxyphenylboronic acid	Biochemical Assay Reagents	Others
3-Methoxybenzeneboronic acid (3-Methoxyphenylboronic acid) is a boronic acid derivative. 3-Methoxybenzeneboronic acid shows best suitable binding pattern at the active site by interacting non-covalently with amino acid residues of proteins. 3-Methoxybenzeneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-149535

Iscartrelvir WU-04	SARS-CoV	Infection
Iscartrelvir (WU-04) is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. Iscartrelvir has high inhibitory effect on the 3CLpro protein of 6 SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda and Omicron) and 2 coronaviruses (SARS-CoV and MERS-CoV) .

HY-175806

CS47	TrxR Reactive Oxygen Species (ROS) Ferroptosis	Cancer
CS47 is a Thioredoxin Reductase 1 (TRXR1) inhibitor and ferroptosis inducer. CS47 binds non-covalently to sites between the FAD and NADPH pockets of TRXR1. CS47 drives glutathione depletion, lipid reactive oxygen species accumulation, HMOX1-dependent iron overload, and selective cytotoxicity in lung cancer cells. CS47 can be used for the research of lung cancer .

HY-136259

ML188 5 Publications Verification	SARS-CoV Virus Protease	Infection
ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.5 μM. Antiviral activity .

HY-101790A

ZM223 hydrochloride	NEDD8-activating Enzyme	Cancer
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity .

HY-131328A

(R)-Pirtobrutinib (R)-LOXO-305	Btk	Others
(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations .

HY-126278

Z1609609733	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation .

HY-136531

XMU-MP-3	Btk Apoptosis	Cancer
XMU-MP-3 is a potent non-covalent BTK inhibitor with IC₅₀s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis .

HY-136298

(Rac)-X77	SARS-CoV	Infection
(Rac)-X77?is a racemate of X77. X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-175763

Z55660043	RGS Protein	Neurological Disease Metabolic Disease
Z55660043 is a Regulator of G protein signaling-14 (RGS14) inhibitor with an IC₅₀ of 2.3  μM. Z55660043 selectively and non-covalently inhibits RGS14 GTPase-accelerating protein (GAP) activity without measurable cytotoxicity. Z55660043 can be used for central nervous system and metabolic disorders research .

HY-W582504

Chlorotris(triphenylphosphine)copper CuCl(TPP)3	DNA Stain Bacterial Fungal	Infection Cancer
Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents .

HY-19415B

SB-435495 ditartrate	Phospholipase	Metabolic Disease
SB-435495 ditartrate is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM .

HY-174914

Biotin-PEG4-mal	Biochemical Assay Reagents	Others
Biotin-PEG4-mal is a PEG derivative composed of Biotin, 4 PEG units and Maleimide. Biotin can form a stable non-covalent bond with streptavidin.

HY-174938

Biotin-PEG3-Iodoacetamide	Biochemical Assay Reagents	Others
Biotin-PEG3-Iodoacetamide is a PEG derivative composed of Biotin, 3 PEG units, and Iodoacetamide. Biotin can form a stable non-covalent bond with streptavidin.

HY-134184

AUTAC2	AUTACs Autophagy	Inflammation/Immunology Cancer
AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .

HY-168432

KK181N1	Phytohormone	Others
KK181N1 is a potent inhibitor of karrikin (KAR) receptor KAI2. KK181N1 binds to the catalytic pockets of KAI2 in a non-covalent binding manner. KK181N1 selectively depress the KAR-induced phenotypes in Arabidopsis .

HY-150702

MAGLi 432	MAGL	Neurological Disease Inflammation/Immunology
MAGLi 432 is a non-covalent, potent, highly selective, and reversible MAGL inhibitor. MAGLi 432 binds with high affinity to the MAGL active site, with IC₅₀ values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme). MAGLi 432 can be used in the research of chronic inflammation, blood–brain barrier dysfunction, neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease .

HY-177936

NAE-IN-3	NEDD8-activating Enzyme	Cancer
NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC₅₀ = 0.8 μM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research .

HY-P11000

INF7TAT	Biochemical Assay Reagents	Others
INF7TAT is an amphipathic peptide containing the influenza HA2 sequence and the TAT peptide (HY-P0281). INF7TAT can associate with other macromolecules through non-covalent associations. INF7TAT can be used for non-toxic delivery of siRNAs .

HY-169228

WS-11	Btk	Cancer
WS-11 is a non-covalent reversible BTK inhibitor with IC₅₀s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds .

HY-101790

ZM223	NEDD8-activating Enzyme	Cancer
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active .

HY-147036

TTP-6171	Orthopoxvirus	Infection
TTP-6171 is a non-covalent inhibitor of Monkeypox virus I7L protease, and it can be used for research on poxvirus infections .

Cat. No.	Product Name

HY-LD004

DEL Covalent Library

14 million compounds

DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects.

Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding.

This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec

HY-L036

Covalent Screening Library

1,546 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 1,546 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

HY-L908

Lead-like Covalent Screening Library

1,248 compounds

MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

HY-L036P

Covalent Screening Library Plus

5,994 compounds

MCE covalent inhibitor library contains 5,994 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

HY-L925

Cysteine Protease Focused Library

9,188 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors.

This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Cat. No.	Product Name	Type

HY-D1808

Vari Fluor 488-Streptavidin

1 Publications Verification

Fluorescent Dyes

Vari Fluor 488-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=490 nm/515 nm.
Product Concentration: 0.8 mg/mL

HY-D1805

Vari Fluor 647-Streptavidin

Fluorescent Dyes

Vari Fluor 647-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=650 nm/665 nm.
Product Concentration: 0.8 mg/mL

HY-D1807

Vari Fluor 555-Streptavidin

Fluorescent Dyes

Vari Fluor 555-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=555 nm/565 nm.
Product Concentration: 0.8 mg/mL

HY-D1806

Vari Fluor 594-Streptavidin

1 Publications Verification

Fluorescent Dyes

Vari Fluor 594-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=590 nm/617 nm.
Product Concentration: 0.8 mg/mL

HY-D1809

Vari Fluor 405-Streptavidin

Fluorescent Dyes

Vari Fluor 405-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=405 nm/431 nm.
Product Concentration: 0.8 mg/mL

HY-D1804

Vari Fluor 680-Streptavidin

Fluorescent Dyes

Vari Fluor 680-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=680 nm/701 nm.
Product Concentration: 0.8 mg/mL

Cat. No.	Product Name	Type

HY-P3152

Streptavidin 5 Publications Verification	Biochemical Assay Reagents
Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a K_D ~0.01 pM . Streptavidin has an immunosuppressive role . This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

HY-W145665

Amylose

Biochemical Assay Reagents

Amylose is not a typical small-molecule ligand with a specific traditional receptor-binding target. It is a polysaccharide. In food science and biological systems, amylose can interact with proteins and free fatty acids through non-covalent forces like hydrophobic interactions and electrostatic interactions. For example, it can form a ternary complex with them, which is related to the structure and digestion of starch. It is widely studied in the fields of food science, carbohydrate metabolism, and is also relevant in research on controlling glycemic responses, as it affects starch digestion rate .

HY-W134005

Mg(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate	Biochemical Assay Reagents
Mg(Ⅱ)-EDTA disodium tetrahydrate is a reversible non-covalent activator of fructose diphosphatase (K_m=0.9 μM). Mg(Ⅱ)-EDTA disodium tetrahydrate synergistically activates fructose diphosphatase with free Mg ²⁺, promotes the hydrolysis of fructose-1,6-bisphosphate at pH≤8, and plays a role in enhancing the activity of key enzymes in gluconeogenesis .

HY-W000854

3-Methoxybenzeneboronic acid 3-Methoxyphenylboronic acid	Biochemical Assay Reagents
3-Methoxybenzeneboronic acid (3-Methoxyphenylboronic acid) is a boronic acid derivative. 3-Methoxybenzeneboronic acid shows best suitable binding pattern at the active site by interacting non-covalently with amino acid residues of proteins. 3-Methoxybenzeneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W190862

Biotin-PEG10-azide

Biotin-PEG10-N3

Biochemical Assay Reagents

Biotin-PEG10-azide (Biotin-PEG10-N3) is a PEG derivative composed of biotin, 10 PEG units, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-174914

Biotin-PEG4-mal	Biochemical Assay Reagents
Biotin-PEG4-mal is a PEG derivative composed of Biotin, 4 PEG units and Maleimide. Biotin can form a stable non-covalent bond with streptavidin.

HY-174938

Biotin-PEG3-Iodoacetamide	Biochemical Assay Reagents
Biotin-PEG3-Iodoacetamide is a PEG derivative composed of Biotin, 3 PEG units, and Iodoacetamide. Biotin can form a stable non-covalent bond with streptavidin.

HY-W1048669B

Biotin-PEG10000-DMG	Biochemical Assay Reagents
Biotin-PEG10000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W096120A

Azide-PEG1-Desthiobiotin

Biochemical Assay Reagents

Azide-PEG1-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 1 PEG unit, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W094751

1-Pyrenamin 1-Pyrenamine (purified by sublimation)	Biochemical Assay Reagents
1-Pyrenamin (1-Pyrenamine purified by sublimation) is utilized to create highly efficient and stable catalyst supports in direct methanol fuel cells through noncovalent functionalization of graphite nanosheets .

HY-174917

Biotin-PEG4-Acrylamide	Biochemical Assay Reagents
Biotin-PEG Acrylamide is a PEG derivative composed of Biotin, 4 PEG units and Acrylamide. Biotin can form a stable non-covalent bond with streptavidin.

HY-174956H

6-Arm-PEG10000-Biotin	Biochemical Assay Reagents
6-Arm-PEG10000-Biotin is a PEG derivative containing a biotin group. Biotin can form a stable non-covalent bond with streptavidin .

HY-174892B

Biotin-PEG20-NHS ester	Biochemical Assay Reagents
Biotin-PEG20-NHS ester is a PEG derivative composed of Biotin, 20 PEG units, and NHS ester. Biotin can form a stable non-covalent bond with streptavidin. NHS ester can bind to amino acids or other molecules containing amino groups .

HY-W096120B

Azide-PEG2-Desthiobiotin

Biochemical Assay Reagents

Azide-PEG2-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 2 PEG units, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W1048669A

Biotin-PEG5000-DMG	Biochemical Assay Reagents
Biotin-PEG5000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W796277

Dde Biotin-PEG4	Biochemical Assay Reagents
Dde Biotin-PEG4 is a PEG derivative composed of Biotin, 5 PEG units, and Dde protecting group. Biotin can form a stable non-covalent bond with streptavidin.

HY-W1048669I

Biotin-PEG3400-DMG	Biochemical Assay Reagents
Biotin-PEG3400-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669H

Biotin-PEG2000-DMG	Biochemical Assay Reagents
Biotin-PEG2000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669E

Biotin-PEG1000-DMG	Biochemical Assay Reagents
Biotin-PEG1000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-174915

Biotin-PEG7-OH	Biochemical Assay Reagents
Biotin-PEG7-OH is a PEG derivative composed of Biotin, 7 PEG units and a hydroxyl (-OH) group. Biotin can form a stable non-covalent bond with streptavidin.

HY-174892A

Biotin-PEG32-NHS ester	Biochemical Assay Reagents
Biotin-PEG32-NHS ester is a PEG derivative composed of Biotin, 32 PEG units, and NHS ester. Biotin can form a stable non-covalent bond with streptavidin. NHS ester can bind to amino acids or other molecules containing amino groups .

HY-174904

Dde Biotin-PEG4-COOH	Biochemical Assay Reagents
Dde Biotin-PEG4-COOH is a PEG derivative composed of Biotin, 5 PEG units, and a carboxyl group (-COOH). Biotin can form a stable non-covalent bond with streptavidin. The carboxyl group can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group.

HY-W096120C

Azide-PEG4-Desthiobiotin

Biochemical Assay Reagents

Azide-PEG4-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 4 PEG unit, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

Cat. No.	Product Name	Target	Research Area

HY-B0671

Vancomycin Maximum Cited Publications 94 Publications Verification	Bacterial Autophagy Antibiotic	Infection Cancer
Vancomycin is an antibiotic for the treatment of bacterial infections.

HY-P4153

Enlicitide chloride MK-0616 chloride	PCSK9	Cardiovascular Disease
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC₅₀ of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders .

HY-P5307

Peptide A5K INF7-A5K-TAT	Biochemical Assay Reagents	Others
Peptide A5K (INF7-A5K-TAT) is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy .

HY-P10709

CREKA peptide	Collagen	Cardiovascular Disease Cancer
CREKA peptide is a selective non-covalent binding agent targeting fibrin, type IV collagen, and fibronectin, often used as a targeting ligand to modify delivery carriers. CREKA peptide specifically recognizes fibrin, fibronectin, and type IV collagen that are excessively deposited in the tumor microenvironment or fibrotic tissue, mediating the targeted accumulation of the carrier at the lesion site and promoting drug internalization into target cells (such as cancer cells and activated hepatic stellate cells). CREKA peptide can enhance targeted delivery efficiency, increase drug concentration at the lesion site, and reduce systemic side effects .

HY-P4076

MPG peptides, Pβ	HIV DNA Alkylator/Crosslinker	Infection
MPG peptides, Pβ is an amphipathic cell-penetrating peptide. MPG peptides, Pβ consists of three components: the hydrophobic fusion sequence (GALFLGFLGAAGSTMGA) of HIV glycoprotein 41, a spacer domain (WSQP), and the nuclear localization signal (KKKRKV) of the large T antigen of Simian virus 40. MPG peptides, Pβ can form stable non-covalent complexes with nucleic acids (including DNA) through electrostatic interactions and improve their intracellular delivery. MPG peptides, Pβ can be used in studies of HIV-1-related immune responses .

HY-P2265A

SAH-SOS1A TFA	SOS1 Ras	Cancer
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

HY-P2203

SAHM1 1 Publications Verification	Notch	Inflammation/Immunology
SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice .

HY-P1368

Stressin I 1 Publications Verification Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)	CRFR	Endocrinology
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a K_i of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats .

HY-P1368A

Stressin I TFA 1 Publications Verification Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA	CRFR	Endocrinology
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, K_i is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats .

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-W012572A

D-Histidine hydrochloride hydrate	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-P2265

SAH-SOS1A	SOS1 Ras	Cancer
SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC₅₀=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .

HY-P2261

STAD 2 1 Publications Verification	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

HY-N9526

Lyciumin B	Peptides	Cardiovascular Disease
Lyciumin B is a cyclic peptide isolated from Lysium chinense .

HY-P1712A

Arthrofactin TFA	Biochemical Assay Reagents	Metabolic Disease
Arthrofactin (TFA) is an effective lipopeptide biosurfactant in Pseudomonas sp. MIS38. Arthrofactin (TFA) production is associated with multiple ATP dependent active transporter systems .

HY-P11000

INF7TAT	Biochemical Assay Reagents	Others
INF7TAT is an amphipathic peptide containing the influenza HA2 sequence and the TAT peptide (HY-P0281). INF7TAT can associate with other macromolecules through non-covalent associations. INF7TAT can be used for non-toxic delivery of siRNAs .

HY-P10964

Tezusomant	GHSR	Endocrinology
Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research on diseases caused by excessive growth hormone secretion, such as acromegaly .

HY-P5307A

Peptide A5K acetate INF7-A5K-TAT acetate	Biochemical Assay Reagents	Others
Peptide A5K (INF7-A5K-TAT) acetate is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K acetate can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K acetate enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy .

HY-P10118A

Cathepsin L-IN-3 TFA	Cathepsin	Others
Cathepsin L-IN-3 (Compound cat L inh. 7) TFA is selective a noncovalent cathepsin L inhibitor with a K_i of 4.3 nM .

HY-P10188

apoB (4372-4392)	Apolipoprotein	Cardiovascular Disease
apoB (4372-4392) is a potent lipoprotein(a) assembly inhibitor, with an IC₅₀ of 40 μM. apoB (4372-4392) can noncovalently bind to apolipoprotein(a) with high affinity .

HY-P3223A

Biphalin acetate	Opioid Receptor	Neurological Disease
Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P2266

SAH-EZH2	Histone Methyltransferase	Cancer
SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27 .

HY-P10118

Cathepsin L-IN-3	Cathepsin	Others
Cathepsin L-IN-3 (Compound cat L inh. 7) is selective a noncovalent cathepsin L inhibitor with a K_i of 4.3 nM .

HY-P2203A

SAHM1 TFA	Notch	Cancer
SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly.

HY-P10488

cycFWRPW	Wnt Peptides	Cancer
cycFWRPW is a peptide inhibitor of TLE1. TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors, and inhibits Wnt signaling .

HY-P10212

AVLX-125 UCCB01-125	iGluR	Neurological Disease
AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with K_d value of 10 nM. AVLX-125 can be used in the study of inflammatory pain .

HY-P2192

JMV-320	Peptides	Others
JMV-320 is an active compound.

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P10014

Bibapcitide	Peptides	Cardiovascular Disease
Bibapcitide, a 26 amino acid, inhibits thrombosis .

HY-P11063

AcfffGk	Peptides	Cancer
AcfffGk is a short peptide with the ability to self-assemble into helical nanofibers, forming non-covalently cross-linked hydrogels that serve as scaffolds for 3D cell culture .

HY-N17580

Lyciumin D	Renin	Cardiovascular Disease
Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension .

HY-125040

Isariin C	Endogenous Metabolite	Inflammation/Immunology
Isariin C is a flavonoid glycoside with antioxidant activity. Isariin C activates angiogenesis. Isariin C exhibits insecticidal activity in certain insects .

HY-W1126955

Enlicitide (decanoate) MK-0616 (decanoate)	PCSK9	Metabolic Disease Inflammation/Immunology
Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease .

HY-P11837

NECT-224	Biochemical Assay Reagents	Cancer
NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992149

Lutropin alfa	GnRH Receptor	Endocrinology
Lutropin alfa is a recombinant human luteinizing hormone (LH). Lutropin alfa consists of non-covalently linked α and β subunits, and its activity is similar to that of natural luteinizing hormone. Lutropin alfa is used to stimulate follicular development in infertility .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0671

Vancomycin Maximum Cited Publications 94 Publications Verification	Structural Classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Plant Cell Culture Microorganisms Antibiotics Disease Research Fields Source Classification Cancer	Bacterial Autophagy Antibiotic
Vancomycin is an antibiotic for the treatment of bacterial infections.

HY-N6006

1,3,6-Tri-O-galloyl-beta-D-glucose 1,3,6-Tri-O-galloyl-β-D-glucose	other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
1,3,6-Tri-O-galloyl-beta-D-glucose is a non-covalent inhibitor of tyrosinase (TYR), which can block the rate-limiting step of melanin synthesis and inhibit melanin deposition. 1,3,6-Tri-O-galloyl-beta-D-glucose has antioxidant and anti-inflammatory activities and can be used as a natural active ingredient to develop anti-freckle and whitening skin care products .

HY-N2909

Aurantiamide	Alkaloids Classification of Application Fields Other Alkaloids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	NF-κB RIP kinase Mixed Lineage Kinase
Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation, thereby improving AD mouse models. Aurantiamide has in vivo inhibitory efficacy in acute kidney injury models such as ischemia/reperfusion, sepsis, and hypertension models .

HY-W015954

(2R,3R)-Butane-2,3-diol	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .

HY-W145665

Amylose	Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Source Classification	Biochemical Assay Reagents Endogenous Metabolite
Amylose is not a typical small-molecule ligand with a specific traditional receptor-binding target. It is a polysaccharide. In food science and biological systems, amylose can interact with proteins and free fatty acids through non-covalent forces like hydrophobic interactions and electrostatic interactions. For example, it can form a ternary complex with them, which is related to the structure and digestion of starch. It is widely studied in the fields of food science, carbohydrate metabolism, and is also relevant in research on controlling glycemic responses, as it affects starch digestion rate .

HY-W012817

Methylhydroquinone	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Environmental Pollutants COX
Methylhydroquinone is an orally active COX inhibitor with IC₅₀s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions .

HY-W012572

D-Histidine	Microorganisms Source Classification	Mitochondrial Metabolism Bacterial
D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-W015954R

(2R,3R)-Butane-2,3-diol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .

HY-N9526

Lyciumin B	Cardiovascular Disease Alkaloids Classification of Application Fields Plants Solanaceae Lycium chinense Miller Disease Research Fields Indole Alkaloids Source Classification	Others
Lyciumin B is a cyclic peptide isolated from Lysium chinense .

HY-W012817R

Methylhydroquinone (Standard)	Natural Products Microorganisms Source Classification	COX Reference Standards
Methylhydroquinone (Standard) is the analytical standard of Methylhydroquinone. This product is intended for research and analytical applications. Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].

HY-W012572R

D-Histidine (Standard)	Microorganisms Source Classification	Reference Standards Mitochondrial Metabolism Bacterial
D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-N16733

Deacetyltanghinin	Apocynaceae Structural Classification Cardiacglycosides Cerbera odollam Gaertn. Plants Steroids Source Classification	Na+/K+ ATPase Apoptosis Caspase Prostaglandin Receptor
Deacetyltanghinin is a selective inhibitor targeting Na ⁺/K ⁺ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na ⁺/K ⁺ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity .

HY-N17580

Lyciumin D	Structural Classification Lycium barbarum L. Cyclopeptides Phenols Solanaceae Plants Source Classification	Renin
Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension .

HY-N17442

Echinoside A	Triterpenes Structural Classification Polysaccharides Animals Terpenoids Saccharides Source Classification	Topoisomerase Caspase PARP Fungal DNA/RNA Synthesis
Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species .

Cat. No.	Product Name	Chemical Structure

HY-114299S

Salcaprozate-d4 sodium

Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .

HY-W000854S

3-Methoxybenzeneboronic acid-d3

3-Methoxybenzeneboronic acid-d₃ is the deuterium labeled 3-Methoxybenzeneboronic acid (HY-W000854). 3-Methoxybenzeneboronic acid (3-Methoxyphenylboronic acid) is a boronic acid derivative. 3-Methoxybenzeneboronic acid shows best suitable binding pattern at the active site by interacting non-covalently with amino acid residues of proteins. 3-Methoxybenzeneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

Cat. No.	Product Name		Classification

HY-134813

MRTX1133 45+ Cited Publications		Alkynes
MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated K_D against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations .

Cat. No.	Product Name		Classification

HY-W1048669B

Biotin-PEG10000-DMG		Pegylated Lipids
Biotin-PEG10000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669A

Biotin-PEG5000-DMG		Pegylated Lipids
Biotin-PEG5000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669I

Biotin-PEG3400-DMG		Pegylated Lipids
Biotin-PEG3400-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669H

Biotin-PEG2000-DMG		Pegylated Lipids
Biotin-PEG2000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

HY-W1048669E

Biotin-PEG1000-DMG		Pegylated Lipids
Biotin-PEG1000-DMG is a compound composed of biotin, PEG, and myristoyl-sn-glycerol, used for drug delivery. Biotin forms a stable non-covalent bond with streptavidin.

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