OATD-02 hydrochloride
Based on 1 publication(s) in Google Scholar
OATD-02 hydrochloride is the hydrochloride salt form of OATD-02 (HY-155108). OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study.
For research use only. We do not sell to patients.
- Purity: 99.88%
- Formula: C12H26BClN2O4
- Molecular Weight:308.61
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) OATD-02 hydrochloride
More
Biological Activity
IC50: 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1)
OATD-02 hydrochloride inhibits mouse ARG in BMDM cells with IC50 values of 912.9 nM and human ARG2 in transfected CHO-K1 cells with IC50 of 171.6 nM, and inhibits hARG1 in human primary hepatocytes at a much higher micromolar concentration (IC50 = 13 μM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
OATD-02 (5 mg/kg, oral gavage) hydrochloride increases fourfold of the L-arginine concentration in plasma sustained even 1 week after end of a treatment[1].
OATD-02 (twice per day at 50 mg/kg, oral gavage) hydrochloride inhibits the tumor growth in B16F10 orthotopic xenograft tumor model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 orthotopic xenograft tumor model[1]
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Dosage:Twice per day at 50 mg/kg for 15 days
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Administration:Oral gavage
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Result:Inhibited tumor growth (TGI 46%).
Chemical Information
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Appearance Solid
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Molecular Weight 308.61
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Formula C12H26BClN2O4
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Color White to off-white
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SMILES
N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Blockade of CCR5+ T Cell Accumulation in the Tumor Microenvironment Optimizes Anti-TGF-β/PD-L1 Bispecific Antibody. [Abstract]2024 Sep 20:e2408598. PMID: 39303165
Solvent & Solubility
H2O : 250 mg/mL (810.08 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2403 mL | 16.2017 mL | 32.4034 mL | 81.0084 mL |
| 5 mM | 0.6481 mL | 3.2403 mL | 6.4807 mL | 16.2017 mL | |
| 10 mM | 0.3240 mL | 1.6202 mL | 3.2403 mL | 8.1008 mL | |
| 15 mM | 0.2160 mL | 1.0801 mL | 2.1602 mL | 5.4006 mL | |
| 20 mM | 0.1620 mL | 0.8101 mL | 1.6202 mL | 4.0504 mL | |
| 25 mM | 0.1296 mL | 0.6481 mL | 1.2961 mL | 3.2403 mL | |
| 30 mM | 0.1080 mL | 0.5401 mL | 1.0801 mL | 2.7003 mL | |
| 40 mM | 0.0810 mL | 0.4050 mL | 0.8101 mL | 2.0252 mL | |
| 50 mM | 0.0648 mL | 0.3240 mL | 0.6481 mL | 1.6202 mL | |
| 60 mM | 0.0540 mL | 0.2700 mL | 0.5401 mL | 1.3501 mL | |
| 80 mM | 0.0405 mL | 0.2025 mL | 0.4050 mL | 1.0126 mL | |
| 100 mM | 0.0324 mL | 0.1620 mL | 0.3240 mL | 0.8101 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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