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Cat. No.: HY-163913

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SARS-CoV-IN-5

SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL^pro inhibitor with IC₅₀s of 38 nM, 21.1 nM and 86 nM for 3CL^pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC₅₀ of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9.

For research use only. We do not sell to patients.

Formula: C₂₈H₃₀BrFN₆O₅
Molecular Weight:629.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

SARS-CoV-IN-5 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	CC₅₀	>200 μM Compound: 49	Cytotoxicity against African green monkey Vero E6 cells incubated for 24 hrs by CCK8 assay Cytotoxicity against African green monkey Vero E6 cells incubated for 24 hrs by CCK8 assay	[PMID: 39072488]

In Vitro

SARS-CoV-2-IN-96 exhibits moderate inhibitory effects against the 3CL^pro of MERS-CoV (IC₅₀=1.68 μM), HCoV-OC43 (IC₅₀=0.94μM), HCoV-229E (IC₅₀=2.56 μM), and Bat coronavirus HKU9 (IC₅₀=0.402 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 629.48
Formula C₂₈H₃₀BrFN₆O₅
SMILES

O=C(N1CCN(C)CC1)C2=CC(Br)=CC([N+]([O-])=O)=C2N[C@H]3[C@H](CCCC3)NC(C(C4=CC=CC(F)=C4N5)=CC5=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhidong Jiang, et al. Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL^pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. J Med Chem. 2024 Aug 8;67(15):12760-12783. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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