1. Anti-infection
  2. SARS-CoV
    Virus Protease
  3. ML188

ML188 

Cat. No.: HY-136259
Handling Instructions

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.

For research use only. We do not sell to patients.

ML188 Chemical Structure

ML188 Chemical Structure

CAS No. : 1417700-13-0

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Description

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity[1].

In Vitro

ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture[1].
Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC50 value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells[1].

Cell Viability Assay[1]

Cell Line: Vero E6 cells (mock-infected or infected with SARS-CoV)
Concentration: 3, 4, 5, 8,10, 15, 20, 30 μM
Incubation Time: 48 hour
Result: Against mock-infected and SARS-CoV infected cells.
Molecular Weight

433.54

Formula

C₂₆H₃₁N₃O₃

CAS No.

1417700-13-0

SMILES

O=C(NC(C)(C)C)[[email protected]@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ML188ML 188ML-188SARS-CoVVirus ProteaseSARS coronavirusprobenon-covalentantiviralinfectionreplicationInhibitorinhibitorinhibit

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