1. Anti-infection
  2. SARS-CoV
    Virus Protease
  3. ML188

ML188 

Cat. No.: HY-136259 Purity: 98.35%
Handling Instructions

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity.

For research use only. We do not sell to patients.

ML188 Chemical Structure

ML188 Chemical Structure

CAS No. : 1417700-13-0

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity[1].

In Vitro

ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture[1].
Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC50 value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells[1].

Cell Viability Assay[1]

Cell Line: Vero E6 cells (mock-infected or infected with SARS-CoV)
Concentration: 3, 4, 5, 8,10, 15, 20, 30 μM
Incubation Time: 48 hour
Result: Against mock-infected and SARS-CoV infected cells.
Molecular Weight

433.54

Formula

C₂₆H₃₁N₃O₃

CAS No.

1417700-13-0

SMILES

O=C(NC(C)(C)C)[[email protected]@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (576.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3066 mL 11.5330 mL 23.0659 mL
5 mM 0.4613 mL 2.3066 mL 4.6132 mL
10 mM 0.2307 mL 1.1533 mL 2.3066 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (14.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (14.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (14.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ML188ML 188ML-188SARS-CoVVirus ProteaseSARS coronavirusprobenon-covalentantiviralinfectionreplicationInhibitorinhibitorinhibit

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ML188
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HY-136259
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