1417700-13-0
1417700-13-0
Chemical Structure
ML188
- CAS No.: 1417700-13-0
- Formula:C26H31N3O3
- Molecular Weight:433.54
IUPAC Name: (R)-N-(4-(tert-butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide
InChIKey: JXGIYKRRPGCLFV-JOCHJYFZSA-N
SMILES: O=C(NC(C)(C)C)[C@@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O
Biological Activity: ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML188 | 99.87% | ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. | ||||||||||||||||||||
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References
- [1]. Jacobs J, et al. Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24;56(2):534-46. [Content Brief]
Keywords
