Mg(Ⅱ)-EDTA disodium tetrahydrate
Based on 1 Customer Validation
Mg(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid magnesium) disodium tetrahydrate is a divalent metal chelator and ferroptosis inducer. Mg (Ⅱ)-EDTA disodium tetrahydrate reduces E-cadherin expression by chelating Ca2+ on the surface of tumor cells, thereby triggering cell dissociation and inducing epithelial-mesenchymal transition (EMT). Mg (Ⅱ)-EDTA disodium tetrahydrate further chelates lysosomal iron to form EDTA-Fe, induces ferroptosis through the Fenton reaction, and synergistically enhances immune responses to inhibit tumor metastasis. Mg (Ⅱ)-EDTA (disodium tetrahydrate) can be used in tumor-related research.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 29932-54-5
- Formula: C10H20MgN2Na2O12
- Molecular Weight:430.56
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mg(Ⅱ)-EDTA disodium tetrahydrate (0-400 μg/mL; 6 s-15 min) rapidly and dose-dependently chelates Ca2+ while releasing Mg2+ in solution, and the resulting EDTA-Ca chelates Fe2+ with slower kinetics; EDTA-Fe generates hydroxyl radicals via Fenton reaction in a time- and concentration-dependent manner[1].
Mg(Ⅱ)-EDTA disodium tetrahydrate (500 μg/mL) exhibits selective cytotoxicity toward 4T1 tumor cells, reducing cell survival to 53.3% while sparing HUVECs (79.3% survival)[1].
Mg(Ⅱ)-EDTA disodium tetrahydrate (100 μM Fe2+) induces ferroptosis in 4T1 cells via iron deprivation, Fenton reaction-mediated ROS generation, and LPO, characterized by reduced GPX4 expression, increased ACSL4 expression, mitochondrial damage, and cell death; these effects are enhanced by exogenous Fe2+ and inhibited by DFO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mg(Ⅱ)-EDTA disodium tetrahydrate (orthotopic injection; on days 1, 3, 5, 7, 9 post-tumor implantation) significantly inhibits tumor growth and metastasis in a patient-derived xenograft model, reducing tumor volume to 41.0% of the control, while maintaining good biocompatibility[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29932-54-5
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Appearance Solid
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Molecular Weight 430.56
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Formula C10H20MgN2Na2O12
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Color White to off-white
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SMILES
O=C1[O-][Mg+2]([N]2(C1)CC3=O)([O-]3)([O-]C4=O)([O-]5)[N](C4)(CC2)CC5=O.O.[Na+].O.O.O.[Na+]
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Synonyms
Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (232.26 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (287 KB)
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SDS (456 KB)
- English - EN (456 KB)
- Français - FR (456 KB)
- Deutsch - DE (456 KB)
- Norwegian - NO (456 KB)
- Español - ES (456 KB)
- Swedish - SV (456 KB)
- Italian - IT (456 KB)
- Korean - KR (456 KB)
- Portuguese - PT (456 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3226 mL | 11.6128 mL | 23.2256 mL | 58.0639 mL |
| 5 mM | 0.4645 mL | 2.3226 mL | 4.6451 mL | 11.6128 mL | |
| 10 mM | 0.2323 mL | 1.1613 mL | 2.3226 mL | 5.8064 mL | |
| 15 mM | 0.1548 mL | 0.7742 mL | 1.5484 mL | 3.8709 mL | |
| 20 mM | 0.1161 mL | 0.5806 mL | 1.1613 mL | 2.9032 mL | |
| 25 mM | 0.0929 mL | 0.4645 mL | 0.9290 mL | 2.3226 mL | |
| 30 mM | 0.0774 mL | 0.3871 mL | 0.7742 mL | 1.9355 mL | |
| 40 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4516 mL | |
| 50 mM | 0.0465 mL | 0.2323 mL | 0.4645 mL | 1.1613 mL | |
| 60 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 80 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7258 mL | |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5806 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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