ZINC-1000507824
ZINC-1000507824 is a non-covalent reversible RNA cytosine-5 methyltransferase NSUN2 inhibitor. ZINC-1000507824 targets the SAM cofactor binding pocket of NSUN2 and forms stable NSUN2-ligand complexes. ZINC-1000507824 destabilizes oncogenic mRNAs encoding PI3K/AKT and MAPK/ERK pathway components, attenuates growth signals, reduces proliferative drive, and restores therapy sensitivity in cancer cells. ZINC-1000507824 can be used for the research of NSUN2-driven malignancies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C21H28N2O2
- Molecular Weight:340.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
Beschreibung
In Vitro
ZINC-1000507824 shows predicted high-affinity binding to the SAM cofactor binding pocket of AlphaFold2-predicted human NSUN2 with a docking score of -8.323 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 340.46
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Formel C21H28N2O2
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SMILES
[H][C@@]12CCCCCC[C@]1([H])[C@H]2C(NC3CN(C(C4C=CC=CC=C4)=O)C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ZINC-1000507824 Related Classifications
HY-181963 Related Classifications
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Keywords
- ZINC-1000507824
- ZINC1000507824
- ZINC 1000507824
- DNA Methyltransferase
- PI3K
- Akt
- p38 MAPK
- ERK
- DNMTs
- DNA MTases
- Phosphoinositide 3-kinase
- PKB
- Protein kinase B
- Extracellular signal regulated kinases
- oncogenic mRNAs
- NSUN2
- molecular dynamics simulations
- therapeutic resistance
- NSUN2-driven malignancies
- SAM cofactor binding pocket
- PI3K/AKT
- ADMET properties
- AlphaFold2-predicted human NSUN2
- MAPK/ERK pathway
- Inhibitor
- inhibitor
- inhibit