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Cat. No.: HY-181963

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ZINC-1000507824

ZINC-1000507824 is a non-covalent reversible RNA cytosine-5 methyltransferase NSUN2 inhibitor. ZINC-1000507824 targets the SAM cofactor binding pocket of NSUN2 and forms stable NSUN2-ligand complexes. ZINC-1000507824 destabilizes oncogenic mRNAs encoding PI3K/AKT and MAPK/ERK pathway components, attenuates growth signals, reduces proliferative drive, and restores therapy sensitivity in cancer cells. ZINC-1000507824 can be used for the research of NSUN2-driven malignancies.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₈N₂O₂
Molecular Weight:340.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC-1000507824 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

All DNA Methyltransferase Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All p38 MAPK Isoforms :

All ERK Isoforms :

In Vitro

ZINC-1000507824 shows predicted high-affinity binding to the SAM cofactor binding pocket of AlphaFold2-predicted human NSUN2 with a docking score of -8.323 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 340.46
Formula C₂₁H₂₈N₂O₂
SMILES

[H][C@@]12CCCCCC[C@]1([H])[C@H]2C(NC3CN(C(C4C=CC=CC=C4)=O)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu S, et al. AI-driven virtual screening platform identifies novel NSUN2 inhibitor candidates for targeted cancer therapy: a computational drug discovery approach. NPJ Precis Oncol. 2026;10(1):98. Published 2026 Jan 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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ZINC-1000507824

All DNA Methyltransferase Isoforms

All PI3K Isoforms

All Akt Isoforms

All p38 MAPK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZINC-1000507824 Related Classifications

HY-181963 Related Classifications