2. Epigenetics
  3. Epigenetic Reader Domain
  4. HLDA-221

HLDA-221 is a non-covalent regulated induced proximity targeting chimeras (RIPTAC). The binding of HLDA-221 to BRD4-BD1 is significantly increased after pre-incubation with FKBP. HLDA-221 can be used in cancer research.

For research use only. We do not sell to patients.

HLDA-221

HLDA-221 Chemical Structure

CAS No. : 3077339-82-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
25 mg In-stock
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Based on 1 publication(s) in Google Scholar

HLDA-221 Related Antibodies

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Description

HLDA-221 is a non-covalent regulated induced proximity targeting chimeras (RIPTAC). The binding of HLDA-221 to BRD4-BD1 is significantly increased after pre-incubation with FKBP. HLDA-221 can be used in cancer research[1].

IC50 & Target[1]

BRD4 (BD1)

 

In Vitro

The binding of HLDA-221 to BRD4-BD1 increases significantly (approximately 35-fold, range 25-50 fold) after pre-incubation with FKBP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HLDA-221 Related Antibodies
Molecular Weight

1220.86

Formula

C64H78ClN7O13S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(C(C(C=C1)=CC=C1Cl)=N[C@H]2CC(NCCOCCOCCN(C(COC3=CC=CC([C@@H](CCC4=CC(OC)=C(OC)C=C4)OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)=C3)=O)C)=O)=C(S7)N8C2=NN=C8C)=C7C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (81.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8191 mL 4.0955 mL 8.1909 mL
5 mM 0.1638 mL 0.8191 mL 1.6382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8191 mL 4.0955 mL 8.1909 mL 20.4774 mL
5 mM 0.1638 mL 0.8191 mL 1.6382 mL 4.0955 mL
10 mM 0.0819 mL 0.4095 mL 0.8191 mL 2.0477 mL
15 mM 0.0546 mL 0.2730 mL 0.5461 mL 1.3652 mL
20 mM 0.0410 mL 0.2048 mL 0.4095 mL 1.0239 mL
25 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.8191 mL
30 mM 0.0273 mL 0.1365 mL 0.2730 mL 0.6826 mL
40 mM 0.0205 mL 0.1024 mL 0.2048 mL 0.5119 mL
50 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.4095 mL
60 mM 0.0137 mL 0.0683 mL 0.1365 mL 0.3413 mL
80 mM 0.0102 mL 0.0512 mL 0.1024 mL 0.2560 mL
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HLDA-221 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLDA-2213077339-82-0HLDA221HLDA 221Epigenetic Reader DomainFKBP12 F36VFKBPBRD4 BD1BRD4-BD1BRD4Inhibitorinhibitorinhibit

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