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Cat. No.: HY-109198A

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Zandelisib hydrochloride

(Synonyms: ME-401 hydrochloride; PWT-143 hydrochloride)

Zandelisib (ME-401) hydrochloride is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib hydrochloride can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib hydrochloride can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma.

For research use only. We do not sell to patients.

CAS No.: 2839515-65-8
Formula: C₃₁H₃₈F₂N₈O.xHCl
Molecular Weight:576.68 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Zandelisib hydrochloride Chemical Structure

CAS No.: 2839515-65-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

All Akt Isoforms :

In Vitro

Zandelisib (10-1000 nM, 1-24 h) hydrochloride sustains AKT phosphorylation (Ser473/Thr308) inhibition in SU-DHL-6 cells after wash-out^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zandelisib (50-100 mg/kg, p.o., once daily) hydrochloride significantly inhibits tumor growth in mice bearing subcutaneously inoculated SU-DHL-6 tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SU-DHL-6 cells (1 × 10⁷) were subcutaneously implanted into the right flank of 8-week-old male SCID mice^[1]
Dosage:

50, 100 mg/kg
Administration:

p.o., once daily
Result:

Achieved sustained PI3Kδ inhibitory effects.
Demonstrated significant tumor growth inhibition.
Maintained effective intracellular concentration in tumor tissues.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2839515-65-8
Molecular Weight 576.68 (free base)
Formula C₃₁H₃₈F₂N₈O.xHCl
SMILES

CN1CCC(C2=CC=CC=C2CC(NC3=NC(N4C5=CC=CC=C5N=C4C(F)F)=NC(N6CCOCC6)=N3)(C)C)CC1.Cl.[x]
Synonyms

ME-401 hydrochloride; PWT-143 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kunieda K, et al. A long-lasting PI3Kδ inhibitor zandelisib forms a water-shielded hydrogen bond with p110δ and demonstrates sustained inhibitory effects. Am J Cancer Res. 2025 May 15;15(5):2097-2110. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Zandelisib hydrochloride

All PI3K Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Zandelisib hydrochloride Related Classifications

HY-109198A Related Classifications