1. Epigenetics
  2. Histone Demethylase
    Histone Methyltransferase
  3. LSD1-IN-20

LSD1-IN-20 

Cat. No.: HY-146285
Handling Instructions

LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively.

For research use only. We do not sell to patients.

LSD1-IN-20 Chemical Structure

LSD1-IN-20 Chemical Structure

CAS No. : 1239589-91-3

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Description

LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

IC50 & Target

Ki of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)[1]

Molecular Weight

478.63

Formula

C27H38N6O2

CAS No.
SMILES

COC1=CC2=C(C(NC3CCN(CC3)CC4=CC=CC=C4)=NC(NCCCN(C)C)=N2)C=C1OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LSD1-IN-20
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